Reference health
Cyclic‐di‐GMP regulation of virulence in bacterial pathogens
159/159 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 159 checked references that resolve
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Coordinate Regulation of Bacterial Virulence Genes by a Novel Adenylate Cyclase-Dependent Signaling Pathway
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<i>In V</i>
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Characterization of the
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GGDEF and EAL domains inversely regulate cyclic di‐GMP levels and transition from sessility to motility
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<i>Pseudomonas</i>biofilm matrix composition and niche biology
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c-di-GMP and its Effects on Biofilm Formation and Dispersion: a
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The second messenger bis‐(3′‐5′)‐cyclic‐GMP and its PilZ domain‐containing receptor Alg44 are required for alginate biosynthesis in <i>Pseudomonas aeruginosa</i>
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Identification of FleQ from <i>Pseudomonas aeruginosa</i> as a c‐di‐GMP‐responsive transcription factor
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<i>Pseudomonas aeruginosa</i>
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FleQ DNA Binding Consensus Sequence Revealed by Studies of FleQ-Dependent Regulation of Biofilm Gene Expression in Pseudomonas aeruginosa
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Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ from
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Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ
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A cyclic‐di‐GMP receptor required for bacterial exopolysaccharide production
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Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation in Pseudomonas aeruginosa PAO1
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Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa
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A Cyclic di-GMP-binding Adaptor Protein Interacts with Histidine Kinase to Regulate Two-component Signaling
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Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion
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<scp>BrlR</scp> from <scp><i>P</i></scp><i>seudomonas aeruginosa</i> is a c‐di‐<scp>GMP</scp>‐responsive transcription factor
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PilZ Domain Protein FlgZ Mediates Cyclic Di-GMP-Dependent Swarming Motility Control in Pseudomonas aeruginosa
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Dual control of hydrogen cyanide biosynthesis by the global activator GacA in<i>Pseudomonas aeruginosa</i>PAO1
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<i>Pseudomonas aeruginosa</i>
Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung
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Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
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Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
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The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways
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Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
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Cyclic Di-GMP Signaling Contributes to Pseudomonas aeruginosa-Mediated Catheter-Associated Urinary Tract Infection
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Deletion Mutant Library for Investigation of Functional Outputs of Cyclic Diguanylate Metabolism in Pseudomonas aeruginosa PA14
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Direct Evaluation of Pseudomonas aeruginosa Biofilm Mediators in a Chronic Infection Model
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<i>In vivo</i>
functional genomics of
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Psl Produced by Mucoid
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The Pangenome Structure of<i>Escherichia coli</i>: Comparative Genomic Analysis of<i>E. coli</i>Commensal and Pathogenic Isolates
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Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
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Genome-Based Comparison of Cyclic Di-GMP Signaling in Pathogenic and Commensal Escherichia coli Strains
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Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid
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<scp>GIL</scp>, a new c‐di‐<scp>GMP</scp>‐binding protein domain involved in regulation of cellulose synthesis in enterobacteria
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The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism
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Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity
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Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction
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Cyclic‐di‐GMP‐mediated signalling within the σ<sup>S</sup> network of <i>Escherichia coli</i>
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Inverse regulatory coordination of motility and curli-mediated adhesion in <i>Escherichia coli</i>
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Genetic Analysis of the Role of
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in the Ability of Escherichia coli CFT073 To Control Cellular Cyclic Dimeric GMP Levels and To Persist in the Urinary Tract
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Enzymatically Active and Inactive Phosphodiesterases and Diguanylate Cyclases Are Involved in Regulation of Motility or Sessility in Escherichia coli CFT073
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Transcriptional Modulation of Enterotoxigenic Escherichia coli Virulence Genes in Response to Epithelial Cell Interactions
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c-di-GMP signaling regulates E. coli O157:H7 adhesion to colonic epithelium
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Cyclic‐di‐GMP signalling and biofilm‐related properties of the Shiga toxin‐producing 2011 German outbreak Escherichia coli O104:H4
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Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae
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Genetic Requirements for
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Type 3 Fimbrial Shaft (MrkA) of
<i>Klebsiella pneumoniae</i>
, but Not the Fimbrial Adhesin (MrkD), Facilitates Biofilm Formation
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MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression
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Type 3 Fimbriae and Biofilm Formation Are Regulated by the Transcriptional Regulators MrkHI in Klebsiella pneumoniae
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Transcriptional Activation of the mrkA Promoter of the Klebsiella pneumoniae Type 3 Fimbrial Operon by the c-di-GMP-Dependent MrkH Protein
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Role of MrkJ, a Phosphodiesterase, in Type 3 Fimbrial Expression and Biofilm Formation in
<i>Klebsiella pneumoniae</i>
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YjcC, a c-di-GMP Phosphodiesterase Protein, Regulates the Oxidative Stress Response and Virulence of Klebsiella pneumoniae CG43
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Production of Cellulose and Curli Fimbriae by Members of the Family
<i>Enterobacteriaceae</i>
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Quorum Sensing-Dependent Biofilms Enhance Colonization in Vibrio cholerae
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Interaction of cholera toxin and membrane GM1 ganglioside of small intestine.
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Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1
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Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system
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Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model
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Quorum sensing controls biofilm formation in <i>Vibrio cholerae</i>
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Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of <i>Pseudomonas aeruginosa</i> LasR and RhlR
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The structural basis of cyclic diguanylate signal transduction by PilZ domains
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<i>Vibrio cholerae</i>
VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP
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Integration of Cyclic di-GMP and Quorum Sensing in the Control of
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<i>aphA</i>
in Vibrio cholerae
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Cyclic di‐<scp>GMP</scp> inhibits <i><scp>V</scp>ibrio cholerae</i> motility by repressing induction of transcription and inducing extracellular polysaccharide production
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Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems
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C-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in Vibrio cholerae
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Transcriptome and Phenotypic Responses of
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The Mannose-Sensitive Hemagglutinin of<i>Vibrio cholerae</i>Promotes Adherence to Zooplankton
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Role for Mannose-Sensitive Hemagglutinin in Promoting Interactions between
<i>Vibrio cholerae</i>
El Tor and Mussel Hemolymph
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Quorum-regulated biofilms enhance the development of conditionally viable, environmental
<i>Vibrio cholerae</i>
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Bile acids induce cholera toxin expression in
<i>Vibrio cholerae</i>
in a ToxT-independent manner
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<i>Vibrio cholerae</i>
virulence regulator-coordinated evasion of host immunity
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Genes Induced Late in Infection Increase Fitness of Vibrio cholerae after Release into the Environment
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Temperature affects c‐di‐
<scp>GMP</scp>
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<scp>
<i>V</i>
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<i>ibrio cholerae</i>
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Molecular Pathogenesis of<i>Salmonella enterica</i>Serotype Typhimurium-Induced Diarrhea
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Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation
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Salmonella Typhimurium and Multidirectional Communication in the Gut
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Hierarchical involvement of various GGDEF domain proteins in rdar morphotype development of <i>Salmonella enterica</i> serovar Typhimurium
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Complex c-di-GMP Signaling Networks Mediate Transition between Virulence Properties and Biofilm Formation in Salmonella enterica Serovar Typhimurium
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Characterization of the rdar morphotype, a multicellular behaviour in Enterobacteriaceae
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Role of the GGDEF protein family in <i>Salmonella</i> cellulose biosynthesis and biofilm formation
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A Role for the EAL-Like Protein STM1344 in Regulation of CsgD Expression and Motility in<i>Salmonella enterica</i>Serovar Typhimurium
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Role of EAL-Containing Proteins in Multicellular Behavior of<i>Salmonella enterica</i>Serovar Typhimurium
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Dissecting the cyclic di‐guanylate monophosphate signalling network regulating motility in
<i>
<scp>S</scp>
almonella enterica
</i>
serovar
<scp>T</scp>
yphimurium
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The response threshold of <i><scp>S</scp>almonella</i><scp><scp>PilZ</scp></scp> domain proteins is determined by their binding affinities for c‐di‐<scp>GMP</scp>
resolves10.1186/s12934-016-0576-6
BcsZ inhibits biofilm phenotypes and promotes virulence by blocking cellulose production in Salmonella enterica serovar Typhimurium
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Detailed analysis of c-di-GMP mediated regulation of csgD expression in Salmonella typhimurium
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Cyclic di‐GMP signalling controls virulence properties of
<i>Salmonella enterica</i>
serovar Typhimurium at the mucosal lining
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A glutamate‐alanine‐leucine (EAL) domain protein of
<i>Salmonella</i>
controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP
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Bistable Expression of CsgD in Salmonella enterica Serovar Typhimurium Connects Virulence to Persistence
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Salmonella Extracellular Matrix Components Influence Biofilm Formation and Gallbladder Colonization
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Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host
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Risk Factors for Recurrent <i>Clostridium difficile</i> Infection: A Systematic Review and Meta-Analysis
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Virulence factors of Clostridium difficile and their role during infection
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<i>Clostridium difficile</i>virulence factors: Insights into an anaerobic spore-forming pathogen
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Clostridium difficile flagellin stimulates toll-like receptor 5, and toxin B promotes flagellin-induced chemokine production via TLR5
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Identification of a Novel Zinc Metalloprotease through a Global Analysis of Clostridium difficile Extracellular Proteins
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A Novel Secreted Metalloprotease (CD2830) from Clostridium difficile Cleaves Specific Proline Sequences in LPXTG Cell Surface Proteins
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Cyclic diGMP Regulates Production of Sortase Substrates of Clostridium difficile and Their Surface Exposure through ZmpI Protease-mediated Cleavage
resolves10.1007/s00294-015-0484-z
Cyclic-di-GMP signaling in the Gram-positive pathogen Clostridium difficile
resolves10.1126/science.1190713
An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger
resolves10.1371/journal.pgen.1003493
Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile
resolves10.1128/JB.00100-12
Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile
resolves10.1128/JB.00501-13
The Second Messenger Cyclic Di-GMP Regulates Clostridium difficile Toxin Production by Controlling Expression of
<i>sigD</i>
resolves10.1128/IAI.00224-12
Modulation of Toxin Production by the Flagellar Regulon in Clostridium difficile
resolves10.1371/journal.pone.0083748
Characterization of the SigD Regulon of C. difficile and Its Positive Control of Toxin Production through the Regulation of tcdR
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Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile
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Cyclic Di-GMP Binding by an Assembly ATPase (PilB2) and Control of Type IV Pilin Polymerization in the Gram-Positive Pathogen Clostridium perfringens
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Role of the
<b>
<i>Yersinia pestis</i>
</b>
Hemin Storage (
<b>
<i>hms</i>
</b>
) Locus in the Transmission of Plague by Fleas
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Phenotypic Convergence Mediated by GGDEF-Domain-Containing Proteins
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Systematic analysis of cyclic di‐GMP signalling enzymes and their role in biofilm formation and virulence in
<i>Yersinia pestis</i>
resolves10.1371/journal.pone.0019267
Differential Control of Yersinia pestis Biofilm Formation In Vitro and in the Flea Vector by Two c-di-GMP Diguanylate Cyclases
resolves10.1111/j.1365-2958.2004.04253.x
HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms‐dependent biofilm formation in <i>Yersinia pestis</i>
resolves10.1016/j.femsle.2005.04.036
The phosphodiesterase activity of the HmsP EAL domain is required for negative regulation of biofilm formation in<i>Yersinia pestis</i>
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Identification and cloning of a hemin storage locus involved in the pigmentation phenotype of Yersinia pestis
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Yersinia pestis Biofilm in the Flea Vector and Its Role in the Transmission of Plague
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The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi
resolves10.1128/JB.187.5.1792-1798.2005
Cyclic Diguanylate Is a Ubiquitous Signaling Molecule in Bacteria: Insights into Biochemistry of the GGDEF Protein Domain
resolves10.1111/j.1365-2958.2010.07191.x
Analysis of a <i>Borrelia burgdorferi</i> phosphodiesterase demonstrates a role for cyclic‐di‐guanosine monophosphate in motility and virulence
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Analysis of the HD-GYP Domain Cyclic Dimeric GMP Phosphodiesterase Reveals a Role in Motility and the Enzootic Life Cycle of Borrelia burgdorferi
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Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete,<i>Borrelia burgdorferi</i>
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Analysis of the Borrelia burgdorferi Cyclic-di-GMP-Binding Protein PlzA Reveals a Role in Motility and Virulence
resolves10.1111/j.1365-2958.2011.07687.x
The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes
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Cyclic di-GMP Modulates Gene Expression in Lyme Disease Spirochetes at the Tick-Mammal Interface To Promote Spirochete Survival during the Blood Meal and Tick-to-Mammal Transmission
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The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks
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Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks
The 3 references without a DOI — listed, not checked
no DOI — not checkedGlobal regulatory pathways and cross‐talk control Pseudomonas aeruginosa environmental lifestyle and virulence phenotype
no DOI — not checkedMolecular mechanisms of Escherichia coli pathogenicity
no DOI — not checkedHyperinfectivity: a critical element in the ability of V. cholerae to cause epidemics?
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