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Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect

https://doi.org/10.1016/j.jconrel.2021.01.036

43/43 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

4 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 43 checked references that resolve

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

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STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

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Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

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PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

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PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

resolves10.1158/2159-8290.CD-18-1020

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

resolves10.1158/0008-5472.CAN-18-1003

PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

resolves10.1172/JCI123319

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer

resolves10.1126/science.1232458

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

resolves10.1038/ni921

IKKε and TBK1 are essential components of the IRF3 signaling pathway

resolves10.1038/ni.3558

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

resolves10.1038/nri3845

Type I interferons in anticancer immunity

resolves10.1016/j.immuni.2018.09.016

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

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Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

resolves10.1038/s41586-018-0705-y

Design of amidobenzimidazole STING receptor agonists with systemic activity

resolves10.1038/s41422-020-0346-1

Old dogs, new trick: classic cancer therapies activate cGAS

resolves10.1126/science.abb4255

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

resolves10.1126/science.aba6098

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resolves10.1084/jem.20180139

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

resolves10.1016/j.ccell.2018.03.027

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells

resolves10.1038/ncomms15618

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

resolves10.1038/s41577-018-0117-0

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

resolves10.1038/s41590-020-0751-0

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

resolves10.1016/j.immuni.2018.03.017

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

resolves10.1038/nature23470

Mitotic progression following DNA damage enables pattern recognition within micronuclei

resolves10.1016/S0966-7822(98)00035-5

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Smart Ferrofluid with Quick Gel Transformation in Tumors for MRI‐Guided Local Magnetic Thermochemotherapy

resolves10.1038/nbt.2450

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resolves10.1186/s12859-018-2486-6

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Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition <i>via</i> a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects

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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

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TREX1 is a checkpoint for innate immune sensing of DNA damage that fosters cancer immune resistance

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Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease

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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

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Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

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Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

The 4 references without a DOI — listed, not checked

no DOI — not checkedRadiotherapy combination opportunities leveraging immunity for the next oncology practice

no DOI — not checkedMaterial properties of alginates

no DOI — not checkedTo determine the complexing constants of several alginates

no DOI — not checked10.1016/j.jconrel.2021.01.036_bb0190

What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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