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Prodrug nanoparticles rationally integrating stroma modification and chemotherapy to treat metastatic pancreatic cancer

https://doi.org/10.1016/j.biomaterials.2021.121176
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38/38 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 38 checked references that resolve
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The role of stromal cancer-associated fibroblasts in pancreatic cancer
resolves10.1053/j.gastro.2012.11.037
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
resolves10.1016/j.biomaterials.2019.119745
Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors
resolves10.1038/ncb3513
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
resolves10.1016/j.canlet.2018.03.031
Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma
resolves10.1073/pnas.1016234107
Malignant cells facilitate lung metastasis by bringing their own soil
resolves10.2353/ajpath.2010.090899
Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis
resolves10.1111/j.1440-1746.2011.07000.x
Dangerous liaisons: Pancreatic stellate cells and pancreatic cancer cells
resolves10.1158/1078-0432.CCR-14-1051
Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer
resolves10.1056/NEJMoa1011923
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
resolves10.1038/s41573-018-0004-1
Turning foes to friends: targeting cancer-associated fibroblasts
resolves10.1053/j.gastro.2017.11.280
Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer
resolves10.1016/j.cell.2014.08.007
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
resolves10.1016/j.jsbmb.2018.12.006
Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells
resolves10.1016/S0006-2952(97)00004-X
Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats comparison with 1α,25-Dihydroxyvitamin d2, calcitriol, and calcipotriol
resolves10.1016/j.ijpharm.2021.120523
A polymeric micellar drug delivery system developed through a design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel
resolves10.1038/natrevmats.2016.14
Analysis of nanoparticle delivery to tumours
resolves10.1016/j.phrs.2019.104398
Irinotecan: 25 years of cancer treatment
resolves10.1186/s12885-018-4845-0
N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer
resolves10.1016/j.biomaterials.2017.08.002
Terminating the criminal collaboration in pancreatic cancer: Nanoparticle-based synergistic therapy for overcoming fibroblast-induced drug resistance
resolves10.1038/ncb3478
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
resolves10.1021/ma300898e
Efficient Synthesis of Amine-Functional Diblock Copolymer Nanoparticles via RAFT Dispersion Polymerization of Benzyl Methacrylate in Alcoholic Media
resolves10.1021/acsnano.5b02017
The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment
resolves10.1021/acsnano.5b07781
Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer
resolves10.1038/ncb3484
Pulling cells out of tumours
resolves10.1002/cyto.b.20157
Granulocyte– and monocyte–platelet adhesion index in coronary and peripheral blood after extracorporeal circulation and reperfusion
resolves10.1016/0140-6736(91)90280-3
Topical calcipotriol treatment in advanced breast cancer
resolves10.1038/natrevmats.2016.75
Bioresponsive materials
resolves10.1002/adma.201606628
Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization
resolves10.1038/nrc.2016.108
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resolves10.1016/j.jconrel.2019.03.015
Threatening cancer with nanoparticle aided combination oncotherapy
resolves10.1016/j.addr.2017.06.003
Nanoformulations for combination or cascade anticancer therapy
resolves10.1016/j.jconrel.2015.10.031
Amphiphilic drugs as surfactants to fabricate excipient-free stable nanodispersions of hydrophobic drugs for cancer chemotherapy
resolves10.1021/acsnano.9b04857
Reshaping Prostate Tumor Microenvironment To Suppress Metastasis <i>via</i> Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem
resolves10.3390/cancers12051347
Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment
resolves10.1186/s12957-019-1574-z
Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma
resolves10.1016/j.canlet.2015.12.027
Matrix control of pancreatic cancer: New insights into fibronectin signaling
resolves10.1002/adma.201603095
Esterase‐Activated Charge‐Reversal Polymer for Fibroblast‐Exempt Cancer Gene Therapy
The 6 references without a DOI — listed, not checked
no DOI — not checkedCancer statistics, 2021
no DOI — not checkedStroma and pancreatic ductal adenocarcinoma: an interaction loop
no DOI — not checkedPancreatic cancer
no DOI — not checkedCancer associated fibroblasts: the architects of stroma remodeling
no DOI — not checkedRole of extracellular matrix assembly in interstitial transport in solid tumors
no DOI — not checkedA new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
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