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Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II

https://doi.org/10.1016/j.freeradbiomed.2018.11.033
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38/38 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 38 checked references that resolve
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Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage
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Targeting hexokinase <scp>II</scp> to mitochondria to modulate energy metabolism and reduce ischaemia‐reperfusion injury in heart
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Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
resolves10.1006/abbi.1996.0186
Functional Organization of Mammalian Hexokinases: Both N- and C-Terminal Halves of the Rat Type II Isozyme Possess Catalytic Sites
resolves10.2174/0929867033457269
Hexokinase II: The Integration of Energy Metabolism and Control of Apoptosis
resolves10.18388/abp.2003_3693
The function of complexes between the outer mitochondrial membrane pore (VDAC) and the adenine nucleotide translocase in regulation of energy metabolism and apoptosis.
resolves10.1038/nrm2952
Mitochondria and cell death: outer membrane permeabilization and beyond
resolves10.1161/JAHA.112.005645
Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion
resolves10.1523/JNEUROSCI.2040-10.2010
The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic<sup>13</sup>C Nuclear Magnetic Resonance Spectroscopy
resolves10.1038/cddis.2017.43
Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1
resolves10.1016/j.bbadis.2017.06.011
Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol
resolves10.1152/physrev.00011.2017
Neuronal Cell Death
resolves10.1111/bph.12416
Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities
resolves10.1074/jbc.M313329200
Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition
resolves10.1126/scisignal.2000902
Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1–Dependent Cell Death (Parthanatos)
resolves10.1073/pnas.0606528103
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
resolves10.1038/cddis.2013.518
Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress
resolves10.1111/fcp.12232
Research review on the pharmacological effects of astragaloside<scp>IV</scp>
resolves10.1016/j.neuint.2009.04.012
Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture
resolves10.1248/cpb.c13-00556
Astragaloside IV Inhibits Doxorubicin-Induced Cardiomyocyte Apoptosis Mediated by Mitochondrial Apoptotic Pathway &lt;i&gt;via&lt;/i&gt; Activating the PI3K/Akt Pathway
resolves10.1155/2017/8424326
Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms
resolves10.1155/2012/935738
Astragaloside IV Inhibits Oxidative Stress-Induced Mitochondrial Permeability Transition Pore Opening by Inactivating GSK-3<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>via Nitric Oxide in H9c2 Cardiac Cells
resolves10.3389/fphys.2018.00015
Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice
resolves10.1161/01.STR.20.1.84
Reversible middle cerebral artery occlusion without craniectomy in rats.
resolves10.15252/embj.201488327
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
resolves10.1016/j.taap.2015.03.010
Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK
resolves10.1016/j.taap.2017.12.019
Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice
resolves10.3892/ijmm.2015.2345
Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells
resolves10.1074/jbc.M113.482026
Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes
resolves10.1016/j.bbadis.2017.03.006
Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro
resolves10.1016/j.semcdb.2017.04.001
The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation
resolves10.1126/science.1216338
Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1
resolves10.1126/science.1072221
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
resolves10.1113/jphysiol.2007.145409
Ca<sup>2+</sup>‐dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP‐ribose) polymerase‐1 activation during glutamate excitotoxicity
The 2 references without a DOI — listed, not checked
no DOI — not checkedMouse model of intraluminal MCAO: cerebral infarct evaluation by cresyl violet staining
no DOI — not checkedPreparation of dissociated mouse cortical neuron cultures
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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