Reference health

Development of vaccines to treat opioid use disorders and reduce incidence of overdose

https://doi.org/10.1016/j.neuropharm.2019.06.001
CiteStamped reference-health badge
96/96 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

13 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 96 checked references that resolve
resolves10.1111/j.1470-8744.1999.tb00904.x
Design and synthesis of a morphine‐6‐succinyl‐bovine serum albumin hapten for vaccine development
resolves10.3923/jpt.2009.30.35
Immunotherapy of 347 Volunteer Outpatient Morphine Addicts by Human Therapeutic Morphine Vaccine in Kermanshah Province of Iran
resolves10.1016/j.drugalcdep.2006.09.012
Abuse liability of buprenorphine–naloxone tablets in untreated IV drug users
resolves10.1016/S0264-410X(02)00174-3
Design and selection of vaccine adjuvants: animal models and human trials
resolves10.1016/j.vaccine.2014.07.085
Adjuvants for vaccines to drugs of abuse and addiction
resolves10.4161/hv.5.4.7556
Vaccines against morphine/heroine and its use as effective medication for preventing relapse to opiate addictive behaviors
resolves10.1016/j.neuropharm.2017.10.016
Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review
resolves10.3389/fimmu.2013.00114
Mechanisms of Action of Adjuvants
resolves10.1021/acs.molpharmaceut.8b00592
Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins
resolves10.1016/j.jconrel.2018.02.006
Immune response to antigen adsorbed to aluminum hydroxide particles: Effects of co-adsorption of ALF or ALFQ adjuvant to the aluminum-antigen complex
resolves10.1073/pnas.0805942105
Isolation of human monoclonal antibodies by mammalian cell display
resolves10.1038/252708a0
Changes in heroin self-administration by a rhesus monkey after morphine immunisation
resolves10.1046/j.1360-0443.1999.9444894.x
Methadone‐maintained former heroin addicts, including those who are anti‐HIV‐1 seropositive, comply with and respond to hepatitis B vaccination
resolves10.1021/jm301262z
Investigating the Effects of a Hydrolytically Stable Hapten and a Th1 Adjuvant on Heroin Vaccine Performance
resolves10.1021/mp400631w
Injection Route and TLR9 Agonist Addition Significantly Impact Heroin Vaccine Efficacy
resolves10.1002/anie.201511654
Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs
resolves10.1021/jacs.7b03334
Development of a Clinically Viable Heroin Vaccine
resolves10.1097/ADM.0b013e3181b5a713
Prescription Opioid Use Among Patients Seeking Treatment for Opioid Dependence
resolves10.1086/508184
Buprenorphine Use: The International Experience
resolves10.1001/jama.2014.7404
Driven by Prescription Drug Abuse, Heroin Use Increases Among Suburban and Rural Whites
resolves10.1016/j.addbeh.2018.05.030
Increased use of heroin as an initiating opioid of abuse: Further considerations and policy implications
resolves10.1001/jama.2018.8826
Helping to End Addiction Over the Long-term
resolves10.1124/jpet.102.038141
Self-Administration of Intravenous Buprenorphine and the Buprenorphine/Naloxone Combination by Recently Detoxified Heroin Abusers
resolves10.1007/s002130100909
Depot naltrexone: long-lasting antagonism of the effects of heroin in humans
resolves10.1371/journal.pone.0082557
Immunogenicity of Individual Vaccine Components in a Bivalent Nicotine Vaccine Differ According to Vaccine Formulation and Administration Conditions
resolves10.1146/annurev-immunol-031210-101400
Follicular Helper CD4 T Cells (T<sub>FH</sub>)
resolves10.1038/nri3803
A brief history of T cell help to B cells
resolves10.1586/erv.13.13
Therapeutic vaccines against tobacco addiction
resolves10.1016/j.vaccine.2014.02.024
Generation of a universal CD4 memory T cell recall peptide effective in humans, mice and non-human primates
resolves10.1016/S2215-0366(18)30337-7
The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
resolves10.1016/j.clpt.2005.08.007
Safety and immunogenicity of a nicotine conjugate vaccine in current smokers
resolves10.1038/clpt.2010.317
Immunogenicity and Smoking-Cessation Outcomes for a Novel Nicotine Immunotherapeutic
resolves10.1080/15563650.2017.1303141
Intoxications involving acrylfentanyl and other novel designer fentanyls – results from the Swedish STRIDA project
resolves10.1016/S0022-3565(25)30084-4
Antibodies to fentanyl.
resolves10.4049/jimmunol.114.4.1363
Delayed Clearance of Morphine from the Circulation of Rabbits Immunized with Morphine-6-Hemisuccinate Bovine Serum Albumin
resolves10.1021/acsomega.8b01478
Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
resolves10.1021/acschemneuro.8b00079
Efficacious Vaccine against Heroin Contaminated with Fentanyl
resolves10.1021/acs.molpharmaceut.7b00933
Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality
resolves10.1016/j.bmc.2018.11.027
Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin
resolves10.1021/acs.bioconjchem.5b00085
Efficacy, but Not Antibody Titer or Affinity, of a Heroin Hapten Conjugate Vaccine Correlates with Increasing Hapten Densities on Tetanus Toxoid, but Not on CRM<sub>197</sub>Carriers
resolves10.1001/jama.2018.2844
Changes in Synthetic Opioid Involvement in Drug Overdose Deaths in the United States, 2010-2016
resolves10.1016/0091-3057(78)90295-2
Effects of passive immunization against morphine on heroin self-administration
resolves10.1021/acschembio.6b00977
An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life
resolves10.1016/j.pnpbp.2013.05.012
A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats
resolves10.1111/bcp.12115
Vaccines against stimulants: cocaine and <scp>MA</scp>
resolves10.1016/j.drugalcdep.2014.04.003
Vaccine for cocaine dependence: A randomized double-blind placebo-controlled efficacy trial
resolves10.4049/jimmunol.1500385
The Frequency of Naive and Early-Activated Hapten-Specific B Cell Subsets Dictates the Efficacy of a Therapeutic Vaccine against Prescription Opioid Abuse
resolves10.1016/j.vaccine.2015.09.015
The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence
resolves10.1038/s41598-018-23777-6
Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose
resolves10.1093/ijnp/pyu093
A Conjugate Vaccine Attenuates Morphine- and Heroin-Induced Behavior in Rats
resolves10.1021/mp500520r
Flagellin as Carrier and Adjuvant in Cocaine Vaccine Development
resolves10.1001/archgenpsychiatry.2009.128
Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients
resolves10.1016/j.vaccine.2013.04.027
Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs
resolves10.1016/j.vaccine.2014.01.028
Facial recognition of heroin vaccine opiates: Type 1 cross-reactivities of antibodies induced by hydrolytically stable haptenic surrogates of heroin, 6-acetylmorphine, and morphine
resolves10.1002/eji.200526285
A therapeutic vaccine for nicotine dependence: preclinical efficacy, and phase I safety and immunogenicity
resolves10.1016/j.intimp.2015.02.030
Molecular attributes of conjugate antigen influence function of antibodies induced by anti-nicotine vaccine in mice and non-human primates
resolves10.1038/nri3128
Molecular programming of B cell memory
resolves10.1016/j.vaccine.2016.01.051
Active opioid use does not attenuate the humoral responses to inactivated influenza vaccine
resolves10.1016/0376-8716(94)90161-9
Determination of naltrexone dosage for narcotic agonist blockade in detoxified Asian addicts
resolves10.1016/j.neuropharm.2018.06.026
Prophylactic vaccination protects against the development of oxycodone self-administration
resolves10.1046/j.1360-0443.2001.96226710.x
Injecting misuse of buprenorphine among French drug users
resolves10.1016/B978-0-12-420118-7.00014-7
New Directions in Nicotine Vaccine Design and Use
resolves10.1016/j.vaccine.2012.04.101
Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats
resolves10.1124/jpet.111.189506
An Oxycodone Conjugate Vaccine Elicits Drug-Specific Antibodies that Reduce Oxycodone Distribution to Brain and Hot-Plate Analgesia
resolves10.1021/jm3013745
Reduced Antinociception of Opioids in Rats and Mice by Vaccination with Immunogens Containing Oxycodone and Hydrocodone Haptens
resolves10.1371/journal.pone.0096547
Effect of Currently Approved Carriers and Adjuvants on the Pre-Clinical Efficacy of a Conjugate Vaccine against Oxycodone in Mice and Rats
resolves10.1371/journal.pone.0101807
Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats
resolves10.1124/jpet.112.201194
Selective Effects of a Morphine Conjugate Vaccine on Heroin and Metabolite Distribution and Heroin-Induced Behaviors in Rats
resolves10.1371/journal.pone.0115696
Pharmacokinetic Correlates of the Effects of a Heroin Vaccine on Heroin Self-Administration in Rats
resolves10.1371/journal.pone.0184876
Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse
resolves10.1124/jpet.117.247049
Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats
resolves10.1124/jpet.118.253674
A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats
resolves10.1093/jat/bks078
Analysis of Clothing and Urine from Moscow Theatre Siege Casualties Reveals Carfentanil and Remifentanil Use
resolves10.1080/21645515.2018.1558697
Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders
resolves10.1016/S0140-6736(18)31073-0
Tramadol: Africa's opioid crisis
resolves10.1073/pnas.1219159110
Dynamic vaccine blocks relapse to compulsive intake of heroin
resolves10.1007/s002130051045
Onset, magnitude and duration of opioid blockade produced by buprenorphine and naltrexone in humans
resolves10.1021/jm200461m
A Vaccine Strategy that Induces Protective Immunity against Heroin
resolves10.1021/acs.jmedchem.7b01427
A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse
resolves10.24095/hpcdp.38.6.01
Commentary - Building the evidence base for sustained public health response to the opioid epidemic in Canada
resolves10.1038/sj.icb.7100148
Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre
resolves10.1016/j.jmb.2011.10.042
Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody
resolves10.1016/j.jim.2014.01.010
Hapten-specific naïve B cells are biomarkers of vaccine efficacy against drugs of abuse
resolves10.1038/s41541-017-0013-9
Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant
resolves10.1038/253565a0
Prevention of the effects of fentanyl by immunological means
resolves10.1002/cpt1976203315
Naltrexone: Disposition, metabolism, and effects after acute and chronic dosing
resolves10.1016/j.coi.2014.02.010
Clonal and cellular dynamics in germinal centers
resolves10.1056/NEJMsr1706626
The Role of Science in Addressing the Opioid Crisis
resolves10.1126/science.176.4039.1143
Morphine-3-Succinyl—Bovine Serum Albumin: An Immunogenic Hapten-Protein Conjugate
resolves10.4049/jimmunol.110.3.667
A Measurement of the Specificities of Antibodies to Morphine-6-Succinyl-BSA by Competitive Inhibition of 14C-Morphine Binding
resolves10.1038/241537a0
In vitro Morphine Antagonism by Antibodies
resolves10.1038/clpt.1994.71
Clinical pharmacology of buprenorphine: Ceiling effects at high doses
resolves10.1007/BF02246290
Effects of buprenorphine and methadone in methadone-maintained subjects
resolves10.1002/jps.21523
Vaccine adjuvants: Current challenges and future approaches
resolves10.1166/jbn.2015.2156
Negatively Charged Carbon Nanohorn Supported Cationic Liposome Nanoparticles: A Novel Delivery Vehicle for Anti-Nicotine Vaccine
The 13 references without a DOI — listed, not checked
no DOI — not checkedPrevention of prescription opioid misuse and projected overdose deaths in the United States
no DOI — not checked10.1016/j.neuropharm.2019.06.001_bib29
no DOI — not checkedDrug overdose deaths in the United States, 1999-2016
no DOI — not checkedThe interaction of 14C-morphine with sera from immunized rabbits and from patients addicted to heroin
no DOI — not checked10.1016/j.neuropharm.2019.06.001_bib47
no DOI — not checkedTackling subutex abuse in Singapore
no DOI — not checkedA protocol to switch high-dose, methadone-maintained subjects to buprenorphine
no DOI — not checkedBiologics to treat substance use disorders: current status and new directions
no DOI — not checked10.1016/j.neuropharm.2019.06.001_bib86
no DOI — not checkedProceedings: immunopharmacology of a potent opiate, fentanyl. Development of radioimmunoassay and prevention of effects by immunologic means
no DOI — not checked10.1016/j.neuropharm.2019.06.001_bib96
no DOI — not checked10.1016/j.neuropharm.2019.06.001_bib106
no DOI — not checkedA Nanoparticle-Based Nicotine Vaccine and the Influence of Particle Size on its Immunogenicity and Efficacy
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

checked 2026-07-23 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record

Embed this badge

Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.

<a href="https://citestamp.com/citestamped/10.1016/j.neuropharm.2019.06.001"><img src="https://citestamp.com/citestamped/10.1016/j.neuropharm.2019.06.001/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>
[![CiteStamped reference-health badge](https://citestamp.com/citestamped/10.1016/j.neuropharm.2019.06.001/badge.svg)](https://citestamp.com/citestamped/10.1016/j.neuropharm.2019.06.001)