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Pharmacokinetic Properties and Human Use Characteristics of an FDA‐Approved Intranasal Naloxone Product for the Treatment of Opioid Overdose

https://doi.org/10.1002/jcph.759
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28/28 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

9 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 28 checked references that resolve
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Trends in Opioid Analgesic Abuse and Mortality in the United States
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Increases in Drug and Opioid Overdose Deaths — United States, 2000–2014
resolves10.1056/NEJMra1508490
Relationship between Nonmedical Prescription-Opioid Use and Heroin Use
resolves10.7326/0003-4819-158-1-201301010-00013
Expanded Access to Opioid Overdose Intervention: Research, Practice, and Policy Needs
resolves10.1056/NEJMra1202561
Management of Opioid Analgesic Overdose
resolves10.1007/s13346-012-0092-0
A response to the opioid overdose epidemic: naloxone nasal spray
resolves10.2105/AJPH.2008.146647
Saved by the Nose: Bystander-Administered Intranasal Naloxone Hydrochloride for Opioid Overdose
resolves10.1186/1471-2458-14-297
Overdose rescues by trained and untrained participants and change in opioid use among substance-using participants in overdose education and naloxone distribution programs: a retrospective cohort study
resolves10.1016/j.jsat.2012.07.004
Opioid overdose prevention with intranasal naloxone among people who take methadone
resolves10.1001/jamainternmed.2013.12711
High-Risk Use by Patients Prescribed Opioids for Pain and Its Role in Overdose Deaths
resolves10.5694/j.1326-5377.2005.tb06550.x
Randomised trial of intranasal versus intramuscular naloxone in prehospital treatment for suspected opioid overdose
resolves10.1111/j.1360-0443.2009.02724.x
Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose
resolves10.1007/s40122-015-0035-9
Comparative Usability Study of a Novel Auto-Injector and an Intranasal System for Naloxone Delivery
resolves10.1023/A:1026451721686
Confidence Interval Criteria for Assessment of Dose Proportionality
resolves10.1542/peds.2006-1139
Development and Validation of the Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen): A Tool to Screen Adolescents for Below-Grade Reading in Health Care Settings
resolves10.1097/FTD.0b013e3181816214
Population Pharmacokinetics of Intravenous, Intramuscular, and Intranasal Naloxone in Human Volunteers
resolves10.1016/j.pharmthera.2012.03.003
Intranasal drug delivery: An efficient and non-invasive route for systemic administration
resolves10.1111/add.13209
Clinical provision of improvised nasal naloxone without experimental testing and without regulatory approval: imaginative shortcut or dangerous bypass of essential safety procedures?
resolves10.3109/10903127.2014.896961
Pitfalls of Intranasal Naloxone
resolves10.3109/10903127.2014.942485
Pitfalls of Intranasal Narcan – Response to a Letter to the Editor
resolves10.1586/17512433.2014.922866
Sex and gender influences on pharmacological response: an overview
resolves10.1146/annurev.pharmtox.44.101802.121453
Sex Differences in Pharmacokinetics and Pharmacodynamics
resolves10.1007/BF02246017
Sex differences in plasma cocaine levels and subjective effects after acute cocaine administration in human volunteers
resolves10.1016/S0893-133X(99)00020-2
Cocaine Pharmacokinetics in Men and in Women During the Follicular and Luteal Phases of the Menstrual Cycle
resolves10.1128/AAC.01242-10
Miconazole Oral Gel Increases Exposure to Oral Oxycodone by Inhibition of CYP2D6 and CYP3A4
resolves10.1213/01.ANE.0000132927.47528.8B
A Multiple-Dose Phase I Study of Intranasal Hydromorphone Hydrochloride in Healthy Volunteers
resolves10.1067/mcp.2002.128386
Disposition of nasal, intravenous, and oral methadone in healthy volunteers
resolves10.1016/j.drugalcdep.2014.12.009
Brief overdose education is sufficient for naloxone distribution to opioid users
The 9 references without a DOI — listed, not checked
no DOI — not checkedOpioid overdose prevention programs providing naloxone to laypersons—United States, 2014
no DOI — not checkedSubstance Abuse and Mental Health Services Administration.Drug Abuse Warning Network 2011: National Estimates of Drug‐Related Emergency Department Visits. HHS Publication No. (SMA) 13‐4760 DAWN Series D‐39.Rockville MD:Substance Abuse and Mental Health Services Administration;2013.
no DOI — not checkedInternational Conference on Harmonisation (ICH).Consolidated Good Clinical Practice: Guidelines (E6).1996.http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E6/E6_R1_Guideline.pdf.
no DOI — not checkedUS Food and Drug Administration Center for Devices and Radiological Health Office of Device Evaluation.Draft Guidance for Industry and Food and Drug Administration Staff: Applying Human Factors and Usability Engineering to Optimize Medical Device Design.2011.http://www.fda.gov/downloads/MedicalDevices/.../UCM259760.pdf.
no DOI — not checkedFood and Drug Administration, Center for Drug Evaluation and Research (CDER)
no DOI — not checkedRapid estimate of adult literacy in medicine: a shortened screening instrument
no DOI — not checkedNarcan (Naloxone Hydrochloride Injection USP).http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/016636s052s054lbl.pdf.
no DOI — not checkedHighlights of prescribing information for Evzio.http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205787Orig1s000lbl.pdf.
no DOI — not checkedHeroin epidemic is yielding to a deadlier cousin: fentanyl.http://www.nytimes.com/2016/03/26/us/heroin‐fentanyl.html?emc=eta1&. Accessed March 25 2016.
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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