Reference health
Tetracycline use in treating osteoarthritis: a systematic review
59/59 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
8 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 59 checked references that resolve
resolves10.1016/j.joca.2012.11.012
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
resolves10.1002/jor.24457
Role of Inflammation and the Immune System in the Progression of Osteoarthritis
resolves10.1111/cod.12868
9‐<i>cis</i>‐<scp>R</scp>etinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed‐type allergy
resolves10.1186/s13075-019-1923-x
Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation
resolves10.1002/art.39006
Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis
resolves10.1002/art.27475
Chondrocyte innate immune myeloid differentiation factor 88–dependent signaling drives procatabolic effects of the endogenous toll‐like receptor 2/toll‐like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice
resolves10.1002/art.22042
Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products
resolves10.1016/j.joca.2018.08.005
Biomarkers of inflammation – LBP and TLR— predict progression of knee osteoarthritis in the DOXY clinical trial
resolves10.1016/j.bbapap.2011.06.020
Proteases involved in cartilage matrix degradation in osteoarthritis
resolves10.1002/art.27582
Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice
resolves10.1016/j.joca.2018.01.017
Molecular influence of anterior cruciate ligament tear remnants on chondrocytes: a biologic connection between injury and osteoarthritis
resolves10.3390/cells8090984
The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma
resolves10.1016/j.phrs.2011.06.010
The road forward: The scientific basis for tetracycline treatment of arthritic disorders
resolves10.1002/1529-0131(199906)42:6<1140::AID-ANR10>3.0.CO;2-7
Specificity of inhibition of matrix metalloproteinase activity by doxycycline: Relationship to structure of the enzyme
resolves10.1002/1529-0131(199904)42:4<719::AID-ANR15>3.0.CO;2-T
Differential patterns of response to doxycycline and transforming growth factor ?1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes
resolves10.1371/journal.pone.0174853
Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study
resolves10.1128/AAC.40.4.934
The tetracycline derivative minocycline differentially affects cytokine production by monocytes and T lymphocytes
resolves10.1073/pnas.93.24.14014
A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
resolves10.1007/PL00000263
Tetracyclines inhibit nitrosothiol production by cytokine-stimulated osteoarthritic synovial cells
resolves10.1002/jor.21026
In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage
resolves10.1016/j.joca.2012.11.010
Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair
resolves10.1186/1746-6148-9-68
Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis
resolves10.1002/jbm.b.33303
<scp><i>I</i></scp><i>n vitro</i> and <i>in vivo</i> evaluation of doxycycline‐chondroitin sulfate/<scp>PCL</scp>microspheres for intraarticular treatment of osteoarthritis
resolves10.1002/art.1780351007
Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline
resolves10.5402/2012/182097
An Assessment of the Chondroprotective Effects of Intra-Articular Application of Statin and Tetracycline on Early-Stage Experimental Osteoarthritis
resolves10.1016/j.mri.2011.09.025
Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis
resolves10.1177/08959374980120012001
The Potential Role of Doxycycline in the Treatment of Osteoarthritis of the Temporomandibular Joint
resolves10.1002/art.21122
Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo‐controlled, double‐blind trial
resolves10.1136/ard.2010.147967
The effects of doxycycline on reducing symptoms in knee osteoarthritis: results from a triple-blinded randomised controlled trial
resolves10.1097/RHU.0000000000000095
Pilot Open Observations on Doxycycline Treatment for Erosive Osteoarthritis of the Hand
resolves10.7326/0003-4819-122-2-199501150-00001
Minocycline in Rheumatoid Arthritis: A 48-Week, Double-Blind, Placebo-Controlled Trial
resolves10.1002/art.1780400510
Treatment of early Rheumatoid Arthritis with minocycline or placebo. Results of a Randomized, double‐blind, placebo‐controlled trial
resolves10.1002/1529-0131(199908)42:8<1691::AID-ANR18>3.0.CO;2-S
Treatment of early seropositive rheumatoid arthritis with minocycline: Four-year followup of a double-blind, placebo-controlled trial
resolves10.1002/1529-0131(200110)44:10<2235::AID-ART385>3.0.CO;2-A
Treatment of early seropositive rheumatoid arthritis: A two-year, double-blind comparison of minocycline and hydroxychloroquine
resolves10.1056/NEJMoa0800777
Incidental Meniscal Findings on Knee MRI in Middle-Aged and Elderly Persons
resolves10.1249/MSS.0000000000002161
Dysregulated Inflammatory Response Related to Cartilage Degradation after ACL Injury
resolves10.1016/j.joca.2013.11.002
Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis
resolves10.1002/art.11326
The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis
resolves10.1136/ard.2011.150953
Why should we expect a structure-modifying osteoarthritis drug to relieve osteoarthritis pain?
resolves10.1002/art.37987
Magnetic Resonance Imaging–Based Three‐Dimensional Bone Shape of the Knee Predicts Onset of Knee Osteoarthritis: Data From the Osteoarthritis Initiative
resolves10.4103/1673-5374.206633
Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury
resolves10.1186/1744-8069-7-88
The Contribution of Spinal Glial Cells to Chronic Pain Behaviour in the Monosodium Iodoacetate Model of Osteoarthritic Pain
resolves10.1186/1741-7015-11-200
So depression is an inflammatory disease, but where does the inflammation come from?
resolves10.1016/j.biopsych.2017.08.005
Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study
resolves10.1007/s11126-019-09707-3
Minocycline for Depressive Symptoms: a Meta-Analysis of Randomized, Double-Blinded, Placebo-Controlled Trials
resolves10.1038/s41398-019-0556-9
Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner
resolves10.1093/eurheartj/eht420
Early short-term doxycycline therapy in patients with acute myocardial infarction and left ventricular dysfunction to prevent the ominous progression to adverse remodelling: the TIPTOP trial
resolves10.1016/j.phrs.2011.05.002
Matrix metalloproteinase inhibition with tetracyclines for the treatment of coronary artery disease
resolves10.1016/j.anaerobe.2017.12.011
An in vitro study to assess the impact of tetracycline on the human intestinal microbiome
resolves10.1016/j.envint.2019.104989
Low-dose tetracycline exposure alters gut bacterial metabolism and host-immune response: “Personalized” effect?
The 8 references without a DOI — listed, not checked
no DOI — not checkedGreenwald RA, Golub LM, Lavietes B, Ramamurthy NS, Gruber B, Laskin RS, et al. Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J Rheumatol. 1987;14:28–32.
no DOI — not checkedYu LP Jr, Smith GN Jr, Hasty KA, Brandt KD. Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase. J Rheumatol. 1991;18:1450–2.
no DOI — not checkedSmith GN Jr, Yu LP Jr, Brandt KD, Capello WN. Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage. J Rheumatol. 1998;25:532–5.
no DOI — not checkedShlopov BV, Stuart JM, Gumanovskaya ML, Hasty KA. Regulation of cartilage collagenase by doxycycline. J Rheumatol. 2001;28:835–42.
no DOI — not checkedKloppenburg M, Breedveld FC, Miltenburg AM, Dijkmans BA. Antibiotics as disease modifiers in arthritis. Clin Exp Rheumatol. 1993;11(Suppl 8):S113–5.
no DOI — not checkedPardy CK, Matyas JR, Zernicke RF. Doxycycline effects on mechanical and morphometrical properties of early- and late-stage osteoarthritic bone following anterior cruciate ligament injury. J Appl Physiol. 1985;2004(97):1254–60.
no DOI — not checkedStone M, Fortin PR, Pacheco-Tena C, Inman RD. Should tetracycline treatment be used more extensively for rheumatoid arthritis? Metaanalysis demonstrates clinical benefit with reduction in disease activity. J Rheumatol. 2003;30:2112–22.
no DOI — not checkedGossage DL, Cieslarova B, Ap S, Zheng H, Xin Y, Lal P, et al. Phase 1b study of the safety, pharmacokinetics, and disease-related outcomes of the matrix metalloproteinase-9 inhibitor andecaliximab in patients with rheumatoid arthritis. Clin Ther. 2018;40(156–165):e5.
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