Reference health
Zebrafish models in cardiac development and congenital heart birth defects
176/176 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 176 checked references that resolve
resolves10.1242/dev.031492
Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo
resolves10.1371/journal.pbio.0050053
Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes
resolves10.1242/dev.01970
Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development
resolves10.1242/dev.00838
Mutation of<i>weak atrium/atrial myosin heavy chain</i>disrupts atrial function and influences ventricular morphogenesis in zebrafish
resolves10.1016/j.ydbio.2009.04.011
Shaping the zebrafish heart: From left–right axis specification to epithelial tissue morphogenesis
resolves10.1371/journal.pbio.0020129
Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish
resolves10.1038/nature03000
Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
resolves10.1101/gad.1448306
Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart
resolves10.1161/CIRCULATIONAHA.106.637819
Targeted Mutation Reveals Essential Functions of the Homeodomain Transcription Factor
<i>Shox2</i>
in Sinoatrial and Pacemaking Development
resolves10.1242/dev.123.1.293
Mutations affecting the cardiovascular system and other internal organs in zebrafish
resolves10.1371/journal.pbio.0060109
Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System
resolves10.1101/gad.1629408
Foxn4 directly regulates <i>tbx2b</i> expression and atrioventricular canal formation
resolves10.1002/dvdy.10487
T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
resolves10.1073/pnas.0909432107
Cardiac conduction is required to preserve cardiac chamber morphology
resolves10.1016/j.tcm.2004.09.002
Architectural Plan for the Heart: Early Patterning and Delineation of the Chambers and the Nodes
resolves10.1016/j.cell.2004.08.010
A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis
resolves10.1161/CIRCRESAHA.111.261172
Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation
resolves10.1242/dev.030924
Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart
resolves10.1101/gad.1467706
FGF signaling delineates the cardiac progenitor field in the simple chordate,
<i>Ciona intestinalis</i>
resolves10.1101/gad.177758.111
Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization
resolves10.2144/000113078
A New Method for Detection and Quantification of Heartbeat Parameters in Drosophila, Zebrafish, and Embryonic Mouse Hearts
resolves10.1016/S1084952102001040
Cardiac development in zebrafish: coordination of form and function
resolves10.1242/dev.129.19.4635
The<i>heartstrings</i>mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome
resolves10.1242/dev.052225
Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function
resolves10.1242/dmm.000513
Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke
resolves10.1016/j.devcel.2006.12.011
Notch Signaling Is Essential for Ventricular Chamber Development
resolves10.1038/378390a0
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
resolves10.1016/j.diff.2012.05.002
The arterial and cardiac epicardium in development, disease and repair
resolves10.1038/ng815
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy
resolves10.1073/pnas.95.12.6815
Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers
resolves10.1016/j.ydbio.2005.11.042
Solving an enigma: Arterial pole development in the zebrafish heart
resolves10.1126/science.1100035
Optical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy
resolves10.1242/dev.022426
Selective plane illumination microscopy techniques in developmental biology
resolves10.1016/j.ydbio.2007.09.018
Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes
resolves10.1016/S0960-9822(01)00458-4
Positional cloning of heart and soul reveals multiple roles for PKCλ in zebrafish organogenesis
resolves10.1242/dev.02857
Endocardium is necessary for cardiomyocyte movement during heart tube assembly
resolves10.1038/nature01282
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
resolves10.1002/1097-0185(20001001)260:2<148::AID-AR50>3.0.CO;2-X
Structure and function of the developing zebrafish heart
resolves10.1038/nm.2037
Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy
resolves10.1242/dev.00947
Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart
resolves10.1016/j.ydbio.2007.03.526
A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos
resolves10.1073/pnas.0702240104
Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5
resolves10.1016/j.cub.2004.04.006
Zebrafish Mosaic Eyes Is a Novel FERM Protein Required for Retinal Lamination and Retinal Pigmented Epithelial Tight Junction Formation
resolves10.1038/nature08899
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
resolves10.1242/jcs.084772
The myosin-interacting protein SMYD1 is essential for sarcomere organization
resolves10.1016/j.diff.2012.04.006
Normal and abnormal development of the cardiac conduction system; implications for conduction and rhythm disorders in the child and adult
resolves10.1038/nature08804
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
resolves10.1016/j.devcel.2011.01.010
Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration
resolves10.1101/gad.892301
<i>casanova</i> encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish
resolves10.1101/gad.14.10.1279
The zebrafish <i>bonnie and clyde</i> gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors
resolves10.1038/35018092
A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development
resolves10.1126/science.1167449
The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
resolves10.1038/nm.1918
Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway
resolves10.1242/dev.02777
Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
resolves10.1242/dev.067041
<i>tcf21+</i> epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration
resolves10.1073/pnas.0915016107
PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts
resolves10.1161/CIRCULATIONAHA.107.689984
Laminin-α4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells
resolves10.1038/290595a0
Localization of pacemaking activity in early embryonic heart monitored using voltage-sensitive dye
resolves10.1242/dev.120.12.3361
Cardiovascular development in the zebrafish: II. Endocardial progenitors are sequestered within the heart field
resolves10.1161/CIRCRESAHA.111.247635
MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting
<i>Has2</i>
and Extracellular Hyaluronic Acid Production
resolves10.1161/CIRCRESAHA.110.218693
Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular Myocardium
resolves10.1016/j.cell.2006.08.052
A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration
resolves10.1161/CIRCRESAHA.110.217950
Tbx5 and Bmp Signaling Are Essential for Proepicardium Specification in Zebrafish
resolves10.1002/dvdy.10264
Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart function
resolves10.1016/j.devcel.2011.06.007
Forward and Reverse Genetic Approaches for the Analysis of Vertebrate Development in the Zebrafish
resolves10.1038/ng.1078
CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium
resolves10.1038/nbt1398
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
resolves10.1242/dev.043588
The BMP pathway acts to directly regulate <i>Tbx20</i> in the developing heart
resolves10.1016/j.ydbio.2008.06.033
Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart
resolves10.1016/j.ydbio.2009.02.010
Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality
resolves10.1242/dev.126.6.1235
<i>oko meduzy</i> mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet
resolves10.1242/dev.02469
<i>santa</i>and<i>valentine</i>pattern concentric growth of cardiac myocardium in the zebrafish
resolves10.1016/j.cub.2003.11.055
heart of glass Regulates the Concentric Growth of the Heart in Zebrafish
resolves10.1242/dev.02279
Notch1b and neuregulin are required for specification of central cardiac conduction tissue
resolves10.1161/CIRCRESAHA.108.186676
A Single Serine in the Carboxyl Terminus of Cardiac Essential Myosin Light Chain-1 Controls Cardiomyocyte Contractility In Vivo
resolves10.1128/MCB.05269-11
PINCH Proteins Regulate Cardiac Contractility by Modulating Integrin-Linked Kinase-Protein Kinase B Signaling
resolves10.1161/CIRCULATIONAHA.108.821082
Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including
<i>GINS3</i>
, as Regulators of Myocardial Repolarization
resolves10.1161/01.CIR.0000061912.88753.87
Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish
resolves10.1016/j.cub.2008.10.061
The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish
resolves10.1016/j.cub.2006.03.058
oko meduzy and Related crumbs Genes Are Determinants of Apical Cell Features in the Vertebrate Embryo
resolves10.1126/science.1132292
Gene Regulatory Networks in the Evolution and Development of the Heart
resolves10.1038/nature09249
Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca2+ channel
resolves10.1161/CIRCULATIONAHA.106.183056
Genetic Basis for Congenital Heart Defects: Current Knowledge
resolves10.1016/S0091-679X(04)76026-4
Discovery and Use of Small Molecules for Probing Biological Processes in Zebrafish
resolves10.1016/j.ydbio.2007.08.018
Redundancy and evolution of GATA factor requirements in development of the myocardium
resolves10.1016/S0960-9822(01)00482-1
Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul
resolves10.1002/dvdy.22154
Chondroitin sulfate expression is required for cardiac atrioventricular canal formation
resolves10.1242/dev.067454
Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish
resolves10.1002/dvdy.22526
Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish
resolves10.1038/nbt963
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation
resolves10.1101/gad.13.22.2983
Gata5 is required for the development of the heart and endoderm in zebrafish
resolves10.1038/ng0398-271
The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
resolves10.1371/journal.pone.0000398
Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling
resolves10.1006/dbio.2001.0259
Bmp2b and Oep Promote Early Myocardial Differentiation through Their Regulation of gata5
resolves10.1242/dev.02182
Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis
resolves10.1161/CIRCRESAHA.107.165241
Asymmetric Involution of the Myocardial Field Drives Heart Tube Formation in Zebrafish
resolves10.1242/dev.125.13.2381
<i>Fgf8</i> is mutated in zebrafish <i>acerebellar</i> (<i>ace</i>) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisy
resolves10.1016/S0092-8674(02)01112-1
Reptin and Pontin Antagonistically Regulate Heart Growth in Zebrafish Embryos
resolves10.1016/S1534-5807(01)00023-5
Growth and Function of the Embryonic Heart Depend upon the Cardiac-Specific L-Type Calcium Channel α1 Subunit
resolves10.1242/dev.02607
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors
resolves10.1073/pnas.162301699
Neuregulin-1 promotes formation of the murine cardiac conduction system
resolves10.1242/dev.123.1.285
Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo
resolves10.1016/S0168-9525(02)02766-X
A window to the heart: can zebrafish mutants help us understand heart disease in humans?
resolves10.1152/ajpheart.00870.2002
Functional and morphological evidence for a ventricular conduction system in zebrafish and<i>Xenopus</i>hearts
resolves10.1242/dev.119.1.31
Cardiovascular development in the zebrafish I. Myocardial fate map and heart tube formation
resolves10.1016/j.devcel.2007.05.012
Vessel and Blood Specification Override Cardiac Potential in Anterior Mesoderm
resolves10.1172/JCI59472
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function
resolves10.1016/j.devcel.2007.01.012
The G Protein-Coupled Receptor Agtrl1b Regulates Early Development of Myocardial Progenitors
resolves10.1016/j.devcel.2007.11.015
Rotation and Asymmetric Development of the Zebrafish Heart Requires Directed Migration of Cardiac Progenitor Cells
resolves10.1242/dev.010694
High-speed imaging of developing heart valves reveals interplay of morphogenesis and function
resolves10.1161/CIRCULATIONAHA.108.843714
Dominant-Negative
<i>ALK2</i>
Allele Associates With Congenital Heart Defects
resolves10.1242/dev.065375
Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development
resolves10.1038/nature10188
De novo cardiomyocytes from within the activated adult heart after injury
resolves10.1038/ng875
Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
resolves10.1073/pnas.0708451105
Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing
<i>Nkx2.5</i>
expression
resolves10.1016/j.ydbio.2006.12.048
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
resolves10.1016/j.cell.2004.09.011
CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism
resolves10.1016/S0012-1606(03)00037-X
Cardiac neural crest contributes to cardiomyogenesis in zebrafish
resolves10.1016/j.ydbio.2008.07.037
Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number
resolves10.1371/journal.pone.0004249
Nkx2.7 and Nkx2.5 Function Redundantly and Are Required for Cardiac Morphogenesis of Zebrafish Embryos
resolves10.1038/ncomms1187
Chromatin remodelling complex dosage modulates transcription factor function in heart development
resolves10.1242/dev.024083
Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential
resolves10.1016/S1534-5807(04)00063-2
Fibronectin Regulates Epithelial Organization during Myocardial Migration in Zebrafish
resolves10.1242/dev.064261
The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis
resolves10.1101/gad.276304
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
resolves10.1101/gad.174037.111
A versatile gene trap to visualize and interrogate the function of the vertebrate proteome
resolves10.1073/pnas.0702859104
Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells
resolves10.1002/bdra.20804
Wnt signaling regulates atrioventricular canal formation upstream of <i>BMP</i> and <i>Tbx2</i>
resolves10.1371/journal.pbio.1000246
Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart
resolves10.1038/ng.594
Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes
resolves10.1126/science.293.5535.1670
UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish
resolves10.1016/j.devcel.2008.09.009
Hoxb5b Acts Downstream of Retinoic Acid Signaling in the Forelimb Field to Restrict Heart Field Potential in Zebrafish
resolves10.1038/ng883
nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina
resolves10.1016/j.ajhg.2010.10.002
Mutations in NEXN, a Z-Disc Gene, Are Associated with Hypertrophic Cardiomyopathy
resolves10.1038/ng816
Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin
resolves10.1006/scdb.1998.0278
Patterning during organogenesis: genetic analysis of cardiac chamber formation
resolves10.1242/dev.127.12.2573
The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development
resolves10.1016/j.ydbio.2011.12.006
Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease
resolves10.1006/dbio.1999.9406
Restricted Expression of Cardiac Myosin Genes Reveals Regulated Aspects of Heart Tube Assembly in Zebrafish
resolves10.1006/dbio.2000.9927
Expression of Chick Tbx-2, Tbx-3, and Tbx-5 Genes during Early Heart Development: Evidence for BMP2 Induction of Tbx2
resolves10.1016/j.devcel.2007.01.011
Apelin and Its Receptor Control Heart Field Formation during Zebrafish Gastrulation
resolves10.1038/nature10094
Latent TGF-β binding protein 3 identifies a second heart field in zebrafish
resolves10.1038/nature07060
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
resolves10.1126/science.287.5459.1820
<i>gridlock</i>
, an HLH Gene Required for Assembly of the Aorta in Zebrafish
The 1 reference without a DOI — listed, not checked
no DOI — not checkedThe phylogenetic and ontogenetic development of the mammalian heart: some theoretical considerations
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