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NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model

https://doi.org/10.1016/j.bbr.2017.01.018

45/45 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 45 checked references that resolve

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Symmetrical treatment of “Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition”, for major depressive disorders

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Epidemiology of Major Depressive Disorder in Mainland China: A Systematic Review

resolves10.1001/jama.289.23.3095

The Epidemiology of Major Depressive Disorder

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Evidence for an immune response in major depression: A review and hypothesis

resolves10.1016/j.bbi.2010.10.008

Immune suppression and immune activation in depression

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A Meta-Analysis of Cytokines in Major Depression

resolves10.2174/187152808784165216

Inflammatory Aspects of Depression

resolves10.1001/archpsyc.58.5.445

Cytokine-Associated Emotional and Cognitive Disturbances in Humans

resolves10.1038/sj.mp.4002055

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

resolves10.1016/j.cell.2010.01.040

The Inflammasomes

resolves10.1016/j.smim.2009.05.002

The NLRP3 inflammasome: A sensor of immune danger signals

resolves10.1016/j.biocel.2010.01.008

Nlrp3: An immune sensor of cellular stress and infection

resolves10.1016/j.bbi.2012.12.008

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

resolves10.1093/ijnp/pyv006

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

resolves10.1111/cns.12170

Involvement of Inflammasome Activation in Lipopolysaccharide‐induced Mice Depressive‐like Behaviors

resolves10.1007/s12035-015-9408-7

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

resolves10.1016/j.biopsych.2015.11.026

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

resolves10.1038/srep23742

Effects of hydrogen-rich water on depressive-like behavior in mice

resolves10.1111/imm.12443

Immune mechanisms linked to depression via oxidative stress and neuroprogression

resolves10.18632/oncotarget.8202

Genetic overlap between type 2 diabetes and major depressive disorder identified by bioinformatics analysis

resolves10.1073/pnas.0401060101

Canonical pathway of nuclear factor κB activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis

resolves10.1016/j.biopsych.2008.10.018

The Interaction of Nuclear Factor-Kappa B and Cytokines Is Associated with Schizophrenia

resolves10.1159/000362841

Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients

resolves10.1038/tp.2015.15

Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes

resolves10.1186/s12974-016-0539-1

Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome

resolves10.3724/SP.J.1008.2014.00555

Breeding and genotype identification of <i>NLRP</i> 3 gene knock-out mice

resolves10.1186/1742-2094-9-75

Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress

resolves10.1017/S1461145714000285

Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis

resolves10.31887/DCNS.2006.8.4/ssmith

The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

resolves10.1016/j.yfrne.2008.10.001

Interleukin-1 (IL-1): A central regulator of stress responses

resolves10.1073/pnas.0708092105

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

resolves10.1038/nn.3262

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

resolves10.4049/jimmunol.0901363

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

resolves10.1074/jbc.M109.082305

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

resolves10.1146/annurev.iy.12.040194.001041

Function and Activation of NF-kappaB in the Immune System

resolves10.1016/S0092-8674(00)81318-5

NF-κB: Ten Years After

resolves10.1126/science.1072682

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

resolves10.1523/JNEUROSCI.4965-11.2013

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

resolves10.1038/nrd2289

Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses

resolves10.1038/nm.2219

A negative regulator of MAP kinase causes depressive behavior

resolves10.1089/jwh.2015.5214

Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women

resolves10.1371/journal.pone.0130624

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

resolves10.1038/mp.2013.155

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

resolves10.1002/glia.22891

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

The 2 references without a DOI — listed, not checked

no DOI — not checked10.1016/j.bbr.2017.01.018_bib0015

no DOI — not checkedBDNF attenuates IL-1beta-induced F-actin remodeling by inhibiting NF-kappaB signaling in hippocampal neurons

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