Reference health
Diacerein: Recent insight into pharmacological activities and molecular pathways
1 of 77 checkable references need attention · checked 2026-07-22
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
10 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
marked retracted — notice via Crossref, record curated by Retraction Watch10.1186/s11658-018-0107-z
RETRACTED ARTICLE: Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice
The 76 checked references that resolve
resolves10.1007/s40266-016-0347-4
Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO
resolves10.1002/1529-0131(200010)43:10<2339::AID-ANR23>3.0.CO;2-P
Efficacy and safety of diacerein in osteoarthritis of the knee: A double-blind, placebo-controlled trial
resolves10.1177/1759720X09359104
Effects of diacerein at the molecular level in the osteoarthritis disease process
resolves10.1016/j.cellsig.2018.12.010
Mechanical exposure and diacerein treatment modulates integrin-FAK-MAPKs mechanotransduction in human osteoarthritis chondrocytes
resolves10.1016/j.cbi.2019.04.008
Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis
resolves10.1016/j.freeradbiomed.2017.11.021
Diacerein alleviates kidney injury through attenuating inflammation and oxidative stress in obese insulin-resistant rats
resolves10.2337/dc17-0374
Efficacy and Safety of Diacerein in Patients With Inadequately Controlled Type 2 Diabetes: A Randomized Controlled Trial
resolves10.1590/2359-3997000000242
Effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus and inadequate glycemic control
resolves10.1111/1756-185X.12741
Diacerein reduces joint damage, pain behavior and inhibits transient receptor potential vanilloid 1, matrix metalloproteinase and glial cells in rat spinal cord
resolves10.1016/j.pbb.2012.06.018
Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice
resolves10.1002/ddr.21232
Combination of Diacerhein and Antiepileptic Drugs After Local Peripheral, and Oral Administration in the Rat Formalin Test
resolves10.1186/s12974-016-0652-1
Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice
resolves10.1016/j.phrs.2014.10.008
Diacerein is a potent and selective inhibitor of palmitoylethanolamide inactivation with analgesic activity in a rat model of acute inflammatory pain
resolves10.1016/j.lfs.2018.07.060
Mechanism mediating the protective effect of diacerein in ischemia-reperfusion-induced testicular injury in rats
resolves10.1016/j.biopha.2017.08.053
Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats
resolves10.1016/j.canlet.2016.12.021
Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy
resolves10.1038/onc.2015.466
Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer
resolves10.2147/CMAR.S171517
<p>Rhein shows potent efficacy against non-small-cell lung cancer through inhibiting the STAT3 pathway</p>
resolves10.1016/j.ejphar.2018.07.031
Hepatoprotective effect of rhein against methotrexate-induced liver toxicity
resolves10.1111/dom.13643
Efficacy of diacerein in reducing liver steatosis and fibrosis in patients with type 2 diabetes and non‐alcoholic fatty liver disease: A randomized, placebo‐controlled trial
resolves10.1152/ajpendo.00332.2010
Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice
resolves10.1111/j.1472-8206.2009.00685.x
Anti‐inflammatory and anti‐peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation
resolves10.1016/j.mehy.2011.09.013
Rhein: A potential biological therapeutic drug for intervertebral disc degeneration
resolves10.1371/journal.pone.0121842
Diacerein Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction
resolves10.1055/s-2007-981469
Combined Therapy of Rhein and Benazepril on the Treatment of Diabetic Nephropathy in <i>db/db</i> Mice
resolves10.1007/s10753-015-0131-3
Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways
resolves10.1097/MJT.0000000000000284
Combination Therapies of Diacerein and Febuxostat Inhibit IL-1β Responses and Improve Clinical Symptoms in Patients With Refractory Gout
resolves10.1155/2016/9507563
Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats
resolves10.1002/(SICI)1099-081X(199712)18:9<769::AID-BDD60>3.0.CO;2-K
Pharmacokinetics and bioavailability of montelukast sodium (MK-0476) in healthy young and elderly volunteers
resolves10.3109/15376516.2012.759306
Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats
resolves10.1038/aps.2012.177
Rhein lysinate increases the median survival time of SAMP10 mice: protective role in the kidney
resolves10.1016/j.freeradbiomed.2010.10.704
Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure
resolves10.1007/s00210-010-0593-7
Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue
resolves10.1038/srep11822
Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-κB activities
resolves10.1055/s-0034-1396241
Anti-Hyperuricemic and Nephroprotective Effects of Rhein in Hyperuricemic Mice
resolves10.2337/dc11-0357
Effect of Diacerein on Insulin Secretion and Metabolic Control in Drug-Naïve Patients With Type 2 Diabetes
resolves10.1007/BF03345796
Improvement of glucose tolerance by rhein with restored early-phase insulin secretion in db/db mice
resolves10.2337/db13-0251
Rhein Protects Pancreatic β-Cells From Dynamin-Related Protein-1–Mediated Mitochondrial Fission and Cell Apoptosis Under Hyperglycemia
resolves10.1210/en.2011-0249
Diacerhein Improves Glucose Tolerance and Insulin Sensitivity in Mice on a High-Fat Diet
resolves10.1016/j.intimp.2008.01.020
Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice
resolves10.1155/2018/4246521
Effect of Diacerein on Metabolic Control and Inflammatory Markers in Patients with Type 2 Diabetes Using Antidiabetic Agents: A Randomized Controlled Trial
resolves10.1084/jem.189.7.1053
In Autoimmune Diabetes the Transition from Benign to Pernicious Insulitis Requires an Islet Cell Response to Tumor Necrosis Factor α
resolves10.1186/s13054-016-1453-8
Retraction Note: Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis
resolves10.1016/j.tem.2015.08.001
The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications
resolves10.1007/s00125-016-3873-z
Multiple benefits of targeting inflammation in the treatment of type 2 diabetes
resolves10.1007/s12020-016-0993-7
Cooling down inflammation in type 2 diabetes: how strong is the evidence for cardiometabolic benefit?
resolves10.1371/journal.pone.0154003
The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction
resolves10.1111/j.1756-185X.2011.01648.x
Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee
resolves10.1042/bj3220671
Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells
resolves10.1016/j.neuropharm.2005.01.001
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies
resolves10.1074/jbc.M106261200
Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance
resolves10.1016/j.pain.2008.06.003
The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors
resolves10.1016/S0014-5793(01)02934-9
Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors
resolves10.1213/01.ane.0000184182.03203.61
The Effects of Diacerhein on Mechanical Allodynia in Inflammatory and Neuropathic Models of Nociception in Mice
resolves10.1111/j.1365-2796.2004.01443.x
Immune regulation of central nervous system functions: from sickness responses to pathological pain
resolves10.1046/j.1365-2710.2001.00355.x
Pharmacology of oral combination analgesics: rational therapy for pain
resolves10.1016/j.febslet.2006.10.061
IL‐1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde?
resolves10.1042/BSR20180515
The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating cadmium-induced testes-toxicity in rat model: implication of PI3K/Akt/Nrf-2 signaling
resolves10.1007/s12011-015-0449-6
The Protective Effects of Melatonin Against Oxidative Stress and Inflammation Induced by Acute Cadmium Exposure in Mice Testis
resolves10.1111/fcp.12285
The role of interleukin‐1b and its antagonist (diacerein) in estradiol benzoate‐induced endometrial hyperplasia and atypia in female rats
resolves10.1093/carcin/bgp127
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
resolves10.1038/sj.onc.1204833
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
resolves10.1007/s12272-014-0423-4
The protection of Rhein lysinate to liver in diabetic mice induced by high-fat diet and streptozotocin
resolves10.1016/j.joca.2009.10.006
Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials
The 10 references without a DOI — listed, not checked
no DOI — not checkedDiacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet
no DOI — not checkedAbdelzaher, W.Y., S.A. Abdel-Gaber, and N.D. Toni, The effect of diacerein versus sulfasalazine on acetic acid-induced ulcerative colitis in rats.
no DOI — not checkedDiacerein downregulates NLRP3/Caspase-1/IL-1β and IL-6/STAT3 pathways of inflammation and apoptosis in a rat model of cadmium testicular toxicity
no DOI — not checkedDiacerein: a potential therapeutic drug for the management of experimental periodontitis in rats
no DOI — not checkedThe possible effects of montelukast against doxorubicin-induced nephrotoxicity in rabbits
no DOI — not checkedMega doses of resveratrol enhance oxidative and nitrosative stress and accelerate inflammations in glycerol-rat model
no DOI — not checkedEffects of rhein on activity of caspase-3 in kidney and cell apoptosis on the progression of renal injury in glomerulosclerosis
no DOI — not checkedDiacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone
no DOI — not checkedInflammatory bowel disease part I: ulcerative colitis–pathophysiology and conventional and alternative treatment options
no DOI — not checkedAtorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
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