Reference health

Mechanism of neurotransmitter release coming into focus

241/241 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

The 241 checked references that resolve

resolves10.1016/j.neuron.2013.10.022

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

resolves10.1101/cshperspect.a005702

Short-Term Presynaptic Plasticity

resolves10.1126/science.1161748

Membrane Fusion: Grappling with SNARE and SM Proteins

resolves10.1146/annurev-biophys-060414-034057

The Synaptic Vesicle Release Machinery

resolves10.1074/jbc.273.26.15879

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

resolves10.1038/nature11320

Molecular machines governing exocytosis of synaptic vesicles

resolves10.1002/anie.201406359

The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

resolves10.3109/10409238.2015.1023252

Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins

resolves10.1111/jnc.13865

C2‐domain containing calcium sensors in neuroendocrine secretion

resolves10.1016/0092-8674(93)90376-2

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

resolves10.1038/1799

The synaptic SNARE complex is a parallel four-stranded helical bundle

resolves10.1038/26412

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

resolves10.1016/S0092-8674(00)80512-7

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

resolves10.1038/362318a0

SNAP receptors implicated in vesicle targeting and fusion

resolves10.1073/pnas.95.26.15781

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

resolves10.1038/sj.emboj.7601003

Sequential N‐ to C‐terminal SNARE complex assembly drives priming and fusion of secretory vesicles

resolves10.1371/journal.pbio.0050198

Open Syntaxin Docks Synaptic Vesicles

resolves10.1016/j.neuron.2014.10.009

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

resolves10.1016/S0092-8674(00)81742-0

Three-Dimensional Structure of an Evolutionarily Conserved N-Terminal Domain of Syntaxin 1A

resolves10.1523/JNEUROSCI.3655-07.2007

Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus

resolves10.1093/emboj/18.16.4372

A conformational switch in syntaxin during exocytosis: role of munc18

resolves10.1146/annurev-cellbio-101011-155818

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

resolves10.1038/86174

resolves10.1091/mbc.E16-07-0517

A cascade of multiple proteins and lipids catalyzes membrane fusion

resolves10.1073/pnas.0812356106

Effects of linker sequences on vesicle fusion mediated by lipid-anchored DNA oligonucleotides

resolves10.7554/eLife.03251

A distinct tethering step is vital for vacuole membrane fusion

resolves10.1111/j.1600-0854.2006.00531.x

The Phagosome: Compartment with a License to Kill

resolves10.1073/pnas.96.22.12571

Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs

resolves10.1038/nsmb.1748

One SNARE complex is sufficient for membrane fusion

resolves10.1073/pnas.1107900108

In vitro system capable of differentiating fast Ca 2+ -triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

resolves10.1042/BJ20131668

Multiple conformations of a single SNAREpin between two nanodisc membranes reveal diverse pre-fusion states

resolves10.1126/science.1221976

Membrane Fusion Intermediates via Directional and Full Assembly of the SNARE Complex

resolves10.1038/nsmb.1455

Mechanics of membrane fusion

resolves10.1126/science.1193134

Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes

resolves10.1073/pnas.1101818108

Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses

resolves10.1126/science.1224492

Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

resolves10.1038/ncomms2692

Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism

resolves10.1016/S0959-4388(97)80057-8

Neurotransmitter release — four years of SNARE complexes

resolves10.1038/nature08156

Helical extension of the neuronal SNARE complex into the membrane

resolves10.1021/bi026266v

Membrane Topologies of Neuronal SNARE Folding Intermediates

resolves10.1523/JNEUROSCI.5272-05.2006

Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion

resolves10.1073/pnas.1113888108

A lipid-anchored SNARE supports membrane fusion

resolves10.1016/j.neuron.2013.09.010

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release

resolves10.1126/science.1228654

Staging Membrane Fusion

resolves10.1016/j.tcb.2006.04.006

Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release

resolves10.1016/j.ceb.2010.04.006

At the junction of SNARE and SM protein function

resolves10.1038/nature24469

A tethering complex drives the terminal stage of SNARE-dependent membrane fusion

resolves10.7554/eLife.22567

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

resolves10.1016/S0092-8674(00)81084-3

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

resolves10.1074/jbc.271.34.20223

N-Ethylmaleimide-sensitive Factor Acts at a Prefusion ATP-dependent Step in Ca2+-activated Exocytosis

resolves10.1038/11097

Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein

resolves10.1074/jbc.270.49.29182

Each Domain of the N-Ethylmaleimide-sensitive Fusion Protein Contributes to Its Transport Activity

resolves10.1038/1843

Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP

resolves10.1083/jcb.126.4.945

N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion.

resolves10.1016/S1097-2765(00)80190-2

Crystal Structure of the Vesicular Transport Protein Sec17

resolves10.1038/nature14148

Mechanistic insights into the recycling machine of the SNARE complex

resolves10.1074/jbc.M109.045286

A Conserved Membrane Attachment Site in α-SNAP Facilitates N-Ethylmaleimide-sensitive Factor (NSF)-driven SNARE Complex Disassembly

resolves10.1038/emboj.2010.97

HOPS prevents the disassembly of trans‐SNARE complexes by Sec17p/Sec18p during membrane fusion

resolves10.1038/emboj.2008.139

Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones

resolves10.1093/emboj/17.12.3269

Vam7p, a vacuolar SNAP‐25 homolog, is required for SNARE complex integrity and vacuole docking and fusion

resolves10.1083/jcb.200811082

Capture and release of partially zipped trans-SNARE complexes on intact organelles

resolves10.1073/pnas.1506409112

Sec17 can trigger fusion of trans -SNARE paired membranes without Sec18

resolves10.7554/eLife.26646

Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes

resolves10.7554/eLife.27396

Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

resolves10.1002/j.1460-2075.1995.tb07226.x

Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.

resolves10.1083/jcb.149.5.1063

Snarepins Are Functionally Resistant to Disruption by Nsf and αSNAP

resolves10.1126/science.1230473

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

resolves10.1074/jbc.RA118.003313

Arrest of trans-SNARE zippering uncovers loosely and tightly docked intermediates in membrane fusion

resolves10.1074/jbc.M114.556803

α-SNAP Interferes with the Zippering of the SNARE Protein Membrane Fusion Machinery

resolves10.1016/j.celrep.2016.03.050

α-SNAP Enhances SNARE Zippering by Stabilizing the SNARE Four-Helix Bundle

resolves10.1038/35006120

Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

resolves10.1038/nsmb1001

A minimal domain responsible for Munc13 activity

resolves10.1016/j.jmb.2009.06.054

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

resolves10.1038/nsmb.3038

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

resolves10.1126/science.287.5454.864

Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion

resolves10.1073/pnas.122623799

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

resolves10.1038/14755

UNC-13 is required for synaptic vesicle fusion in C. elegans

resolves10.1038/14764

Drosophila Unc-13 is essential for synaptic transmission

resolves10.1038/emboj.2008.37

Munc18a controls SNARE assembly through its interaction with the syntaxin N‐peptide

resolves10.1007/s10858-008-9239-1

NMR analysis of the closed conformation of syntaxin-1

resolves10.1038/nsmb.2047

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

resolves10.1126/science.1163174

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

resolves10.1074/jbc.272.4.2520

Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin

resolves10.1038/35085583

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming

resolves10.1073/pnas.0611318104

Munc18-1 binds directly to the neuronal SNARE complex

resolves10.1016/j.cell.2006.12.016

Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins

resolves10.1083/jcb.200812026

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

resolves10.7554/eLife.09580

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

resolves10.1021/bi9021878

Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle

resolves10.1073/pnas.1012997108

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE–Sec1/Munc18 membrane fusion complex

resolves10.1038/emboj.2012.307

Syntaxin‐1 N‐peptide and Habc‐domain perform distinct essential functions in synaptic vesicle fusion

resolves10.1091/mbc.E09-08-0712

Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells

resolves10.1038/emboj.2012.72

Munc18‐1 mutations that strongly impair SNARE‐complex binding support normal synaptic transmission

resolves10.1038/85012

resolves10.7554/eLife.13696

Functional synergy between the Munc13 C-terminal C1 and C2 domains

resolves10.1126/science.aac7906

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

resolves10.1074/jbc.M113.514273

An Extended Helical Conformation in Domain 3a of Munc18-1 Provides a Template for SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Complex Assembly

resolves10.1073/pnas.0914906108

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

resolves10.7554/eLife.24278

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

resolves10.1016/j.neuron.2017.07.004

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18

resolves10.1016/j.str.2016.01.005

Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex

resolves10.15252/embj.201696270

An activated Q‐SNARE/SM protein complex as a possible intermediate in SNARE assembly

resolves10.15252/embj.201695775

Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis

resolves10.1021/bi702345m

Binding of the Munc13-1 MUN Domain to Membrane-Anchored SNARE Complexes

resolves10.1016/j.str.2007.12.010

Accessory Proteins Stabilize the Acceptor Complex for Synaptobrevin, the 1:1 Syntaxin/SNAP-25 Complex

resolves10.1038/ncomms15915

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

resolves10.1523/JNEUROSCI.0338-17.2017

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans

resolves10.1016/S0092-8674(01)00635-3

β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs

resolves10.1523/JNEUROSCI.4908-06.2007

Munc13-1 C1 Domain Activation Lowers the Energy Barrier for Synaptic Vesicle Fusion

resolves10.1021/bi0476127

Intramolecular Occlusion of the Diacylglycerol-Binding Site in the C1 Domain of Munc13-1,

resolves10.1038/nsmb.1758

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

resolves10.1016/j.neuron.2017.07.015

A C1-C2 Module in Munc13 Inhibits Calcium-Dependent Neurotransmitter Release

resolves10.1038/ncomms15293

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming

resolves10.1038/emboj.2009.373

Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short‐term synaptic plasticity

resolves10.1016/j.cell.2004.06.029

Calmodulin and Munc13 Form a Ca2+ Sensor/Effector Complex that Controls Short-Term Synaptic Plasticity

resolves10.1371/journal.pbio.0040192

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

resolves10.1016/j.neuron.2011.01.005

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

resolves10.1016/S0896-6273(01)00272-0

Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming

resolves10.1038/sj.emboj.7600753

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

resolves10.1038/415321a

RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone

resolves10.1038/nn732

A post-docking role for active zone protein Rim

resolves10.1016/j.cell.2010.12.029

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

resolves10.1038/415327a

RIM1α is required for presynaptic long-term potentiation

resolves10.1038/41580

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

resolves10.1523/JNEUROSCI.3553-05.2006

Rab3 Superprimes Synaptic Vesicles for Release: Implications for Short-Term Synaptic Plasticity

resolves10.1073/pnas.0601617103

Rabs and their effectors: Achieving specificity in membrane traffic

resolves10.1038/41574

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

resolves10.1523/JNEUROSCI.2276-11.2011

Munc13-1 Is Required for Presynaptic Long-Term Potentiation

resolves10.1016/0092-8674(95)90239-2

Complexins: Cytosolic proteins that regulate SNAP receptor function

resolves10.1016/S0092-8674(01)00192-1

Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release

resolves10.1073/pnas.0803012105

Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system

resolves10.1126/science.1166505

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

resolves10.1007/s00018-015-1998-8

Complexins: small but capable

resolves10.1038/nrn.2015.16

Should I stop or should I go? The role of complexin in neurotransmitter release

resolves10.1073/pnas.1321367110

Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes

resolves10.1038/nsmb.1791

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity

resolves10.1016/j.neuron.2010.11.001

Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix

resolves10.1016/j.cell.2006.08.030

A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis

resolves10.1126/science.1129450

A Clamping Mechanism Involved in SNARE-Dependent Exocytosis

resolves10.1038/nsmb1124

Hemifusion arrest by complexin is relieved by Ca2+–synaptotagmin I

resolves10.1038/nn1980

A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

resolves10.1016/j.cub.2010.12.014

Complexin Has Opposite Effects on Two Modes of Synaptic Vesicle Fusion

resolves10.1016/j.cub.2010.12.015

Complexin Maintains Vesicles in the Primed State in C. elegans

resolves10.1074/jbc.M002571200

Selective Interaction of Complexin with the Neuronal SNARE Complex

resolves10.1016/S0896-6273(02)00583-4

Three-Dimensional Structure of the Complexin/SNARE Complex

resolves10.1038/nsmb1292

Distinct domains of complexin I differentially regulate neurotransmitter release

resolves10.1126/science.1166500

Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion

resolves10.1073/pnas.1604348113

N-terminal domain of complexin independently activates calcium-triggered fusion

resolves10.1016/j.bpj.2017.04.002

Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion

resolves10.1016/j.febslet.2009.06.025

A role of complexin–lipid interactions in membrane fusion

resolves10.1016/j.neuron.2012.11.005

Synaptic Vesicles Position Complexin to Block Spontaneous Fusion

resolves10.1038/ncomms5955

Membrane curvature sensing by the C-terminal domain of complexin

resolves10.1073/pnas.1609917113

C-terminal domain of mammalian complexin-1 localizes to highly curved membranes

resolves10.3389/fnmol.2017.00146

Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins

resolves10.1016/j.neuron.2009.09.043

Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis

resolves10.1523/JNEUROSCI.3360-11.2012

C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+Triggering of Synaptic Exocytosis

resolves10.1038/nature23484

The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis

resolves10.1021/ja407392n

Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions

resolves10.1038/nsmb.1446

Complexin and Ca2+ stimulate SNARE-mediated membrane fusion

resolves10.1038/nsmb.2101

Complexin cross-links prefusion SNAREs into a zigzag array

resolves10.1038/nsmb.2103

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

resolves10.1038/nsmb.2102

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

resolves10.7554/eLife.04463

Re-visiting the trans insertion model for complexin clamping

resolves10.7554/eLife.02391

Re-examining how complexin inhibits neurotransmitter release

resolves10.7554/eLife.30286

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes

resolves10.1073/pnas.1409311111

Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo

resolves10.7554/eLife.04553

The accessory helix of complexin functions by stabilizing central helix secondary structure

resolves10.1042/BCJ20160339

Complexin splits the membrane-proximal region of a single SNAREpin

resolves10.7554/eLife.16886

Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex

resolves10.1074/jbc.R100052200

Synaptotagmins: Why So Many?

resolves10.1016/0092-8674(94)90556-8

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

resolves10.1016/j.neuron.2013.10.026

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release

resolves10.1038/nn.2320

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

resolves10.1371/journal.pbio.1002267

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles

resolves10.1038/s41593-017-0037-5

Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment

resolves10.1016/j.cell.2009.07.027

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

resolves10.1016/0092-8674(95)90296-1

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

resolves10.1021/bi981789h

Solution Structures of the Ca2+-free and Ca2+-bound C2A Domain of Synaptotagmin I: Does Ca2+ Induce a Conformational Change?

resolves10.1016/S0896-6273(01)00548-7

Three-Dimensional Structure of the Synaptotagmin 1 C2B-Domain

resolves10.1016/S0896-6273(01)80052-0

Synaptotagmin–Syntaxin Interaction: The C2 Domain as a Ca2+-Dependent Electrostatic Switch

resolves10.1093/emboj/17.14.3921

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2‐domain?

resolves10.1074/jbc.273.22.13995

Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers

resolves10.1021/bi9807512

Mechanism of Phospholipid Binding by the C2A-Domain of Synaptotagmin I

resolves10.1038/35065004

Synaptotagmin I functions as a calcium regulator of release probability

resolves10.1073/pnas.0509153102

Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1

resolves10.1038/nature00846

The C2B Ca2+-binding motif of synaptotagmin is required for synaptic transmission in vivo

resolves10.1523/JNEUROSCI.2545-04.2004

Dual Roles of the C2B Domain of Synaptotagmin I in Synchronizing Ca2+-Dependent Neurotransmitter Release

resolves10.1073/pnas.0908798106

Differential but convergent functions of Ca 2+ binding to synaptotagmin-1 C 2 domains mediate neurotransmitter release

resolves10.1523/JNEUROSCI.4652-11.2012

Calcium Binding by Synaptotagmin's C2A Domain is an Essential Element of the Electrostatic Switch That Triggers Synchronous Synaptic Transmission

resolves10.1038/nature21720

Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP

resolves10.1073/pnas.1710708114

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C 2 A domain in asynchronous neurotransmitter release

resolves10.1038/nsmb709

PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane

resolves10.1074/jbc.M600888200

Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1

resolves10.1038/nsmb1056

Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids

resolves10.1038/nsmb.1508

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function

resolves10.1038/nsmb.3035

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

resolves10.1038/nature14975

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

resolves10.1126/science.1142614

How Synaptotagmin Promotes Membrane Fusion

resolves10.1146/annurev.neuro.26.041002.131412

THE SYNAPTIC VESICLE CYCLE

resolves10.1146/annurev.biochem.77.062005.101135

How Does Synaptotagmin Trigger Neurotransmitter Release?

resolves10.1083/jcb.200203135

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I

resolves10.1126/science.1097196

Reconstitution of Ca 2+ -Regulated Membrane Fusion by Synaptotagmin and SNAREs

resolves10.1126/science.1187722

Dynamic Ca 2+ -Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

resolves10.1038/nsmb.2075

Mechanism and function of synaptotagmin-mediated membrane apposition

resolves10.1038/nsmb.2061

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

resolves10.1038/nsmb.2375

Controlling synaptotagmin activity by electrostatic screening

resolves10.1091/mbc.e05-07-0620

Conserved Prefusion Protein Assembly in Regulated Exocytosis

resolves10.1016/j.jmb.2010.11.015

Synaptotagmin 1 and SNAREs Form a Complex That Is Structurally Heterogeneous

resolves10.1038/emboj.2012.57

Solution single‐vesicle assay reveals PIP2‐mediated sequential actions of synaptotagmin‐1 on SNAREs

resolves10.1021/bi400230u

Analysis of SNARE Complex/Synaptotagmin-1 Interactions by One-Dimensional NMR Spectroscopy

resolves10.1074/jbc.M803355200

Synaptotagmin C2B Domain Regulates Ca2+-triggered Fusion in Vitro

resolves10.1073/pnas.1310327110

Prevalent mechanism of membrane bridging by synaptotagmin-1

resolves10.1038/nsmb.3097

Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength

resolves10.1016/j.jmb.2007.01.040

A Quaternary SNARE–Synaptotagmin–Ca2+–Phospholipid Complex in Neurotransmitter Release

resolves10.1016/j.jmb.2013.07.001

Subtle Interplay between Synaptotagmin and Complexin Binding to the SNARE Complex

resolves10.1038/emboj.2012.164

Complexin arrests a pool of docked vesicles for fast Ca2+‐dependent release

resolves10.7554/eLife.00109

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

resolves10.1021/acs.biochem.6b00114

Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency

resolves10.1038/nsmb.1763

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

resolves10.1523/JNEUROSCI.1011-16.2016

Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission

resolves10.7554/eLife.28409

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion

resolves10.1038/10076

Structure of the Janus-faced C2B domain of rabphilin

resolves10.1523/JNEUROSCI.1911-15.2015

A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells

resolves10.1038/ncomms10971

Different states of synaptotagmin regulate evoked versus spontaneous release

resolves10.1073/pnas.1415849111

Calcium sensitive ring-like oligomers formed by synaptotagmin

resolves10.7554/eLife.27441

Circular oligomerization is an intrinsic property of synaptotagmin

resolves10.1002/1873-3468.12874

Hypothesis – buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission

resolves10.1038/s41593-017-0041-9

Synaptic weight set by Munc13-1 supramolecular assemblies

resolves10.1073/pnas.1708492114

Morphologies of synaptic protein membrane fusion interfaces

resolves10.1016/j.tibs.2014.10.005

How cryo-EM is revolutionizing structural biology

resolves10.1016/j.tcb.2016.08.006

Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail?

resolves10.1371/journal.pone.0022012

Membrane Bridging and Hemifusion by Denaturated Munc18

resolves10.1083/jcb.200908082

Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography

resolves10.1016/j.bbalip.2014.09.017

PI(4,5)P2-binding effector proteins for vesicle exocytosis

resolves10.1016/j.cell.2007.11.002

CAPS-1 and CAPS-2 Are Essential Synaptic Vesicle Priming Proteins

resolves10.3389/fnmol.2017.00380

Productive and Non-productive Pathways for Synaptotagmin 1 to Support Ca2+-Triggered Fast Exocytosis

resolves10.1126/sciadv.1603208

Reconstitution of calcium-mediated exocytosis of dense-core vesicles

resolves10.1021/cn5002667

Amperometric Detection of Single Vesicle Acetylcholine Release Events from an Artificial Cell

resolves10.1016/j.neuron.2012.06.012

The Presynaptic Active Zone

resolves10.1016/j.neuron.2016.07.042

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs

resolves10.15252/embj.201796484

Tyrosine phosphorylation of Munc18‐1 inhibits synaptic transmission by preventing SNARE assembly

What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

checked 2026-07-23 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record

view as graph · paper page

Embed this badge

Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.

<a href="https://citestamp.com/citestamped/10.1002/pro.3445"><img src="https://citestamp.com/citestamped/10.1002/pro.3445/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>

[![CiteStamped reference-health badge](https://citestamp.com/citestamped/10.1002/pro.3445/badge.svg)](https://citestamp.com/citestamped/10.1002/pro.3445)