Reference health
Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia
56/56 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 56 checked references that resolve
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Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway
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Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
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Passage of spermidine across the blood–brain barrier in short recirculation periods following global cerebral ischemia: effects of mild hyperthermia
resolves10.1016/j.nbd.2013.11.002
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
resolves10.1186/1758-5996-3-16
Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
resolves10.5301/JN.2011.8345
Tert-Butylhydroquinone pretreatment protects kidney from ischemia-reperfusion injury
resolves10.1016/j.jep.2013.11.026
Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats
resolves10.1161/01.HYP.0000221429.94591.72
Metformin Inhibits Cytokine-Induced Nuclear Factor κB Activation Via AMP-Activated Protein Kinase Activation in Vascular Endothelial Cells
resolves10.1111/jnc.12362
AMP‐activated protein kinase counteracts brain‐derived neurotrophic factor‐induced mammalian target of rapamycin complex 1 signaling in neurons
resolves10.1021/bi400399f
Role of AMP-Activated Protein Kinase in Ferritin H Gene Expression by Resveratrol in Human T Cells
resolves10.1016/j.abb.2011.05.016
Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages
resolves10.1016/j.jss.2013.10.009
Fish-oil emulsion (omega-3 polyunsaturated fatty acids) attenuates acute lung injury induced by intestinal ischemia–reperfusion through Adenosine 5′-monophosphate-activated protein kinase–sirtuin1 pathway
resolves10.1002/dmrr.1185
Effects of insulin and oral anti‐diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects
resolves10.1016/j.ejpb.2013.02.005
Curcumin loaded solid lipid nanoparticles: An efficient formulation approach for cerebral ischemic reperfusion injury in rats
resolves10.1093/cvr/cvp166
AMP-activated protein kinase confers protection against TNF-α-induced cardiac cell death
resolves10.1016/j.brainres.2013.06.041
Gemfibrozil pretreatment proved protection against acute restraint stress-induced changes in the male rats' hippocampus
resolves10.1002/jcb.22486
Improved myocardial perfusion in chronic diabetic mice by the up‐regulation of pLKB1 and AMPK signaling
resolves10.1016/j.neuro.2009.10.006
AICAR (5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures
resolves10.1016/S1734-1140(10)70357-1
Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide
resolves10.1523/JNEUROSCI.0802-07.2007
Contribution of Downregulation of L-type Calcium Currents to Delayed Neuronal Death in Rat Hippocampus after Global Cerebral Ischemia and Reperfusion
resolves10.1016/j.ijdevneu.2014.08.005
Sevoflurane postconditioning attenuates cerebral ischemia‐reperfusion injury via protein kinase B/nuclear factor‐erythroid 2‐related factor 2 pathway activation
resolves10.1002/path.2754
Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity
resolves10.1016/S1262-3636(03)72790-6
Antiatherogenic properties of metformin: the experimental evidence
resolves10.1002/jnr.23207
Function of the master energy regulator adenosine monophosphate‐activated protein kinase in stroke
resolves10.1074/jbc.M409985200
Pharmacological Inhibition of AMP-activated Protein Kinase Provides Neuroprotection in Stroke
resolves10.1038/nature06504
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
resolves10.1007/s12640-012-9338-3
Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia–Reperfusion
resolves10.1038/sj.jcbfm.9600287
Prevention of Apoptosis-Inducing Factor Translocation is a Possible Mechanism for Protective Effects of Hepatocyte Growth Factor against Neuronal Cell Death in the Hippocampus after Transient Forebrain Ischemia
resolves10.1371/journal.pone.0008758
Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
resolves10.1016/j.ajpath.2013.04.030
AMP-Activated Protein Kinase Signaling Protects Oligodendrocytes that Restore Central Nervous System Functions in an Experimental Autoimmune Encephalomyelitis Model
resolves10.1161/01.STR.10.3.267
A new model of bilateral hemispheric ischemia in the unanesthetized rat.
resolves10.1016/j.jpain.2013.05.012
Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception
resolves10.1016/j.arr.2011.12.005
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
resolves10.1111/j.1471-4159.2011.07331.x
AMP‐activated protein kinase: a potential player in Alzheimer’s disease
resolves10.1152/ajprenal.00420.2010
Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia
resolves10.1161/01.STR.28.3.491
Comparable Studies of the Incidence of Stroke and its Pathological Types
resolves10.1016/j.neuint.2012.11.017
Ginkgo biloba prevents transient global ischemia-induced delayed hippocampal neuronal death through antioxidant and anti-inflammatory mechanism
resolves10.4161/cc.8.1.7499
The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
resolves10.1152/ajpheart.00101.2013
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats
resolves10.1038/sj.onc.1202237
Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
resolves10.1038/sj.jcbfm.9600234
Normoxic Resuscitation after Cardiac Arrest Protects against Hippocampal Oxidative Stress, Metabolic Dysfunction, and Neuronal Death
resolves10.1016/j.ejphar.2013.10.016
Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica
resolves10.1002/hipo.22126
Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling
resolves10.1371/journal.pone.0071773
Metformin Protects Rat Hepatocytes against Bile Acid-Induced Apoptosis
resolves10.1002/mnfr.201200809
AMPK synergizes with the combined treatment of 1′‐acetoxychavicol acetate and sodium butyrate to upregulate phase II detoxifying enzyme activities
resolves10.1007/s00395-011-0216-6
The potential effects of anti-diabetic medications on myocardial ischemia–reperfusion injury
resolves10.1038/sj.emboj.7600244
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
resolves10.5115/acb.2011.44.3.194
Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells
resolves10.1158/1940-6207.CAPR-13-0337
Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment
The 3 references without a DOI — listed, not checked
no DOI — not checkedFeuerstein GZ, Liu T, Barone FC (1994) Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha. Cerebrovasc Brain Metab Rev 6:341–360
no DOI — not checkedJiang T, Yu JT, Zhu XC, Wang HF, Tan MS, Cao L, Zhang QQ, Gao L, Shi JQ, Zhang YD, Tan L (2014) Acute metformin preconditioning confers neuroprotection against focal cerebral ischemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol. doi: 10.1111/bph.12655
no DOI — not checkedStoll G, Jander S, Schroeter M (2002) Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. Adv Exp Med Biol 513:87–113
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