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Induction of hepatotoxicity by sanguinarine is associated with oxidation of protein thiols and disturbance of mitochondrial respiration

https://doi.org/10.1002/jat.1360
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44/44 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

7 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 44 checked references that resolve
resolves10.1016/j.toxlet.2003.09.007
Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids
resolves10.1262/jrd.18126
The Plant Alkaloid Sanguinarine is a Potential Inhibitor of Follicular Angiogenesis
resolves10.1016/j.taap.2006.10.025
Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization
resolves10.1074/jbc.272.48.30129
Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation
resolves10.1007/BF02005884
Sanguinarine: its potential, as a liver toxic alkaloid present in the seeds ofArgemone mexicana
resolves10.3109/10408449709089896
Clinicoepidemiological, Toxicological, and Safety Evaluation Studies on Argemone Oil
resolves10.2174/138920007779815959
Metabolism of Sanguinarine: The Facts and The Myths
resolves10.1016/j.toxlet.2006.05.002
Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital
resolves10.1016/j.bbagen.2007.05.005
Specific binding and self-structure induction to poly(A) by the cytotoxic plant alkaloid sanguinarine
resolves10.1016/0014-5793(91)80347-6
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
resolves10.1038/sj.bjp.0703279
Induction of skeletal muscle contracture and calcium release from isolated sarcoplasmic reticulum vesicles by sanguinarine
resolves10.1254/jjp.85.47
Mechanisms Underlying the Induction of Vasorelaxation in Rat Thoracic Aorta by Sanguinarine
resolves10.1161/01.CIR.0000135475.35758.23
Heme Oxygenase-1 Inhibits Angiotensin II-Induced Cardiac Hypertrophy In Vitro and In Vivo
resolves10.1007/s11373-005-3007-y
Induction of contracture and extracellular Ca2+ influx in cardiac muscle by sanguinarine: a study on cardiotoxicity of sanguinarine
resolves10.1158/0008-5472.CAN-05-4033
Cyclooxygenase 2 Rescues LNCaP Prostate Cancer Cells from Sanguinarine-Induced Apoptosis by a Mechanism Involving Inhibition of Nitric Oxide Synthase Activity
resolves10.1158/0008-5472.CAN-06-3764
Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells
resolves10.1016/j.atherosclerosis.2006.05.023
Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production
resolves10.1007/BF02623304
Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations
resolves10.1055/s-2007-971493
Antiinflammatory Activity of Quaternary Benzophenanthridine Alkaloids from<i>Chelidonoum majus</i>*,**
resolves10.1111/j.1742-4658.2006.05227.x
The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding
resolves10.1016/S0021-9258(19)52451-6
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
resolves10.1055/s-2006-959570
Quercetin-Induced Benzophenanthridine Alkaloid Production in Suspension Cell Cultures of<i>Sanguinaria canadensis</i>
resolves10.1016/j.cbi.2007.12.006
Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines
resolves10.1016/S0167-7799(97)01068-8
Selective targeting of bioactive compounds to mitochondria
resolves10.1111/j.1432-1033.1968.tb00428.x
Formation of Malonaldehyde from Phospholipid Arachidonate during Microsomal Lipid Peroxidation
resolves10.1016/j.tiv.2007.08.023
Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects
resolves10.1016/j.jchromb.2005.10.030
A liquid chromatographic–mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat
resolves10.1016/S0006-3495(99)77214-0
Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives
resolves10.1016/S0031-9422(96)00545-6
Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores
resolves10.1016/0003-2697(68)90092-4
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
resolves10.1016/0014-2999(79)90245-0
Sanguinarine: A positive inotropic alkaloid which inhibits cardiac Na+,K+-ATPase
resolves10.1093/ajcn/28.8.883
Epidemic dropsy in New Delhi
resolves10.1055/s-2007-969901
Inhibition of Acetylcholinesterase Activity by some Isoquinoline Alkaloids*,**
resolves10.1055/s-2007-969916
Inhibition of Butyrylcholinesterase Activity by Some Isoquinoline Alkaloids
resolves10.1016/S0378-4274(01)00430-1
Cytotoxicity of natural compounds in hepatocyte cell culture models
resolves10.1002/jat.2550110309
Biochemical toxicology of argemone oil. I. effect on hepatic cytochrome P‐450 and xenobiotic metabolizing enzymes
resolves10.1016/0300-483X(89)90142-X
Biochemical toxicology of argemone oil. IV short-term oral feeding response in rats
resolves10.1055/s-2006-957924
Benzophenanthridine Alkaloids of<i>Chelidonium majus</i>; I. Inhibition of 5- and 12-Lipoxygenase by a Non-Redox Mechanism
resolves10.1080/00498250701230542
Disposition of sanguinarine in the rat
resolves10.1016/S1570-0232(03)00308-8
Electrophoretic investigation of interactions of sanguinarine and chelerythrine with molecules containing mercapto group
resolves10.1074/jbc.M501467200
The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1
resolves10.1007/s10565-007-9014-1
Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine
resolves10.1016/j.toxlet.2004.03.005
Involvement of cytochrome P450 1A in sanguinarine detoxication
resolves10.1055/s-2006-957749
Inhibition of Eukaryote Protein Kinases by Isoquinoline and Oxazine Alkaloids
The 7 references without a DOI — listed, not checked
no DOI — not checkedActivation of prodeath Bcl‐2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes
no DOI — not checkedDifferential antiproliferative and apoptotic response sanguinarine for cancer cells versus normal cells
no DOI — not checkedA disorder in the energy‐conversion processes in the liver mitochondria of rats under the action of sanguinarine and AFMA
no DOI — not checkedSanguinarine and ellipticine cytotoxic alkaloids isolated from well‐known antitumor plants. Intracellular targets of their action
no DOI — not checkedSafety of sanguinaria extract as used in commercial toothpaste and oral rinse products
no DOI — not checkedMethods in Enzymology
no DOI — not checkedAntimicrobial agents from higher plants. An investigation of Hunnemannia fumariaefolia pseudoalcoholates of sanguinarine and chelerythrine
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