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Safety of Oral Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Osteoarthritis: What Does the Literature Say?

https://doi.org/10.1007/s40266-019-00660-1
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43/43 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

4 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 43 checked references that resolve
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An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
resolves10.1016/j.joca.2014.01.003
OARSI guidelines for the non-surgical management of knee osteoarthritis
resolves10.1002/acr.21596
American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee
resolves10.1136/ard.2003.011742
EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
resolves10.1111/j.1533-2500.2012.00532.x
Use and Costs of Prescription Medications and Alternative Treatments in Patients with Osteoarthritis and Chronic Low Back Pain in Community‐Based Settings
resolves10.1093/rheumatology/ket463
Osteoarthritis in Europe: impact on health status, work productivity and use of pharmacotherapies in five European countries
resolves10.1186/ar4286
How do people with knee osteoarthritis use osteoarthritis pain medications and does this change over time? Data from the Osteoarthritis Initiative
resolves10.1111/j.1526-4637.2009.00699.x
Pharmacological Management of Persistent Pain in Older Persons
resolves10.1002/art.21328
Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: Case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis
resolves10.2165/11539430-000000000-00000
Should Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) be Prescribed to the Older Adult?
resolves10.1016/j.semarthrit.2015.11.010
A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis—From evidence-based medicine to the real-life setting
resolves10.1007/s40266-019-00664-x
Safety of Cyclooxygenase-2 Inhibitors in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis
resolves10.1136/bmj.332.7553.1302
Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials
resolves10.1001/jama.296.13.jrv60011
Cardiovascular Risk and Inhibition of Cyclooxygenase
resolves10.1111/j.1742-7843.2006.pto_302.x
Non‐Steroidal Antiinflammatory Drugs and the Risk of Acute Myocardial Infarction
resolves10.1016/j.cgh.2007.03.011
Gastrointestinal Safety of Cyclooxygenase-2 Inhibitors: A Cochrane Collaboration Systematic Review
resolves10.1016/j.semarthrit.2007.10.004
COX-2 Selective Inhibitors in the Treatment of Osteoarthritis
resolves10.1136/bmj.d1165
All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study
resolves10.1136/bmj.d1407
Excess mortality in osteoarthritis
resolves10.1371/journal.pone.0091286
All-Cause Mortality and Serious Cardiovascular Events in People with Hip and Knee Osteoarthritis: A Population Based Cohort Study
resolves10.1016/j.semarthrit.2016.04.002
Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis
resolves10.1136/annrheumdis-2015-208056
Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women
resolves10.1136/annrheumdis-2013-203789
Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham Heart Study
resolves10.1136/rmdopen-2016-000344
Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study
resolves10.18433/J3VW2F
Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications
resolves10.1016/j.yjmcc.2016.03.016
Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells
resolves10.1056/NEJMoa050493
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
resolves10.1016/s0140-6736(13)60900-9
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials
resolves10.1097/MEG.0b013e328349de81
Meta-analysis
resolves10.1185/03007995.2011.581274
Gastrointestinal tolerability of NSAIDs in elderly patients: a pooled analysis of 21 randomized clinical trials with celecoxib and nonselective NSAIDs
resolves10.1111/jcpt.12484
Non-steroidal anti-inflammatory drug-induced cardiovascular adverse events: a meta-analysis
resolves10.1056/NEJMoa1611593
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis
resolves10.1136/bmj.j1909
Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data
resolves10.1002/clc.22502
Nonsteroidal Anti‐inflammatory Drugs and Risk of Incident Heart Failure: A Systematic Review and Meta‐analysis of Observational Studies
resolves10.1161/STROKEAHA.115.011678
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke
resolves10.1161/CIRCULATIONAHA.105.568451
Cyclooxygenase Inhibition and Cardiovascular Risk
resolves10.1111/j.1464-410X.2012.11679_4.x
Cardiovascular risk with nonsteroidal anti‐inflammatory drugs ( <scp>NSAIDs</scp> ): the urological perspective
resolves10.1016/j.ejim.2015.03.008
Individual non-steroidal anti-inflammatory drugs and risk of acute kidney injury: A systematic review and meta-analysis of observational studies
resolves10.1111/jgs.12148
Greater Number of Narcotic Analgesic Prescriptions for Osteoarthritis Is Associated with Falls and Fractures in Elderly Adults
resolves10.2174/092986710790416326
Age-Related Pharmacokinetic and Pharmacodynamic Changes and Related Risk of Adverse Drug Reactions
resolves10.1016/j.jpainsymman.2006.05.015
Opioid Escalation in Patients with Cancer Pain: The Effect of Age
resolves10.1001/archinternmed.2010.391
The Comparative Safety of Analgesics in Older Adults With Arthritis
resolves10.1016/j.amjmed.2016.09.006
Intermittent Nitrate Use and Risk of Hip Fracture
The 4 references without a DOI — listed, not checked
no DOI — not checkedNational Institute for Health and Care Excellence. Osteoarthritis care and management in adults: Methods, evidence and recommendations. National Clinical Guideline Centre. London: National Institute for Health and Care Excellence; 2014: Report no. CG177.
no DOI — not checkedChou R, McDonagh MS, Nakamoto E, Griffin J. Analgesics for osteoarthritis: an update of the 2006 Comparative Effectiveness Review. Comparative Effectiveness Review No. 38. October 2011. AHRQ Publication No. 11(12)-EHC076-EF. Rockville (MD): Agency for Healthcare Research and Quality. Available from: https://www.ncbi.nlm.nih.gov/books/NBK65646/pdf/Bookshelf_NBK65646.pdf . Accessed 27 Apr 2018.
no DOI — not checkedHochberg MC. Mortality in osteoarthritis. Clin Exp Rheumatol. 2008;26(5 Suppl. 51):S120–4.
no DOI — not checkedLeyland KM, Gates LS, Sanchez-Santos MT, Prieto-Alhambra D, Judge A, Collins G, et al. The association of knee osteoarthritis and premature mortality in the community: an international individual patient level meta-analysis in six prospective cohorts. Osteoporos Int. 2017;28(Suppl. 1):abstract no. OC10.
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