Reference health
An overview of structure, function, and regulation of pyruvate kinases
79/79 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
9 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 79 checked references that resolve
resolves10.1074/jbc.M111.289033
Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities
resolves10.1038/s41467-017-02086-y
Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
resolves10.1074/jbc.M110.212613
The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site
resolves10.1080/13543776.2018.1391218
Pyruvate kinase activators as a therapy target: a patent review 2011-2017
resolves10.1074/jbc.M109.079905
Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model
resolves10.1016/S1096-4959(03)00081-2
Pyruvate kinase: current status of regulatory and functional properties
resolves10.1021/bi962869t
Metal-Ion-Mediated Allosteric Triggering of Yeast Pyruvate Kinase. 1. A Multidimensional Kinetic Linked-Function Analysis
resolves10.1158/0008-5472.CAN-06-2870
Nuclear Translocation of the Tumor Marker Pyruvate Kinase M2 Induces Programmed Cell Death
resolves10.1017/S003118200400527X
Characterization of a mitochondrion-like organelle in<i>Cryptosporidium parvum</i>
resolves10.1007/s10863-008-9176-4
Mitochondria in malaria and related parasites: ancient, diverse and streamlined
resolves10.1146/annurev.micro.091208.073424
Mitochondrial Evolution and Functions in Malaria Parasites
resolves10.1016/j.protis.2014.08.002
A Unique Hexokinase in Cryptosporidium parvum, an Apicomplexan Pathogen Lacking the Krebs Cycle and Oxidative Phosphorylation
resolves10.1038/nature06734
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
resolves10.1073/pnas.1217157110
M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
resolves10.1016/S0969-2126(98)00021-5
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate
resolves10.1128/JB.182.7.2001-2009.2000
Pyruvate Kinase of the Hyperthermophilic Crenarchaeote
<i>Thermoproteus tenax</i>
: Physiological Role and Phylogenetic Aspects
resolves10.1074/jbc.M210288200
Comparative Analysis of Pyruvate Kinases from the Hyperthermophilic Archaea Archaeoglobus fulgidus, Aeropyrum pernix, and Pyrobaculum aerophilum and the Hyperthermophilic Bacterium Thermotoga maritima
resolves10.1006/abbi.1997.0448
The Monovalent Cation Requirement of Rabbit Muscle Pyruvate Kinase Is Eliminated by Substitution of Lysine for Glutamate 117
resolves10.1111/j.1432-1033.1985.tb09316.x
Stimulation of <i>Trypanosoma brucei</i> pyruvate kinase by fructose 2,6‐bisphosphate
resolves10.1139/o75-061
The Control of Pyruvate Kinases of <i>Escherichia coli</i>. II. Effectors and Regulatory Properties of the Enzyme Activated by Ribose 5-Phosphate
resolves10.1074/jbc.M008878200
Structural and Regulatory Properties of Pyruvate Kinase from the Cyanobacterium Synechococcus PCC 6301
resolves10.1371/journal.pone.0178673
The contribution of two isozymes to the pyruvate kinase activity of Vibrio cholerae: One K+-dependent constitutively active and another K+-independent with essential allosteric activation
resolves10.1074/jbc.M709015200
A Novel GDP-dependent Pyruvate Kinase Isozyme from Toxoplasma gondii Localizes to Both the Apicoplast and the Mitochondrion
resolves10.1016/j.parint.2008.10.005
Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast
resolves10.1042/bj2410573
Purification and kinetic properties of pyruvate kinase isoenzymes of <i>Salmonella typhimurium</i>
resolves10.1371/journal.pone.0119233
New Insights on the Mechanism of the K+-Independent Activity of Crenarchaeota Pyruvate Kinases
resolves10.1111/febs.14837
New views on an old enzyme: allosteric regulation and evolution of archaeal pyruvate kinases
resolves10.1016/j.mib.2005.10.014
Unusual pathways and enzymes of central carbohydrate metabolism in Archaea
resolves10.1128/MMBR.00041-13
Carbohydrate Metabolism in Archaea: Current Insights into Unusual Enzymes and Pathways and Their Regulation
resolves10.1098/rsos.140120
Structures of pyruvate kinases display evolutionarily divergent allosteric strategies
resolves10.1016/j.tmaid.2006.01.015
Plasmodium falciparum pyruvate kinase as a novel target for antimalarial drug-screening
resolves10.1042/bj2380275
Isolation and properties of the glycolytic enzymes from <i>Zymomonas mobilis</i>. The five enzymes from glyceraldehyde-3-phosphate dehydrogenase through to pyruvate kinase
resolves10.1006/prep.1998.0938
Purification and Characterization of Pyruvate Kinase fromSchizosaccharomyces pombe:Evidence for an Unusual Quaternary Structure
resolves10.1006/abbi.2002.2782
Molecular and Regulatory Properties of Leucoplast Pyruvate Kinase from Brassica napus (Rapeseed) Suspension Cells
resolves10.1016/0003-9861(89)90103-3
Pyruvate kinase isozymes from the green alga, Selenastrum minutum
resolves10.1093/jb/mvh152
Possible Structure and Function of the Extra C-Terminal Sequence of Pyruvate Kinase from Bacillus stearothermophilus
resolves10.1111/j.1432-1033.1993.tb17618.x
Molecular cloning and nucleotide sequence of the gene for pyruvate kinase of <i>Bacillus stearothermophilus</i> and the production of the enzyme in <i>Escherichia coli</i>
resolves10.1089/cmb.2015.0143
The DynDom3D Webserver for the Analysis of Domain Movements in Multimeric Proteins
resolves10.1016/S0969-2126(01)00207-6
Crystal structure of Escherichia coli pyruvate kinase type I: molecular basis of the allosteric transition
resolves10.1016/0003-9861(82)90529-X
Kinetic evidence for a dual cation role for muscle pyruvate kinase
resolves10.1016/j.ijbiomac.2010.04.017
The conformational change of rabbit muscle pyruvate kinase induced by activating cations and its substrates
resolves10.1042/bst0150996
Crystallographic studies on the structure and catalytic activity of pyruvate kinase from skeletal muscle
resolves10.1021/bi00186a033
Structure of Rabbit Muscle Pyruvate Kinase Complexed with Mn2+, K+, and Pyruvate
resolves10.1006/abbi.1997.0257
Ligand-Induced Domain Movement in Pyruvate Kinase: Structure of the Enzyme from Rabbit Muscle with Mg2+, K+, andl-Phospholactate at 2.7 Å Resolution
resolves10.1016/j.jmb.2013.02.033
The Origins of Allostery: From Personal Memories to Material for the Future
resolves10.1021/bi00243a010
An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate
resolves10.1016/S0021-9258(18)55378-3
In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate.
resolves10.1016/S0006-8993(03)02239-X
Characterization of the inhibition of pyruvate kinase caused by phenylalanine and phenylpyruvate in rat brain cortex
resolves10.1021/bi0524262
Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase<sup>,</sup>
resolves10.1042/BCJ20180556
Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
resolves10.18632/oncotarget.278
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
resolves10.1007/s13402-018-0383-7
Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target
resolves10.1016/0166-6851(95)02527-8
Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii
The 9 references without a DOI — listed, not checked
no DOI — not checkedLehninger principles of biochemistry
no DOI — not checkedOxidative phosphorylation
no DOI — not checkedPrinciples of biochemistry
no DOI — not checkedBiochemistry: A short course. The glycolytic pathway
no DOI — not checkedThe unusual architecture and predicted function of the mitochondrion organelle in Cryptosporidium parvum and hominis species: The strong paradigm of the structure‐function relationship
no DOI — not checked‘In crystallo’ substrate binding triggers major domain movements and reveals magnesium as a co‐activator of Trypanosoma brucei pyruvate kinase
no DOI — not checkedChanges in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation‐pi bond
no DOI — not checkede_1_2_10_82_1
no DOI — not checkedDouble role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells
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