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Analytical methodologies for the stereoselective determination of fluoxetine: An overview

https://doi.org/10.1002/bmc.4040
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1 of 52 checkable references need attention · checked 2026-07-24

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

8 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

References needing attention

does not resolve to a known work10.1111/j.1468-2982.1998.1805283.x
The 51 checked references that resolve
resolves10.1016/j.chroma.2016.05.022
Simultaneous enantioselective quantification of fluoxetine and norfluoxetine in human milk by direct sample injection using 2-dimensional liquid chromatography–tandem mass spectrometry
resolves10.1002/bmc.2802
Determination of fluoxetine enantiomers in pharmaceutical formulations by electrokinetic chromatography–counter current technique
resolves10.1002/elps.201000250
Evaluation of enantioselective binding of fluoxetine to human serum albumin by ultrafiltration and CE – Experimental design and quality considerations
resolves10.1016/j.chroma.2011.06.024
Trace analysis of fluoxetine and its metabolite norfluoxetine. Part I: Development of a chiral liquid chromatography–tandem mass spectrometry method for wastewater samples
resolves10.1016/j.chroma.2011.12.084
Trace analysis of fluoxetine and its metabolite norfluoxetine. Part II: Enantioselective quantification and studies of matrix effects in raw and treated wastewater by solid phase extraction and liquid chromatography–tandem mass spectrometry
resolves10.1002/bmc.3144
Liquid chromatographic enantioseparation of (<i>RS</i>)‐mexiletine and (<i>RS</i>)‐fluoxetine using chiral derivatizing reagents synthesized with (<i>S</i>)‐naproxen moiety
resolves10.1002/hup.336
Enantiomeric antidepressant drugs should be considered on individual merit
resolves10.1002/bmc.1421
High‐performance liquid chromatographic enantioseparation of (<i>R</i>,<i>S</i>)‐fluoxetine using Marfey's reagent and (<i>S</i>)‐<i>N</i>‐(4‐nitrophenoxycarbonyl) phenylalanine methoxyethyl ester as chiral derivatizing reagents along with direct thin‐layer chromatographic resolution and isolation of enantiomers using <scp>l</scp>‐tartaric acid as mobile phase additive
resolves10.1016/S0021-9673(02)01797-1
Electrophoretic enantiomer separations at high pH using the new, single-isomer octakis(2,3-dimethyl-6-O-sulfo)-γ-cyclodextrin as chiral resolving agent
resolves10.1590/S0103-50532011000700004
Enantioselective analysis of fluoxetine and norfluoxetine in plasma samples by protein precipitation and liquid chromatography with fluorescence detection
resolves10.4103/2229-516X.112233
A review of drug isomerism and its significance
resolves10.1016/j.jchromb.2010.12.020
A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS)
resolves10.1002/chir.20675
Use of toxicity assays for enantiomeric discrimination of pharmaceutical substances
resolves10.1002/(SICI)1522-2683(19991101)20:17<3432::AID-ELPS3432>3.0.CO;2-8
Enantiomeric separation of fluoxetine and norfluoxetine in plasma and serum samples with high detection sensitivity capillary electrophoresis
resolves10.1097/00004714-200106000-00013
Concentrations of the Enantiomers of Fluoxetine and Norfluoxetine After Multiple Doses of Fluoxetine in Cytochrome P4502D6 Poor and Extensive Metabolizers
resolves10.1016/0378-4347(96)00080-1
Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry
resolves10.1016/S1570-0232(02)00820-6
Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography
resolves10.1039/b111053p
Determination of fluoxetine enantiomers in rat plasma by pre-column fluorescence derivatization and column-switching high-performance liquid chromatography
resolves10.1016/j.jpba.2012.01.020
Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: A review
resolves10.1081/JLC-120023251
Chiral Separation of Fluoxetine and Its Analogs with Charged Cyclodextrins by Capillary Electrophoresis
resolves10.1111/j.1365-2125.2005.02538.x
Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast‐feeding
resolves10.1124/dmd.32.2.212
STEREOSELECTIVE PHARMACOKINETICS OF FLUOXETINE AND NORFLUOXETINE ENANTIOMERS IN PREGNANT SHEEP
resolves10.1016/j.chroma.2007.09.010
Stereoisomer analysis of wastewater-derived β-blockers, selective serotonin re-uptake inhibitors, and salbutamol by high-performance liquid chromatography–tandem mass spectrometry
resolves10.2174/138920006775541561
Fluoxetine Metabolism and Pharmacological Interactions: The Role of Cytochrome P450
resolves10.4088/PCC.v05n0202
Stereochemistry in Drug Action
resolves10.4103/0975-7406.99065
A novel chiral GC/MS method for the analysis of fluoxetine and norfluoxetine enantiomers in biological fluids
resolves10.59566/IJBS.2006.2085
Chiral Drugs. An Overview
resolves10.1073/pnas.94.5.2036
Blockage of 5HT <sub>2C</sub> serotonin receptors by fluoxetine (Prozac)
resolves10.1016/S0731-7085(98)00050-8
Determination of fluoxetine hydrochloride enantiomeric excess using high-performance liquid chromatography with chiral stationary phases
resolves10.1517/17460441.2014.907790
Fluoxetine: a case history of its discovery and preclinical development
resolves10.1002/1522-2683(200109)22:15<3203::AID-ELPS3203>3.0.CO;2-G
Rapid screening for chiral separations by short-end injection capillary electrophoresis using highly sulfated cyclodextrins as chiral selectors
resolves10.1002/chir.530050414
Use of cyclodextrins as chiral selectors for direct resolution of the enantiomers of fluoxetine and its metabolite norfluoxetine by HPLC
resolves10.1016/0021-9673(95)00113-2
Systematic approach to treatment of enantiomeric separations in capillary electrophoresis and liquid chromatography II. A study of the enantiomeric separation of fluoxetine and norfluoxetine
resolves10.1080/10826079208018825
Analysis of the Enantiomers of Fluoxetine and Norfluoxetine in Plasma and Tissue Using Chiral Derivatization and Normal-Phase Liquid Chromatography
resolves10.1002/elps.201400145
Application of cyclodextrins in chiral capillary electrophoresis
resolves10.1002/elps.200305481
Infinite enantiomeric resolution of basic compounds using highly sulfated cyclodextrin as chiral selector in capillary electrophoresis
resolves10.1021/jp907151n
Interaction of Serotonin and Fluoxetine: Toward Understanding the Importance of the Chirality of Fluoxetine (<i>S</i>form and<i>R</i>form)
resolves10.1007/128_2013_438
Differentiation of Enantiomers by Capillary Electrophoresis
resolves10.1002/rcm.580
Enantiomeric separation and quantification of fluoxetine (Prozac®) in human plasma by liquid chromatography/tandem mass spectrometry using liquid‐liquid extraction in 96‐well plate format
resolves10.1016/S0022-3565(25)38409-0
Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450.
resolves10.1002/elps.201400370
Evaluation of sulfated maltodextrin as a novel anionic chiral selector for the enantioseparation of basic chiral drugs by capillary electrophoresis
resolves10.1016/0378-4347(92)80367-Y
Simultaneous determination of fluoxetine and norfluoxetine enantiomers in biological samples by gas chromatography with electron-capture detection
resolves10.1016/S1570-0232(02)00725-0
Direct stereoselective assay of fluoxetine and norfluoxetine enantiomers in human plasma or serum by two-dimensional gas–liquid chromatography with nitrogen–phosphorus selective detection
resolves10.1016/j.jchromb.2007.02.008
Determination of fluoxetine, norfluoxetine and their enantiomers in rat plasma and brain samples by liquid chromatography with fluorescence detection
resolves10.1002/chir.22289
Characterizing the Effect of Cytochrome P450 (CYP) 2C8, CYP2C9, and CYP2D6 Genetic Polymorphisms on Stereoselective N‐demethylation of Fluoxetine
resolves10.1038/nrd1821
The Discovery of Fluoxetine Hydrochloride (Prozac)
resolves10.1002/ardp.200500261
Enantiomeric Separation of Fluoxetine Derivatives on Polysaccharide‐Based Chiral Columns
resolves10.1016/j.chroma.2012.03.006
Simultaneous determination of fluoxetine and norfluoxetine enantiomers using isotope discrimination mass spectroscopy solution method and its application in the CYP2C9-mediated stereoselective interactions
resolves10.1002/jssc.201501163
Indirect enantioseparation of fluoxetine in mouse serum by derivatization with 1<i>R</i>‐(–)‐menthyl chloroformate followed by ultra high performance liquid chromatography and quadrupole time‐of‐flight mass spectrometry
resolves10.1631/jzus.2007.B0056
Comparison of the performance of chiral stationary phase for separation of fluoxetine enantiomers
resolves10.1038/nsmb.1602
Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures
The 8 references without a DOI — listed, not checked
no DOI — not checkedN‐(3‐sulfo, 3‐carboxy)‐propionylchitosan as new chiral selector for enantioresolution of basic drugs by capillary electrophoresis
no DOI — not checkedEnantioselective analysis of fluoxetine in pharmaceutical formulations by capillary zone electrophoresis
no DOI — not checkedThe search for new off‐label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs
no DOI — not checkedFluoxetine mechanism of action
no DOI — not checkedComparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo
no DOI — not checkedFluoxetine: An update of its use in major depressive disorder in adults
no DOI — not checkedImprovement of capillary electrophoretic enantioeseparation of fluoxetine by a cationic additive
no DOI — not checkedFluoxetine versus other types of pharmacotherapy for depression
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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