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A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
20/20 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 20 checked references that resolve
resolves10.1056/NEJMoa1611618
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
resolves10.1212/WNL.0000000000005254
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome
resolves10.1016/S0140-6736(18)30136-3
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial
resolves10.1210/me.2011-1197
Minireview: Recent Developments in the Physiology and Pathology of the Lysophosphatidylinositol-Sensitive Receptor GPR55
resolves10.1073/pnas.1211204110
Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses
resolves10.1111/bph.12944
Are cannabidiol and Δ<sup>9</sup>‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review
resolves10.1016/j.lfs.2011.05.018
Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
resolves10.1124/dmd.109.026898
Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
resolves10.3109/03602532.2013.849268
Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review
resolves10.1111/epi.13060
Drug–drug interaction between clobazam and cannabidiol in children with refractory epilepsy
resolves10.2174/157488611798280924
Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
resolves10.1111/epi.13499
Cannabidiol as a new treatment for drug‐resistant epilepsy in tuberous sclerosis complex
resolves10.1016/S1474-4422(15)00379-8
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial
resolves10.1016/j.eplepsyres.2016.10.020
The application of half-life in clinical decision making: Comparison of the pharmacokinetics of extended-release topiramate (USL255) and immediate-release topiramate
The 2 references without a DOI — listed, not checked
no DOI — not checkedZuardi AW, Morais SL, Guimarães FS, Mechoulam R. Antipsychotic effect of cannabidiol. J Clin Psychiatry. 1995;56(10):485–6.
no DOI — not checkedWhalley BJ, Stott C, Gray RA. The human metabolite of cannabidiol, 7-hydroxy-cannabidiol, but not 7-carboxy-cannabidiol, is anticonvulsant in the maximal electroshock threshold test (MEST) in mouse [abstract no. 1.435]. AES Conference; 2017.
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