Reference health
Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase
1 of 53 checkable references need attention · checked 2026-07-22
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
marked retracted by the publisher10.1042/BJ20131478
The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl− co-transporters
The 52 checked references that resolve
resolves10.1097/CAD.0b013e3283609ec1
Chemotherapy in metastatic renal cell carcinoma today? A systematic review
resolves10.1016/j.clindermatol.2012.08.016
Chemotherapy in the management of advanced cutaneous malignant melanoma
resolves10.1634/theoncologist.2010-0190
Systematic Review of Medical Treatment in Melanoma: Current Status and Future Prospects
resolves10.1056/NEJMoa1103782
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
resolves10.1016/S0140-6736(12)60868-X
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
resolves10.1016/j.ctrv.2013.09.003
Targeted therapies and complete responses in first line treatment of metastatic renal cell carcinoma. A meta-analysis of published trials
resolves10.1586/era.12.81
Primary resistance to tyrosine kinase inhibitors in patients with advanced renal cell carcinoma: state-of-the-science
resolves10.1016/j.ctrv.2012.01.003
Overcoming resistance to tyrosine kinase inhibitors in renal cell carcinoma
resolves10.1016/j.ctrv.2012.06.010
What is the optimal therapy for patients with metastatic renal cell carcinoma who progress on an initial VEGFr-TKI?
resolves10.1002/ijc.28023
Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to VEGFR and mTORC1 inhibitors
resolves10.1152/ajpcell.00102.2011
Ion channels and tranporters in cancer. 2. Ion channels and the control of cancer cell migration
resolves10.1098/rstb.2013.0109
Ion channels and transporters in the development of drug resistance in cancer cells
resolves10.1021/np200906s
Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
resolves10.1016/j.phytochem.2003.11.006
Studies on structure–activity relationship of sphaeropsidins A–F, phytotoxins produced by Sphaeropsis sapinea f. sp. cupressi
resolves10.1021/np500258r
Diplopimarane, a 20<i>-nor-ent</i>-Pimarane Produced by the Oak Pathogen <i>Diplodia quercivora</i>
resolves10.1021/np2000864
Smardaesidins A–G, Isopimarane and 20-<i>nor</i>-Isopimarane Diterpenoids from Smardaea sp., a Fungal Endophyte of the Moss Ceratodon purpureus
resolves10.1016/j.phytol.2012.08.011
Evaluation of in vitro anticancer activity of sphaeropsidins A–C, fungal rearranged pimarane diterpenes, and semisynthetic derivatives
resolves10.1038/sj.jid.5700869
Galectin-1 Knockdown Increases Sensitivity to Temozolomide in a B16F10 Mouse Metastatic Melanoma Model
resolves10.1016/j.yexcr.2009.07.021
KCa2.3 channel-dependent hyperpolarization increases melanoma cell motility
resolves10.1093/jnci/81.14.1088
Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm
resolves10.1021/jm300542e
Novel Trisubstituted Harmine Derivatives with Original in Vitro Anticancer Activity
resolves10.1021/jm400287v
New 5-Aryl-1<i>H</i>-imidazoles Display in Vitro Antitumor Activity against Apoptosis-Resistant Cancer Models, Including Melanomas, through Mitochondrial Targeting
resolves10.1016/j.canlet.2009.02.048
The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells
resolves10.1152/ajplung.00041.2003
Activation of K<sup>+</sup>channels: an essential pathway in programmed cell death
resolves10.1007/s00232-005-0836-6
Volume-sensitive Chloride Channels Involved in Apoptotic Volume Decrease and Cell Death
resolves10.1016/S1095-6433(01)00424-X
Apoptosis, cell volume regulation and volume-regulatory chloride channels
resolves10.1007/s10495-012-0716-3
Early-phase occurrence of K+ and Cl− efflux in addition to Ca2+ mobilization is a prerequisite to apoptosis in HeLa cells
resolves10.1159/000335843
Ion Channels Involved in Cell Volume Regulation: Effects on Migration, Proliferation, and Programmed Cell Death in Non Adherent EAT Cells and Adherent ELA Cells
resolves10.1136/jcp.2005.033100
Furosemide reverses multidrug resistance status in bladder cancer cells in vitro
resolves10.1159/000339047
Inhibition of Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup></sup>Cotransporter isoform 1 Accelerates Temozolomidemediated Apoptosis in Glioblastoma Cancer Cells
resolves10.1113/jphysiol.2010.190769
Kinase regulation of Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup>−</sup>cotransport in primary afferent neurons
resolves10.1152/physiolgenomics.2001.5.3.119
VHL tumor suppressor regulates Cl<sup>−</sup>/HCO<sub>3</sub><sup>−</sup>exchange and Na<sup>+</sup>/H<sup>+</sup>exchange activities in renal carcinoma cells
resolves10.1021/bi00092a014
Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein
resolves10.1021/bi00202a021
Novel Cl--Dependent Intracellular pH Regulation in Murine MDR 1 Transfectants and Potential Implications
resolves10.1021/bi00189a028
Transfection of mu MDR 1 Inhibits Na+-Independent Cl-/-HCO3 Exchange in Chinese Hamster Ovary Cells
resolves10.1152/ajpcell.00654.2008
Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels
resolves10.1007/s11010-007-9619-y
Anion exchanger inhibitor DIDS induces human poorly-differentiated malignant hepatocellular carcinoma HA22T cell apoptosis
resolves10.1007/s11010-009-0051-3
Reduction of anion exchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells
resolves10.1016/j.bbrc.2003.09.200
HNF1α upregulates the human AE2 anion exchanger gene (SLC4A2) from an alternate promoter
resolves10.1158/0008-5472.CAN-09-4666
Inhibition of the Sodium-Potassium-Chloride Cotransporter Isoform-1 Reduces Glioma Invasion
resolves10.1186/1476-4598-13-31
WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
resolves10.1152/ajpcell.00203.2011
With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume
resolves10.1186/1471-2415-11-33
DPOFA, a Cl-/HCO3
-exchanger antagonist, stimulates fluid absorption across basolateral surface of the retinal pigment epithelium
resolves10.1074/jbc.M109.014217
Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle
The 2 references without a DOI — listed, not checked
no DOI — not checkedLee AH, Tannock IF (1998) Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res 58:1901–1908
no DOI — not checkedPogorevici A, Velciov SM, Secrii RV (2007) The molecular and physiopathological mechanisms involved in response reduction to chronic diuretics therapy. TMJ 57:58–67
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