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Medium optimization for the production of the secondary metabolite squalestatin S1 by a Phoma sp. combining orthogonal design and response surface methodology
19/19 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 19 checked references that resolve
resolves10.7164/antibiotics.47.740
The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. V. Minor metabolites.
resolves10.1007/s002530051177
Influence of water activity and temperature on in vitro growth of surface cultures of a Phoma sp. and production of the pharmaceutical metabolites, squalestatins S1 and S2
resolves10.7164/antibiotics.45.639
The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
resolves10.1271/bbb1961.40.191
Regulation of N-acetylkanamycin amidohydrolase in the idiophase in kanamycin fermentation.
resolves10.1016/j.enzmictec.2003.12.004
Regulation of synthesis of the pectolytic enzymes of Aspergillus niger
resolves10.1007/BF00254638
Optimization of a medium for the production of 1,2-epoxytetradecane by Nocardia corallina B-276
resolves10.1007/BF00169424
Application of a statistical design to the optimization of culture medium for recombinant interferon-gamma production by Chinese hamster ovary cells
resolves10.1016/S0168-1656(99)00182-0
Optimization of gibberellic acid production by immobilized Gibberella fujikuroi mycelium in fluidized bioreactors
resolves10.1016/S0032-9592(02)00224-8
Optimization of submerged culture conditions for mycelial growth and exo-biopolymer production by Paecilomyces tenuipes C240
resolves10.1002/bit.260400812
Maximization of lipid production by <i>Rhodotorula gracilis</i> CFR‐1 using response surface methodology
resolves10.1073/pnas.90.1.80
Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.
resolves10.1016/S0032-9592(97)00031-9
Medium improvement by orthogonal array designs for cholesterol oxidase production by Rhodococcus equi No. 23
resolves10.1007/s002530100598
Efficient pyruvate production by a multi-vitamin auxotroph of Torulopsis glabrata : key role and optimization of vitamin levels
resolves10.1016/S0032-9592(02)00330-8
The influence of medium design on lovastatin production and pellet formation with a high-producing mutant of Aspergillus terreus in submerged cultures
resolves10.1016/S0141-0229(03)00159-5
Marked enhancement of epoxide hydrolase production from Trichosporon loubierii ECU1040 by substrate induction and fed-batch fermentation
resolves10.1007/BF01570022
Effects of medium sterilization on the production of zaragozic acids by the fungusLeptodontidium elatius
resolves10.1021/np50101a009
Zaragozic Acids D and D<sub>2</sub>: Potent Inhibitors of Squalene Synthase and of Ras Farnesyl-Protein Transferase
resolves10.1016/S0040-4020(01)88327-7
The isolation and structure elucidation of zaragozic acid C, a novel potent squalene synthase inhibitor.
resolves10.1046/j.1365-2672.1999.00931.x
Influence of water activity and nutrients on growth and production of squalestatin S1 by a Phoma sp.
The 3 references without a DOI — listed, not checked
no DOI — not checkedPhysiological regulation of secondary metabolism
no DOI — not checkedMicrobial secondary metabolism: a new theoretical frontier for academia, a new opportunity for industry
no DOI — not checkedA systematic growth fro optimization of media and growth conditions
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