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The protective effect of kaempferol on heart via the regulation of Nrf2, NF‐κβ, and PI3K/Akt/GSK‐3β signaling pathways in isoproterenol‐induced heart failure in diabetic rats

https://doi.org/10.1002/ddr.21495
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1 of 60 checkable references need attention · checked 2026-07-23

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

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References needing attention

marked retracted — notice via Crossref, record curated by Retraction Watch10.1155/2015/532984
Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic<b><i>β</i></b>-Cell Mass in Middle-Aged Obese Diabetic Mice
The 59 checked references that resolve
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Marantodes pumilum (Kacip fatimah) enhances in-vitro glucose uptake in 3T3-L1 adipocyte cells and reduces pancreatic complications in streptozotocin-nicotinamide induced male diabetic rats
resolves10.1016/j.jnutbio.2018.04.014
Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice
resolves10.3390/molecules23092338
The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production
resolves10.1179/1351000214Y.0000000117
Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats
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Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats
resolves10.3389/fphar.2015.00102
The case for inhibiting p38 mitogen-activated protein kinase in heart failure
resolves10.1080/07853890510007232
Inflammatory and anti‐inflammatory cytokines in chronic heart failure: Potential therapeutic implications
resolves10.1242/jcs.031682
Control of mitochondrial apoptosis by the Bcl-2 family
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A Review on the Dietary Flavonoid Kaempferol
resolves10.1016/S0076-6879(55)02300-8
[136] Assay of catalases and peroxidases
resolves10.1007/s12020-018-1525-4
Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress
resolves10.1016/j.intimp.2018.01.002
Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway
resolves10.1155/2017/4826724
The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus
resolves10.1016/j.phrs.2015.05.002
Kaempferol and inflammation: From chemistry to medicine
resolves10.1016/j.abb.2010.03.019
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
resolves10.1016/S0076-6879(84)05015-1
[12] Assays of glutathione peroxidase
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Do the SGLT-2 Inhibitors Offer More than Hypoglycemic Activity?
resolves10.1161/CIRCRESAHA.117.311401
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
resolves10.1161/CIRCRESAHA.110.223545
Oxidative Stress and Diabetic Complications
resolves10.7150/ijms.9056
<i>Chlorophytum borivilianum</i> Root Extract Maintains near Normal Blood Glucose, Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats
resolves10.1016/j.ijcard.2016.07.250
Methanolic seed extract of Vitis vinifera ameliorates oxidative stress, inflammation and ATPase dysfunction in infarcted and non-infarcted heart of streptozotocin–nicotinamide induced male diabetic rats
resolves10.1016/S0021-9258(19)42083-8
Glutathione S-Transferases
resolves10.1152/ajpheart.01211.2011
Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/d<i>t</i><sub>max</sub> complementary or redundant?
resolves10.1161/CIRCHEARTFAILURE.114.001297
Cardiomyocyte p65 Nuclear Factor-κB Is Necessary for Compensatory Adaptation to Pressure Overload
resolves10.1152/ajpendo.00623.2009
Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
resolves10.1002/jcb.27058
Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats
resolves10.1155/2015/624159
Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by<i>Withania somnifera</i>Leaf Extract
resolves10.1038/s41419-018-0930-1
Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells
resolves10.4103/1673-5374.238714
Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia
resolves10.1182/blood-2007-09-115170
Targeting NF-κB in Waldenstrom macroglobulinemia
resolves10.1016/S0140-6736(11)60471-6
Glycaemic control and incidence of heart failure in 20 985 patients with type 1 diabetes: an observational study
resolves10.12816/0003082
The Role of Oxidative Stress and Antioxidants in Diabetic Complications = دور الإجهاد التأكسدي و المواد المضادة للأكسدة في مضاعفات مرض السكري
resolves10.1186/s12933-017-0645-0
Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models
resolves10.1007/s10741-012-9313-3
Diabetic cardiomyopathy: pathophysiology and clinical features
resolves10.1016/S0021-9258(19)45228-9
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
resolves10.1167/iovs.10-5775
Transcriptional Regulation of Activating Transcription Factor 4 under Oxidative Stress in Retinal Pigment Epithelial ARPE-19/HPV-16 Cells
resolves10.1101/cshperspect.a000034
The NF- B Family of Transcription Factors and Its Regulation
resolves10.1016/0003-2697(79)90738-3
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
resolves10.1016/S0140-6736(18)31506-X
Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study
resolves10.1126/science.179.4073.588
Selenium: Biochemical Role as a Component of Glutathione Peroxidase
resolves10.1097/ICO.0000000000000421
Mutations in the Corneal Endothelial Dystrophy–Associated Gene SLC4A11 Render the Cells More Vulnerable to Oxidative Insults
resolves10.1186/s12889-018-5653-9
Cardiovascular disease (CVD) and associated risk factors among older adults in six low-and middle-income countries: results from SAGE Wave 1
resolves10.1161/CIRCULATIONAHA.115.012427
Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia/Reperfusion
resolves10.1155/2016/7580731
Kaempferol Attenuates Myocardial Ischemic Injury <i>via</i> Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia‐Reperfusion Injury
resolves10.3390/ijms18051001
Molecular Pathways Involved in the Amelioration of Myocardial Injury in Diabetic Rats by Kaempferol
resolves10.1186/1475-2840-10-4
Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy
resolves10.1016/j.biopha.2018.03.140
Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
resolves10.1007/s12012-018-9443-5
Effect of Kaempferol Pretreatment on Myocardial Injury in Rats
resolves10.2337/db08-1697
Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling
resolves10.1371/journal.pone.0197563
Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol
resolves10.1128/JVI.01697-12
Activation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway during Porcine Circovirus Type 2 Infection Facilitates Cell Survival and Viral Replication
resolves10.1016/j.jsbmb.2017.02.007
1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the β-catenin/TCF4/GSK-3β/mTOR pathway
resolves10.1016/j.tox.2011.11.018
Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro
resolves10.1371/journal.pone.0055839
Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-κB and STAT3 in Transient Focal Stroke
resolves10.1016/j.healun.2018.01.301
Advanced Heart Failure Patients With Left Ventricular Assist Devices and Heart Transplantation Have Altered Oral Microbial Diversity Alongside Endotoxemia, Inflammation and Oxidative Stress
resolves10.1039/C4FO00844H
The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice
resolves10.1167/iovs.12-9729
SERPINA3K Protects against Oxidative Stress via Modulating ROS Generation/Degradation and KEAP1-NRF2 Pathway in the Corneal Epithelium
resolves10.1155/2015/481405
Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="italic">β</mml:mi></mml:mrow></mml:math>
resolves10.1016/j.lfs.2015.05.015
Potential drugs which activate nuclear factor E2-related factor 2 signaling to prevent diabetic cardiovascular complications: A focus on fumaric acid esters
The 6 references without a DOI — listed, not checked
no DOI — not checkedKaempferol is an anti‐inflammatory compound with activity towards NF‐kappaB pathway proteins
no DOI — not checkedAdvanced glycation end products, oxidation products, and incident cardiovascular events in patients with type 2
no DOI — not checkedCardioprotective effects of ulinastatin against isoproterenol‐induced chronic heart failure through the PI3K‐Akt, p38 MAPK and NF‐κB pathways
no DOI — not checkedWine, alcohol and atherosclerosis: Clinical evidences and mechanisms. Brazilian journal of medical and biological research =
no DOI — not checkedC repurposing the diabetes drug metformin for treatment of adverse left ventricular remodelling in cardiovascular disease. Heart
no DOI — not checkedAnti‐inflammatory effects of kaempferol on helicobacter pylori‐induced inflammation
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