Reference health
Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease
59/59 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 59 checked references that resolve
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Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
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Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis
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Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex
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Diagnostic Value of Pre-Contrast T1 Mapping in Acute and Chronic Myocardial Infarction
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RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
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Vitamin C Deficiency in the Brain Impairs Cognition, Increases Amyloid Accumulation and Deposition, and Oxidative Stress in APP/PSEN1 and Normally Aging Mice
resolves10.1038/sj.ijo.802225
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study
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Obesity, diabetes and cognitive deficit: The Framingham Heart Study
resolves10.3233/JAD-160150
Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer’s Disease Stage in APP/PS1 Mice
resolves10.1111/j.1601-183X.2008.00453.x
Cognitive and non‐cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer’s disease
resolves10.1038/srep21568
Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease
resolves10.1016/j.neurobiolaging.2010.05.026
AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation
resolves10.1001/archinte.163.13.1524
An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease
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Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze
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β-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer's Disease
resolves10.1016/j.neurobiolaging.2008.08.022
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
resolves10.1016/j.bbr.2014.01.044
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice
resolves10.1016/j.neurobiolaging.2014.02.010
High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
resolves10.1016/j.jnutbio.2013.09.015
Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition
resolves10.3389/fnins.2016.00232
Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction
resolves10.1007/s12035-010-8106-8
Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease
resolves10.1016/j.neurobiolaging.2011.10.028
Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice
resolves10.1074/jbc.M112.367011
Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice
resolves10.1371/journal.pone.0131199
High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation
resolves10.1016/j.jnutbio.2015.05.008
The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet
resolves10.1007/s00125-011-2160-2
Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein
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Prevalence of Childhood and Adult Obesity in the United States, 2011-2012
resolves10.3389/fncel.2014.00225
High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice
resolves10.1016/j.jneuroim.2009.11.010
Cognitive impairment following high fat diet consumption is associated with brain inflammation
resolves10.1016/j.biopsych.2009.02.013
Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders
resolves10.1371/journal.pone.0030378
Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity
resolves10.1016/j.psyneuen.2014.06.005
Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice
resolves10.3233/JAD-150980
Unraveling Alzheimer’s: Making Sense of the Relationship between Diabetes and Alzheimer’s Disease
resolves10.1111/cns.12144
Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in <scp>APP</scp>swe/<scp>PS</scp>1dE9 Transgenic Mice
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Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice
resolves10.1016/j.neuron.2006.01.022
Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease
resolves10.1016/j.neurobiolaging.2009.04.016
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
resolves10.1111/j.1471-4159.2008.05798.x
Effects of short‐term Western diet on cerebral oxidative stress and diabetes related factors in APP × PS1 knock‐in mice
resolves10.1159/000343211
Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat
resolves10.1073/pnas.1000645107
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes
resolves10.18632/oncotarget.12179
High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice
resolves10.1016/j.neurobiolaging.2016.06.006
Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging
resolves10.2337/db14-0375
Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease
resolves10.1096/fj.14-268482
Age‐dependent impairment of glucose tolerance in the 3xTg‐AD mouse model of Alzheimer's disease
resolves10.1038/sj.ijo.0803114
Interactive relations of central versus total obesity and blood pressure to cognitive function
resolves10.1016/j.bbr.2010.08.033
Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice
resolves10.2174/156720507780362047
Body Mass Index in Midlife and Risk of Alzheimer Disease and Vascular Dementia
resolves10.1007/s00109-009-0439-2
Receptor for AGE (RAGE) and its ligands—cast into leading roles in diabetes and the inflammatory response
resolves10.1016/j.neurobiolaging.2015.07.022
Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice
resolves10.1111/cbdd.12673
Geniposide Attenuates the Phosphorylation of Tau Protein in Cellular and Insulin‐deficient APP/PS1 Transgenic Mouse Model of Alzheimer's Disease
resolves10.1111/j.1471-4159.2010.07002.x
Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain
The 3 references without a DOI — listed, not checked
no DOI — not checkedWeight loss interventions in older adults with obesity: a systematic review of randomized controlled trials since 2005
no DOI — not checkedIncreased amyloid-levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet
no DOI — not checkedBlood-brain barrier leakage in patients with early Alzheimer disease
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