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Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

https://doi.org/10.1016/j.ccr.2012.05.019

38/38 checkable references clean · checked 2026-07-25

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

The 38 checked references that resolve

resolves10.1038/318533a0

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

resolves10.1038/ncb1225

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

resolves10.1038/nature07449

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

resolves10.1038/nrm2184

The multifunctional nucleolus

resolves10.1016/j.molcel.2010.09.024

The Nucleolus under Stress

resolves10.1126/scisignal.2001754

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

resolves10.1002/jcb.21895

Crosstalk between c‐Myc and ribosome in ribosomal biogenesis and cancer

resolves10.1016/j.semcancer.2006.07.014

The c-Myc target gene network

resolves10.1038/onc.2010.189

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

resolves10.1111/j.1365-2559.2008.03168.x

What the nucleolus says to a tumour pathologist

resolves10.1038/ng1651

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

resolves10.1158/0008-5472.CAN-10-1728

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

resolves10.1101/gad.13.20.2658

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

resolves10.1038/ncb1858

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

resolves10.1038/ncb1224

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

resolves10.1038/ncb1223

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

resolves10.1128/MCB.23.23.8862-8877.2003

mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†

resolves10.1074/jbc.273.2.1257

Affinity Purification of Mammalian RNA Polymerase I

resolves10.1073/pnas.96.23.13180

c-Myc enhances protein synthesis and cell size during B lymphocyte development

resolves10.1126/science.1070850

Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

resolves10.1016/0378-1119(93)90065-B

Multistep evolution of B-cell-derived tumors in humans and rodents

resolves10.1007/s001090050196

Transcription by RNA polymerases I and III: a potential link between cell growth, protein synthesis and the retinoblastoma protein

resolves10.1016/S1535-6108(03)00134-X

Regulation of HDM2 activity by the ribosomal protein L11

resolves10.1016/j.ccr.2010.08.007

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

resolves10.1146/annurev.cellbio.24.110707.175259

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

resolves10.1038/sj.emboj.7600335

MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation

resolves10.1093/nar/gkq1205

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

resolves10.1038/nrc1015

Does the ribosome translate cancer?

resolves10.1136/jcp.2009.070961

Pharmacological activation of the p53 pathway in haematological malignancies

resolves10.1083/jcb.200805146

UBF levels determine the number of active ribosomal RNA genes in mammals

resolves10.1038/79542

Genetic analysis of chemoresistance in primary murine lymphomas

resolves10.1038/onc.2009.21

c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells

resolves10.1016/S1097-2765(01)00384-7

An Immediate Response of Ribosomal Transcription to Growth Factor Stimulation in Mammals Is Mediated by ERK Phosphorylation of UBF

resolves10.1038/nrc2819

MYC as a regulator of ribosome biogenesis and protein synthesis

resolves10.1038/nrm1551

RNA polymerases I and III, growth control and cancer

resolves10.1016/j.molcel.2005.05.023

Genetic Inactivation of the Transcription Factor TIF-IA Leads to Nucleolar Disruption, Cell Cycle Arrest, and p53-Mediated Apoptosis

resolves10.1128/MCB.23.23.8902-8912.2003

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

resolves10.1101/gad.1771409

Mouse models of human AML accurately predict chemotherapy response

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