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Internal gate mutants of the GABA transporter GAT1 are capable of substrate exchange

https://doi.org/10.1016/j.neuropharm.2019.02.016
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35/35 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

The 35 checked references that resolve
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An Acidic Amino Acid Transmembrane Helix 10 Residue Conserved in the Neurotransmitter:Sodium:Symporters Is Essential for the Formation of the Extracellular Gate of the γ-Aminobutyric Acid (GABA) Transporter GAT-1
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Functional Defects in the External and Internal Thin Gates of the γ-Aminobutyric Acid (GABA) Transporter GAT-1 Can Compensate Each Other
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A Glutamine Residue Conserved in the Neurotransmitter:Sodium:Symporters Is Essential for the Interaction of Chloride with the GABA Transporter GAT-1
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Mutation of Arginine 44 of GAT-1, a (Na+ + Cl−)-coupled γ-Aminobutyric Acid Transporter from Rat Brain, Impairs Net Flux but Not Exchange
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Generation of an activating Zn <sup>2+</sup> switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
resolves10.1085/jgp.114.3.429
Gat1 (Gaba:Na+:Cl−) Cotransport Function
resolves10.1021/bi00445a026
Low-affinity .gamma.-aminobutyric acid transport in rat brain
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Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes
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Ion Binding and Permeation at the GABA Transporter GAT1
resolves10.1038/nsmb.2894
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters
resolves10.1038/ncomms11673
A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state
resolves10.1021/acs.biochem.6b00795
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resolves10.1016/S0021-9258(18)53681-4
Only one of the charged amino acids located in the transmembrane alpha-helices of the gamma-aminobutyric acid transporter (subtype A) is essential for its activity.
resolves10.1038/nature12533
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resolves10.1016/S0021-9258(17)39110-X
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Bi‐directional transport of GABA in human embryonic kidney (HEK‐293) cells stably expressing the rat GABA transporter GAT‐1
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