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B7 family checkpoint regulators in immune regulation and disease
113/113 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 113 checked references that resolve
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T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds
resolves10.1016/1074-7613(95)90161-2
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
resolves10.4049/jimmunol.171.7.3348
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells
resolves10.1056/NEJMoa063842
Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412
resolves10.1111/j.1476-5381.2010.00922.x
Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4
<sup>+</sup>
effector memory T‐cells
resolves10.1182/blood-2010-12-319780
Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412
resolves10.1016/j.jaci.2008.07.049
Toward experimental assessment of receptor occupancy: TGN1412 revisited
resolves10.1016/S1074-7613(00)80117-X
B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα
resolves10.1016/j.immuni.2011.03.023
ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6
resolves10.1038/16717
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
resolves10.4049/jimmunol.165.9.5035
Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells
resolves10.1016/S1074-7613(00)00011-X
The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses
resolves10.1038/ni1261
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
resolves10.1038/35051100
ICOS co-stimulatory receptor is essential for T-cell activation and function
resolves10.1002/eji.201040416
Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system
resolves10.1158/0008-5472.CAN-11-1138
The ICOS/ICOSL Pathway Is Required for Optimal Antitumor Responses Mediated by Anti–CTLA-4 Therapy
resolves10.1016/1074-7613(94)90071-X
CTLA-4 can function as a negative regulator of T cell activation
resolves10.1126/science.1202947
Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
resolves10.1126/science.270.5238.985
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in
<i>Ctla-4</i>
resolves10.1172/JCI117982
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.
resolves10.1172/JCI118146
Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.
resolves10.1016/j.autrev.2013.01.001
Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis
resolves10.1007/s10875-011-9527-5
CTLA-4-Ig Therapy Diminishes the Frequency but Enhances the Function of Treg Cells in Patients with Rheumatoid Arthritis
resolves10.1016/S0140-6736(11)60886-6
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
resolves10.1016/j.transproceed.2010.08.037
High Levels of IDO-Expressing CD16+ Peripheral Cells, and Tregs in Graft Biopsies From Kidney Transplant Recipients Under Belatacept Treatment
resolves10.1053/j.seminoncol.2010.09.010
Clinical Development of the Anti–CTLA-4 Antibody Tremelimumab
resolves10.1073/pnas.0806075105
CTLA-4 blockade increases IFNγ-producing CD4
<sup>+</sup>
ICOS
<sup>hi</sup>
cells to shift the ratio of effector to regulatory T cells in cancer patients
resolves10.1073/pnas.1110814108
Integrated NY-ESO-1 antibody and CD8
<sup>+</sup>
T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
resolves10.1158/1078-0432.CCR-06-2318
A Pilot Trial of CTLA-4 Blockade with Human Anti-CTLA-4 in Patients with Hormone-Refractory Prostate Cancer
resolves10.4049/jimmunol.173.8.4919
Blocking Programmed Death-1 Ligand-PD-1 Interactions by Local Gene Therapy Results in Enhancement of Antitumor Effect of Secondary Lymphoid Tissue Chemokine
resolves10.1128/MCB.25.21.9543-9553.2005
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
resolves10.1016/j.immuni.2007.05.016
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
resolves10.1016/S1074-7613(00)80089-8
Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor
resolves10.1126/science.291.5502.319
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
resolves10.1084/jem.20022125
The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice
resolves10.1084/jem.20022119
Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis
resolves10.1093/intimm/dxp072
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells
resolves10.1158/1078-0432.CCR-07-4079
Phase I Safety and Pharmacokinetic Study of CT-011, a Humanized Antibody Interacting with PD-1, in Patients with Advanced Hematologic Malignancies
resolves10.1200/JCO.2009.26.7609
Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
resolves10.1056/NEJMoa1200690
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
resolves10.1111/j.1600-065X.2011.01064.x
The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation
resolves10.1002/art.23674
Development of autoimmune hepatitis–like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator
resolves10.4049/jimmunol.175.9.5774
Differential Effects of B and T Lymphocyte Attenuator and Programmed Death-1 on Acceptance of Partially versus Fully MHC-Mismatched Cardiac Allografts
resolves10.4049/jimmunol.1102807
B and T Lymphocyte Attenuator Mediates Inhibition of Tumor-Reactive CD8+ T Cells in Patients After Allogeneic Stem Cell Transplantation
resolves10.1111/j.1365-2567.2007.02723.x
Soluble CD276 (B7‐H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum
resolves10.1007/s12031-008-9133-z
Circulating B7-H3(CD276) Elevations in Cerebrospinal Fluid and Plasma of Children with Bacterial Meningitis
resolves10.4049/jimmunol.0904020
B7-H3 Augments the Inflammatory Response and Is Associated with Human Sepsis
resolves10.1073/pnas.0802423105
Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses
resolves10.1002/eji.200839028
B7‐H3 is a potent inhibitor of human T‐cell activation: No evidence for B7‐H3 and TREML2 interaction
resolves10.1158/0008-5472.CAN-08-4517
MicroRNA miR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors
resolves10.1007/s11060-009-0038-7
Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastoma
resolves10.1007/s11060-012-1021-2
B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma
resolves10.1111/j.1349-7006.2011.01877.x
B7‐H3 expression in gastric cancer: A novel molecular blood marker for detecting circulating tumor cells
resolves10.1016/j.juro.2011.04.103
B7-H3 Over Expression in Prostate Cancer Promotes Tumor Cell Progression
resolves10.1158/1078-0432.CCR-08-2262
Expression of Immunosuppresive B7-H3 Ligand by Hormone-Treated Prostate Cancer Tumors and Metastases
resolves10.1097/SLA.0b013e3181f1939d
B7–H3 Ligand Expression by Primary Breast Cancer and Associated With Regional Nodal Metastasis
resolves10.1016/j.lungcan.2009.01.017
Diagnosis value of serum B7-H3 expression in non-small cell lung cancer
resolves10.1016/j.ygyno.2011.09.012
Immunoexpression of B7-H3 in endometrial cancer: Relation to tumor T-cell infiltration and prognosis
resolves10.1002/ijc.26238
B7‐H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis‐associated genes
resolves10.1007/s00262-010-0841-1
Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma
resolves10.1016/j.yexcr.2012.09.006
Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response
resolves10.3892/ijo.2011.949
Expression of B7-H3 in hypopharyngeal squamous cell carcinoma as a predictive indicator for tumor metastasis and prognosis
resolves10.1016/S1074-7613(03)00147-X
B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation
resolves10.4049/jimmunol.171.9.4650
Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family
resolves10.1016/S1074-7613(03)00152-3
B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity
resolves10.1073/pnas.1434299100
B7x: A widely expressed B7 family member that inhibits T cell activation
resolves10.1016/j.bbrc.2009.08.144
Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses
resolves10.1371/journal.pone.0028232
B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation
resolves10.1182/blood-2008-01-133223
B7-H4–deficient mice display augmented neutrophil-mediated innate immunity
resolves10.4049/jimmunol.1201241
B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-reactive CD8 T Cells
resolves10.1084/jem.20100639
Tissue-specific expression of B7x protects from CD4 T cell–mediated autoimmunity
resolves10.1097/TP.0b013e318277229d
Endogenous Expression of B7-H4 Improves Long-term Murine Islet Allograft Survival
resolves10.1097/TP.0b013e318195e5fa
Local Expression of B7-H4 by Recombinant Adenovirus Transduction in Mouse Islets Prolongs Allograft Survival
resolves10.2337/db11-0375
Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes
resolves10.1371/journal.pmed.1000166
Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: A Mouse Model Informed by Clinical Data
resolves10.1007/s00268-011-1186-4
Clinical Significance of the B7‐H4 Coregulatory Molecule as a Novel Prognostic Marker in Gastric Cancer
resolves10.1002/jso.21722
Expression of B7‐H4 in blood of patients with gastric cancer predicts tumor progression and prognosis
resolves10.1007/s00262-010-0900-7
Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
resolves10.1177/147323001204000211
Enhanced T Cell Immunity by B7-H4 Downregulation in Nonsmall-Cell Lung Cancer Cell Lines
resolves10.1016/j.canlet.2011.11.017
Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: A potential mechanism of immune escape
resolves10.1097/CJI.0b013e31824212c4
Increase of Circulating B7-H4–Expressing CD68+ Macrophage Correlated With Clinical Stage of Lung Carcinomas
resolves10.1007/s00262-011-1017-3
B7-H4 expression associates with cancer progression and predicts patient’s survival in human esophageal squamous cell carcinoma
resolves10.1158/1078-0432.CCR-10-2268
B7-H4 Expression in Human Melanoma: Its Association with Patients' Survival and Antitumor Immune Response
resolves10.1007/s11060-008-9601-x
B7-H4 is preferentially expressed in non-dividing brain tumor cells and in a subset of brain tumor stem-like cells
resolves10.1016/j.canlet.2008.02.067
B7-H4 reverse signaling induces the apoptosis of EBV-transformed B cells through Fas ligand up-regulation
resolves10.1111/j.1365-2567.2009.03111.x
Cell cycle arrest induced by engagement of B7‐H4 on Epstein–Barr virus‐positive B‐cell lymphoma cell lines
resolves10.1084/jem.20090681
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans
resolves10.1084/jem.20102548
Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6
resolves10.4049/jimmunol.1201321
Mimicking an Induced Self Phenotype by Coating Lymphomas with the NKp30 Ligand B7-H6 Promotes NK Cell Cytotoxicity
resolves10.4049/jimmunol.1103495
An NKp30-Based Chimeric Antigen Receptor Promotes T Cell Effector Functions and Antitumor Efficacy In Vivo
resolves10.1084/jem.20100619
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
resolves10.1074/jbc.M109.077156
Differentiation of Embryonic Stem Cells 1 (Dies1) Is a Component of Bone Morphogenetic Protein 4 (BMP4) Signaling Pathway Required for Proper Differentiation of Mouse Embryonic Stem Cells
resolves10.1111/j.1349-7006.2010.01675.x
GI24 enhances tumor invasiveness by regulating cell surface membrane‐type 1 matrix metalloproteinase
resolves10.4049/jimmunol.1100660
Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models
The 1 reference without a DOI — listed, not checked
no DOI — not checkedT cell costimulation through the CD28 receptor
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