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PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion

https://doi.org/10.1016/j.celrep.2017.05.092
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37/37 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 37 checked references that resolve
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scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
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Identification of Novel Ras-Cooperating Oncogenes in <i>Drosophila melanogaster</i>: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis
resolves10.1074/jbc.M110.131714
Disruption of Lysosome Function Promotes Tumor Growth and Metastasis in Drosophila
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Drugging the undruggable RAS: Mission Possible?
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Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
resolves10.1128/MCB.00741-09
Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates γ-H2AX
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Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting
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Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase Signaling
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Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics
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A Landscape of Driver Mutations in Melanoma
resolves10.1074/jbc.M111.333708
PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase
resolves10.1093/emboj/cdf306
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
resolves10.1016/j.cub.2006.04.042
Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila
resolves10.1016/j.devcel.2009.01.002
Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila
resolves10.1074/jbc.M608155200
Protein Phosphatase 6 Down-regulates TAK1 Kinase Activation in the IL-1 Signaling Pathway
resolves10.1038/ng.2359
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
resolves10.1016/j.devcel.2015.02.012
Systemic Organ Wasting Induced by Localized Expression of the Secreted Insulin/IGF Antagonist ImpL2
resolves10.1038/sj.cdd.4401790
JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila
resolves10.1016/j.ydbio.2013.05.013
dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila
resolves10.1038/cdd.2013.154
Bendless modulates JNK-mediated cell death and migration in Drosophila
resolves10.1038/cddis.2015.111
Wallenda regulates JNK-mediated cell death in Drosophila
resolves10.1073/pnas.1009376107
A tumor-suppressing mechanism in <i>Drosophila</i> involving cell competition and the Hippo pathway
resolves10.1016/S0960-9822(02)00954-5
Evolution of TNF Signaling Mechanisms
resolves10.1126/science.1088474
A Genetic Screen in <i>Drosophila</i> for Metastatic Behavior
resolves10.1146/annurev-genet-110711-155414
Dissecting Social Cell Biology and Tumors Using <i>Drosophila</i> Genetics
resolves10.1101/gr.169101
A Systematic Analysis of Human Disease-Associated Gene Sequences In <i>Drosophila melanogaster</i>
resolves10.1002/dvdy.22771
<i>Drosophila</i> cancer models
resolves10.1016/j.trecan.2015.10.001
Targeting RAS -mutant Cancers: Is ERK the Key?
resolves10.1038/nrd4281
Targeting RAS–ERK signalling in cancer: promises and challenges
resolves10.1073/pnas.0611666104
Basement membrane remodeling is essential for <i>Drosophila</i> disc eversion and tumor invasion
resolves10.4161/cc.6.11.4276
Protein Phosphatase PP6 N Terminal Domain Restricts G<sub>1</sub>to S Phase Progression in Human Cancer Cells
resolves10.1016/j.ccr.2014.02.017
Dragging Ras Back in the Ring
resolves10.1038/sj.emboj.7601401
JNK‐ and Fos‐regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila
resolves10.1016/j.devcel.2005.11.007
Csk-Deficient Boundary Cells Are Eliminated from Normal Drosophila Epithelia by Exclusion, Migration, and Apoptosis
resolves10.1126/science.1235122
Cancer Genome Landscapes
resolves10.1016/j.devcel.2007.07.012
Tumor Suppressor CYLD Regulates JNK-Induced Cell Death in Drosophila
resolves10.1083/jcb.201008106
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
The 2 references without a DOI — listed, not checked
no DOI — not checkedIn Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling
no DOI — not checkedAn in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery
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