Reference health

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

140/140 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 140 checked references that resolve

resolves10.1016/j.celrep.2015.12.043

Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α

resolves10.1186/s13059-016-1139-1

Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain

resolves10.4161/rna.24454

Long non-coding RNAs as targets for cytosine methylation

resolves10.1016/0006-3002(58)90214-2

5-Methyl cytosine in the RNA of Escherichia coli

resolves10.15252/embj.201489282

Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders

resolves10.1007/s00018-017-2598-6

The mitochondrial epitranscriptome: the roles of RNA modifications in mitochondrial translation and human disease

resolves10.1371/journal.pone.0133321

Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120

resolves10.1093/nar/gkl765

Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the ${\hbox{ pre-tRNA }}_{\left(\hbox{ CAA }\right)}^{\hbox{ Leu }}$

resolves10.1093/nar/gkh564

Sequence-structure-function studies of tRNA:m5C methyltransferase Trm4p and its relationship to DNA:m5C and RNA:m5U methyltransferases

resolves10.1016/j.cmet.2011.04.002

MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome

resolves10.1098/rsob.160003

Recent advances in dynamic m 6 A RNA modification

resolves10.1038/nature13802

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

resolves10.1093/nar/2.10.1793

Effect of sodium bisulfite modification on the arginine acceptance of E.coli tRNAArg

resolves10.1038/s41467-018-03513-4

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

resolves10.1093/nar/29.18.3784

AdoMet-dependent methylation, DNA methyltransferases and base flipping

resolves10.1016/j.gep.2013.06.003

Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis

resolves10.1093/nar/22.15.2990

High sensitivity mapping of methylated cytosines

resolves10.1016/S0021-9258(18)69432-3

Pseudouridine, a Carbon-Carbon Linked Ribonucleoside in Ribonucleic Acids: Isolation, Structure, and Chemical Characteristics

resolves10.1002/mrd.22600

Nop2 is required for mammalian preimplantation development

resolves10.1016/j.molp.2017.09.013

5-Methylcytosine RNA Methylation in Arabidopsis Thaliana

resolves10.1105/tpc.16.00751

Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs

resolves10.1126/science.aac5253

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

resolves10.1073/pnas.71.10.3971

Identification of Methylated Nucleosides in Messenger RNA from Novikoff Hepatoma Cells

resolves10.1038/nature11112

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

resolves10.1038/cr.2017.73

5-methylcytosine mediates nuclear export of mRNA

resolves10.1093/nar/29.2.439

Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA

resolves10.1093/nar/2.10.1653

The methylation state of poly A-containing-messenger RNA from cultured hamster cells

resolves10.1016/j.celrep.2013.07.046

The RNA Methyltransferase Dnmt2 Is Required for Efficient Dicer-2-Dependent siRNA Pathway Activity in Drosophila

resolves10.1371/journal.pgen.1003602

Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m5C within Archaeal mRNAs

resolves10.1016/S0021-9258(18)69494-3

Polynucleotide Biosynthesis: Formation of a Sequence of Adenylate Units from Adenosine Triphosphate by an Enzyme from Thymus Nuclei

resolves10.3390/biom7010014

Cross-Talk between Dnmt2-Dependent tRNA Methylation and Queuosine Modification

resolves10.1038/nature14275

Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM

resolves10.1128/MCB.4.10.2098

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells.

resolves10.1016/j.stemcr.2016.11.014

Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility

resolves10.1073/pnas.89.5.1827

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

resolves10.1016/j.cub.2006.04.027

The RNA Methyltransferase Misu (NSun2) Mediates Myc-Induced Proliferation and Is Upregulated in Tumors

resolves10.1021/ja505305z

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA

resolves10.4161/rna.27177

Slicing tRNAs to boost functional ncRNA diversity

resolves10.1016/j.celrep.2018.01.061

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

resolves10.1371/journal.pone.0156953

Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth

resolves10.1261/rna.043398.113

A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability

resolves10.1093/nar/gkx470

Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m6A, m5C, m3U, and m5U by top-down mass spectrometry

resolves10.1126/science.1120976

Methylation of tRNA Asp by the DNA Methyltransferase Homolog Dnmt2

resolves10.1038/2171019a0

Amber Suppression: a Nucleotide Change in the Anticodon of a Tyrosine Transfer RNA

resolves10.1038/nchembio.2546

Distinguishing RNA modifications from noise in epitranscriptome maps

resolves10.15252/embj.201694885

NSUN3 and ABH1 modify the wobble position of mt‐tRNAMet to expand codon recognition in mitochondrial translation

resolves10.1261/rna.051524.115

NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs

resolves10.1038/nature21351

Chemical and structural effects of base modifications in messenger RNA

resolves10.1095/biolreprod.106.058669

Sperm Motility Defects and Infertility in Male Mice with a Mutation in Nsun7, a Member of the Sun Domain-Containing Family of Putative RNA Methyltransferases1

resolves10.1038/nchembio.482

Grand Challenge Commentary: RNA epigenetics?

resolves10.1038/nrg.2016.169

Detecting RNA modifications in the epitranscriptome: predict and validate

resolves10.1093/nar/gkv1182

Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code

resolves10.1128/MCB.17.1.378

Nop2p Is Required for Pre-rRNA Processing and 60S Ribosome Subunit Synthesis in Yeast

resolves10.1016/S0021-9258(18)57261-6

THE QUANTITATIVE SEPARATION OF PURINES, PYRIMIDINES, AND NUCLEOSIDES BY PAPER CHROMATOGRAPHY

resolves10.1039/C6SC01589A

Formation and determination of the oxidation products of 5-methylcytosine in RNA

resolves10.1002/cbic.201500013

Formation and Abundance of 5‐Hydroxymethylcytosine in RNA

resolves10.1186/gb4143

Characterizing 5-methylcytosine in the mammalian epitranscriptome

resolves10.1016/j.celrep.2013.06.029

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

resolves10.1128/MCB.01523-12

The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation

resolves10.1080/15476286.2016.1191737

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation

resolves10.1261/rna.970408

Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism

resolves10.1073/pnas.91.25.11797

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.

resolves10.1093/nar/gkx354

ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications

resolves10.1083/jcb.103.3.699

Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA.

resolves10.4161/rna.7.2.11468

Detection of RNA modifications

resolves10.1016/j.ajhg.2012.03.023

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

resolves10.1038/nbt.2566

Identification of direct targets and modified bases of RNA cytosine methyltransferases

resolves10.1016/bs.mie.2015.03.008

Experimental Approaches for Target Profiling of RNA Cytosine Methyltransferases

resolves10.1371/journal.pgen.1003498

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

resolves10.1021/bi026055q

RNA Methyltransferases Utilize Two Cysteine Residues in the Formation of 5-Methylcytosine

resolves10.1101/gr.210666.116

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs

resolves10.1038/ncb3464

A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis

resolves10.1002/jcb.25957

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation

resolves10.1002/wrna.1367

Going global: the new era of mapping modifications in <scp>RNA</scp>

resolves10.1074/jbc.C400477200

DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila

resolves10.1093/nar/gkx473

Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6

resolves10.1073/pnas.97.15.8263

m 5 C RNA and m 5 C DNA methyl transferases use different cysteine residues as catalysts

resolves10.1074/jbc.M116.742569

Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6

resolves10.1371/journal.pone.0110799

Transcriptome-Wide Mapping of Pseudouridines: Pseudouridine Synthases Modify Specific mRNAs in S. cerevisiae

resolves10.1161/CIRCRESAHA.115.307674

NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1

resolves10.1136/jmedgenet-2011-100686

Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome

resolves10.1002/wrna.1266

Small <scp>RNAs</scp> with big implications: new insights into H/<scp>ACA snoRNA</scp> function and their role in human disease

resolves10.1371/journal.pgen.1004110

NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly

resolves10.1146/annurev-cellbio-100616-060758

Rethinking m6A Readers, Writers, and Erasers

resolves10.1016/j.cell.2012.05.003

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

resolves10.1093/nar/gkp1117

5-methylcytosine in RNA: detection, enzymatic formation and biological functions

resolves10.1093/nar/gkv980

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

resolves10.1038/nchembio.2099

NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet

resolves10.1038/nature24482

Visualization of chemical modifications in the human 80S ribosome structure

resolves10.1089/dna.2011.1446

Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers

resolves10.1093/nar/26.11.2536

Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells

resolves10.1016/j.cbpa.2017.10.008

Epitranscriptomics: regulation of mRNA metabolism through modifications

resolves10.1016/0092-8674(75)90068-9

Methylated constituents of heterogeneous nuclear RNA: Presence in blocked 5′ terminal structures

resolves10.1016/0092-8674(75)90159-2

The methylated constituents of L cell messenger RNA: Evidence for an unusual cluster at the 5′ terminus

resolves10.1038/ng.360

Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2

resolves10.1038/nsmb.2992

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

resolves10.1016/S0021-9258(18)34596-4

The effect of bisulfite-induced C to U transitions on aminoacylation of Escherichia coli glycine tRNA.

resolves10.1091/mbc.e06-11-1021

Aurora-B Regulates RNA Methyltransferase NSUN2

resolves10.1016/0092-8674(76)90022-2

Methyl labeling of HeLa cell hnRNA: a comparison with mRNA

resolves10.1186/gb-2012-13-10-175

The birth of the Epitranscriptome: deciphering the function of RNA modifications

resolves10.1200/JCO.1999.17.9.2721

Prognostic Value of Nucleolar Protein p120 in Patients With Resected Lung Adenocarcinoma

resolves10.1016/bs.mie.2015.03.007

RNA 5-Methylcytosine Analysis by Bisulfite Sequencing

resolves10.1093/nar/gkn954

RNA cytosine methylation analysis by bisulfite sequencing

resolves10.1101/gad.586710

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

resolves10.1038/ncomms7158

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

resolves10.1007/s00018-008-8401-y

The genomic basis of the Williams – Beuren syndrome

resolves10.1261/rna.054502.115

Cracking the epitranscriptome

resolves10.1016/j.cell.2014.08.028

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

resolves10.1016/j.celrep.2016.06.014

2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania

resolves10.1038/celldisc.2015.10

Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences

resolves10.1016/j.tibs.2015.07.008

‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification

resolves10.1093/nar/gkt679

Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively

resolves10.1095/biolreprod.103.026880

The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis1

resolves10.1080/15476286.2016.1259781

Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

resolves10.4161/rna.24285

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

resolves10.1021/acschembio.6b00960

Chemical Modifications to RNA: A New Layer of Gene Expression Regulation

resolves10.1093/nar/gks144

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

resolves10.1146/annurev-genet-110410-132531

Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases

resolves10.1093/nar/gkp001

Unconventional decoding of the AUA codon as methionine by mitochondrial tRNA Met with the anticodon f 5 CAU as revealed with a mitochondrial in vitro translation system

resolves10.18632/aging.100860

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation

resolves10.1080/15476286.2017.1318241

The chemistries and consequences of DNA and RNA methylation and demethylation

resolves10.1007/s00018-017-2700-0

RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity

resolves10.15252/embj.201591382

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis

resolves10.1038/nsmb.2357

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

resolves10.1016/S0046-8177(97)90282-3

Significance of the expression of proliferation-associated nucleolar antigen p120 in human colorectal tumors

resolves10.1038/ncomms12039

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

resolves10.3390/biom7010024

Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5‐Formylcytosine Modification in Mitochondrial tRNAMet

resolves10.3390/biom7010029

Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function

resolves10.1016/j.bbrc.2017.09.069

Homocysteine upregulates interleukin-17A expression via NSun2-mediated RNA methylation in T lymphocytes

resolves10.1021/bi00012a031

Origins of the Large Differences in Stability of DNA and RNA Helixes: C-5 Methyl and 2'-Hydroxyl Effects

resolves10.1038/ng1598

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

resolves10.1039/c3an01224g

The global identification of tRNA isoacceptors by targeted tandem mass spectrometry

resolves10.1093/nar/23.2.203

The fission yeast gene pmt1+encodes a DNA methyltransferase homologue

resolves10.1016/S0378-1119(98)00330-8

NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae

resolves10.1038/166237b0

Occurrence of 5-Methyl-Cytosine in Nucleic Acids

resolves10.1128/MCB.00742-15

NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation

resolves10.1016/j.cbpa.2018.06.017

N1-methyladenosine methylome in messenger RNA and non-coding RNA

resolves10.1038/cr.2017.55

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

resolves10.1002/ange.19660780714

Nucleotidsequenzen zweier serinspezifischer Transfer‐Ribonucleinsäuren

resolves10.1038/nrm.2016.132

Post-transcriptional gene regulation by mRNA modifications

The 3 references without a DOI — listed, not checked

no DOI — not checkedExpression of human proliferation‐associated nucleolar antigen p120

no DOI — not checkedCooperativity between different tRNA modifications and their modification pathways

no DOI — not checkedExpression of nucleolar protein p120 in human lung cancer: Difference in histological types as a marker for proliferation

What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

checked 2026-07-23 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record

view as graph · paper page

Embed this badge

Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.

<a href="https://citestamp.com/citestamped/10.1002/wrna.1510"><img src="https://citestamp.com/citestamped/10.1002/wrna.1510/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>

[![CiteStamped reference-health badge](https://citestamp.com/citestamped/10.1002/wrna.1510/badge.svg)](https://citestamp.com/citestamped/10.1002/wrna.1510)