Reference health
Xenobiotic metabolism in the fish hepatic cell lines Hepa-E1 and RTH-149, and the gill cell lines RTgill-W1 and G1B: Biomarkers of CYP450 activity and oxidative stress
55/55 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 55 checked references that resolve
resolves10.1002/hep.26160
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells
resolves10.1177/026119298901700203
Use of the Rainbow Trout Hepatoma Cell Line, RTH-149, in a Cytotoxicity Assay
resolves10.1016/0147-6513(91)90072-W
In vitro cytotoxicity studies with the fish hepatoma cell line, PLHC-1 (Poeciliopsis lucida)
resolves10.1016/j.steroids.2006.06.007
Synthesis of unique 17β-estradiol homo-dimers, estrogen receptors binding affinity evaluation and cytocidal activity on breast, intestinal and skin cancer cell lines
resolves10.1111/j.1365-2761.1994.tb00258.x
Development of a cell line from primary cultures of rainbow trout, <i>Oncorhynchus mykiss</i> (Walbaum), gills
resolves10.1016/S1873-0140(05)80005-0
Chapter 2 Use of fish cell lines in the toxicology and ecotoxicology of fish. Piscine cell lines in environmental toxicology
resolves10.1016/j.aquatox.2006.05.010
Cytotoxicity of pharmaceuticals found in aquatic systems: Comparison of PLHC-1 and RTG-2 fish cell lines
resolves10.1016/j.marenvres.2004.03.023
Suppressive effects of benzo[a]pyrene upon fish immune function: Evolutionarily conserved cellular mechanisms of immunotoxicity
resolves10.1016/j.tiv.2005.04.002
Comparison of basal cytotoxicity data between mammalian and fish cell lines: A literature survey
resolves10.1006/abbi.1996.0198
Cytochromes P450 (CYP) in thePoeciliopsis lucidaHepatocellular Carcinoma Cell Line (PLHC-1): Dose- and Time-Dependent Glucocorticoid Potentiation of CYP1A Induction without Induction of CYP3A
resolves10.3390/ijerph120505386
Comparative Cytotoxicity Study of Silver Nanoparticles (AgNPs) in a Variety of Rainbow Trout Cell Lines (RTL-W1, RTH-149, RTG-2) and Primary Hepatocytes
resolves10.1124/dmd.30.5.608
Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen
resolves10.1016/j.tox.2007.11.010
β-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats
resolves10.1016/S0887-2333(01)00053-4
Fish cell lines as versatile tools in ecotoxicology: assessment of cytotoxicity, cytochrome P4501A induction potential and estrogenic activity of chemicals and environmental samples
resolves10.1023/A:1025457831923
Effects of dimethoate and beta-naphthoflavone on selected biomarkers of Poecilia reticulata
resolves10.1007/BF01404816
Three decades of fish cell culture: A current listing of cell lines derived from fishes
resolves10.2174/157016461204160119161034
Identification of Fish Cell Lines Using 2-D Electrophoresis Based Protein Expression Signatures
resolves10.1016/S0045-6535(97)10248-X
A fish hepatoma cell line (PLHC-1) as a tool to study cytotoxicity and CYP1A induction properties of cellulose and wood chip extracts
resolves10.1016/0003-2697(88)90554-4
A spectrophotometric method for determination of catalase activity in small tissue samples
resolves10.1016/j.tiv.2012.01.001
Assessment of RTG-W1, RTL-W1, and PLHC-1 fish cell lines for genotoxicity testing of environmental pollutants by means of a Fpg-modified comet assay
resolves10.1002/mrd.20603
Tamoxifen induces masculinization of genetic females and regulates P450 aromatase and müllerian inhibiting substance mRNA expression in Japanese flounder (<i>Paralichthys olivaceus</i>)
resolves10.1080/03602530600569919
The Role of Flavin-Containing Monooxygenase (FMO) in the Metabolism of Tamoxifen and Other Tertiary Amines
resolves10.1016/j.tox.2011.01.020
Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats
resolves10.1007/s10695-010-9411-x
Development, characterization, conservation and storage of fish cell lines: a review
resolves10.1007/BF02618871
Fish cell lines: Establishment and characterization of nine cell lines from salmonids
resolves10.1021/es902583q
Site-Specific Profiles of Estrogenic Activity in Agricultural Areas of California’s Inland Waters
resolves10.1016/j.taap.2008.11.017
Mechanisms of fenthion activation in rainbow trout (Oncorhynchus mykiss) acclimated to hypersaline environments
resolves10.1371/journal.pone.0154208
Biochemical Mechanisms for Geographical Adaptations to Novel Toxin Exposures in Butterflyfish
resolves10.1016/j.tox.2006.10.027
Opercular epithelial cells: A simple approach for in vitro studies of cellular responses in fish
resolves10.1016/0041-008X(85)90262-5
Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient
resolves10.1124/dmd.113.053777
Tissue-Specific Metabolism of Benzo[a]pyrene in Rainbow Trout (Oncorhynchus mykiss): A Comparison between the Liver and Immune Organs
resolves10.1016/j.aquatox.2006.01.017
In vitro–in vivo extrapolation of quantitative hepatic biotransformation data for fish
resolves10.1139/f81-125
Establishment of Walking Catfish (<i>Clarias batrachus</i>) Cell Lines and Development of a Channel Catfish (<i>Ictalurus punctatus</i>) Virus Vaccine
resolves10.1016/j.etap.2004.11.002
Protein carbonyls: novel biomarkers of exposure to oxidative stress-inducing pesticides in freshwater fish Channa punctata (Bloch)
resolves10.1016/S0166-445X(98)00133-7
Oxidative stress in liver of brown bullhead and channel catfish following exposure to tert-butyl hydroperoxide
resolves10.1016/S0147-6513(03)00009-5
Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch
resolves10.1016/j.aquatox.2008.08.005
Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
resolves10.1007/s001289900558
Impact of Deltamethrin on Serum Calcium and Inorganic Phosphate of Freshwater Catfish, Heteropneustes fossilis
resolves10.1007/s00706-016-1713-y
NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1
resolves10.1016/j.chemosphere.2017.05.151
Application of fish cell lines for evaluating the chromium induced cytotoxicity, genotoxicity and oxidative stress
resolves10.1016/j.chemosphere.2004.02.023
Juvenile sea bass biotransformation, genotoxic and endocrine responses to β-naphthoflavone, 4-nonylphenol and 17β-estradiol individual and combined exposures
resolves10.1007/s10565-008-9116-4
Assessment of metabolic capabilities of PLHC-1 and RTL-W1 fish liver cell lines
resolves10.1016/j.ecoenv.2007.03.009
β-Naphthoflavone and benzo(a)pyrene treatment affect liver intermediary metabolism and plasma cortisol levels in rainbow trout Oncorhynchus mykiss
resolves10.1016/0300-483X(93)90001-9
Relationship between the critical level of oxidative stresses and the glutathione peroxidase activity
resolves10.1016/S0024-3205(97)00366-4
Handling stress does not affect the expression of hepatic heat shock protein 70 and conjugation enzymes in rainbow trout treated with β-naphthoflavone
resolves10.1016/S0021-9258(20)81942-5
Metabolism of alpha-naphthoflavone and beta-naphthoflavone by rat liver microsomes and highly purified reconstituted cytochrome P-450 systems.
resolves10.1016/0006-2952(93)90372-4
Induction of CYP2B1 and 3A1, and associated monooxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice
resolves10.1080/10408440903036056
The European Union’s REACH regulation: a review of its history and requirements
resolves10.1677/joe.0.1570063
beta-Naphthoflavone abolishes interrenal sensitivity to ACTH stimulation in rainbow trout
resolves10.1016/j.jchromb.2008.01.018
Simultaneous determination of benzo[a]pyrene and eight of its metabolites in Fundulus heteroclitus bile using ultra-performance liquid chromatography with mass spectrometry
The 6 references without a DOI — listed, not checked
no DOI — not checkedIntroduction to the 3Rs (refinement, reduction and replacement)
no DOI — not checkedImproving the in vitro ethoxyresorufin-O-deethylase (EROD) assay with RTL-W1 by metabolic normalization and use of beta-naphthoflavone as the reference substance
no DOI — not checkedDifferential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants
no DOI — not checkedFish cell lines as a tool in aquatic toxicology
no DOI — not checkedEndpoints for in vitro toxicity testing with fish cells
no DOI — not checkedA review: oxidative stress in fish induced by pesticides
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