Reference health
Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity
2 of 67 checkable references need attention · checked 2026-07-23
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
9 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
marked retracted — notice via Crossref, record curated by Retraction Watch10.1074/jbc.M511198200
Phosphorylation of Tyrosine 568 Controls Nuclear Export of Nrf2
marked retracted — notice via Crossref, record curated by Retraction Watch10.1073/pnas.96.17.9879
RETRACTED: A new mechanism of neurodegeneration: A proinflammatory cytokine inhibits receptor signaling by a survival peptide
The 65 checked references that resolve
resolves10.1046/j.1471-4159.1996.66010006.x
Cyclooxygenase‐2 Induction in Cerebral Cortex: An Intracellular Response to Synaptic Excitation
resolves10.1074/jbc.274.37.26071
Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene
resolves10.1007/s00018-003-3319-x
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
resolves10.1016/j.tips.2008.02.003
Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke
resolves10.1016/j.tibs.2004.03.006
Advances in protein kinase B signalling: AKTion on multiple fronts
resolves10.1016/j.clineuro.2009.04.001
The complexity of neurobiological processes in acute ischemic stroke
resolves10.1016/j.pharmthera.2015.11.003
Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
resolves10.3233/JAD-151189
Aging Enables Ca2+ Overload and Apoptosis Induced by Amyloid-β Oligomers in Rat Hippocampal Neurons: Neuroprotection by Non-Steroidal Anti-Inflammatory Drugs and R-Flurbiprofen in Aging Neurons
resolves10.1073/pnas.96.15.8745
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
resolves10.1515/revneuro-2013-0046
Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications
resolves10.1016/j.molbrainres.2005.03.004
Inhibition of GSK3β is a common event in neuroprotection by different survival factors
resolves10.1038/onc.2012.388
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
resolves10.1038/378785a0
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
resolves10.21010/ajtcam.v14i5.18
ANTIOXIDANT PROPERTIES OF DICHROCEPHALA INTEGRIFOLIA (ASTERACEAE) IN A MOUSE MODEL OF MONOSODIUM GLUTAMATE-INDUCED NEUROTOXICITY
resolves10.1172/JCI18162
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
resolves10.1128/MCB.20.3.929-935.2000
Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane
resolves10.1191/0960327106ht621oa
Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin
resolves10.1016/j.mcn.2003.08.005
Glutamate excitotoxicity attenuates insulin-like growth factor-i prosurvival signaling
resolves10.1016/j.brainresrev.2004.12.029
Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease
resolves10.1016/S0301-0082(01)00011-9
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
resolves10.1016/B978-0-12-386931-9.00013-1
Receptor Heteromeric Assembly—How It Works and Why It Matters
resolves10.1074/jbc.M500939200
Distinct Mechanistic Roles of Calpain and Caspase Activation in Neurodegeneration as Revealed in Mice Overexpressing Their Specific Inhibitors
resolves10.1016/j.pbb.2011.04.013
Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances
resolves10.1126/science.7522345
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase
resolves10.3390/molecules22111928
Ginger and Propolis Exert Neuroprotective Effects against Monosodium Glutamate-Induced Neurotoxicity in Rats
resolves10.1074/jbc.M611336200
GSK-3β Acts Upstream of Fyn Kinase in Regulation of Nuclear Export and Degradation of NF-E2 Related Factor 2
resolves10.1146/annurev.pharmtox.46.120604.141046
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
resolves10.1021/jf300548b
Neuroprotective Effects of Dehydroglyasperin C through Activation of Heme Oxygenase-1 in Mouse Hippocampal Cells
resolves10.1007/s12035-020-02087-x
The Role of Brain Cyclooxygenase-2 (Cox-2) Beyond Neuroinflammation: Neuronal Homeostasis in Memory and Anxiety
resolves10.1074/jbc.271.40.24794
Sustained Induction of Prostaglandin Endoperoxide Synthase-2 by Seizures in Hippocampus
resolves10.1126/science.281.5385.2027
Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
resolves10.1016/j.ejphar.2012.10.032
Excitotoxicity: Bridge to various triggers in neurodegenerative disorders
resolves10.1016/j.neuropharm.2010.08.015
Neuroprotective effect of flurbiprofen in focal cerebral ischemia: The possible role of ASIC1a
resolves10.1254/jphs.12274SC
Prostaglandin E2-Induced Cell Death is Mediated by Activation of EP2 Receptors in Motor Neuron-like NSC-34 Cells
resolves10.2174/1566524043479239
Mitochondrial Dysfunction and Glutamate Excitotoxicity Studied in Primary Neuronal Cultures
resolves10.1074/jbc.M111.312694
Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis
resolves10.1074/jbc.M105710200
Up-regulation of Functionally Impaired Insulin-like Growth Factor-1 Receptor in Scrapie-infected Neuroblastoma Cells
resolves10.1007/BF00966860
The osmotic/calcium stress theory of brain damage: Are free radicals involved?
resolves10.1073/pnas.98.4.1676
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
resolves10.1038/ncomms3034
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
resolves10.1016/0003-9861(91)90224-7
Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide
resolves10.1016/j.neuroscience.2011.08.052
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function
resolves10.1111/j.1471-4159.2007.05124.x
GSK‐3β down‐regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress
resolves10.1016/j.physbeh.2015.11.038
Diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal BDNF-Akt pathway and uptake of GABA and serotonin neurotransmitters
resolves10.1124/jpet.103.049700
Inhibitors of Cyclooxygenase-2, but Not Cyclooxygenase-1 Provide Structural and Functional Protection against Quinolinic Acid-Induced Neurodegeneration
resolves10.2174/1567205015666171227154016
Is it All Said for NSAIDs in Alzheimer’s Disease? Role of Mitochondrial Calcium Uptake
resolves10.1371/journal.pone.0002718
Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs
resolves10.1016/j.bbrc.2011.05.095
The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats
resolves10.1021/acs.jnatprod.5b00220
Neolignans from <i>Aristolochia fordiana</i> Prevent Oxidative Stress-Induced Neuronal Death through Maintaining the Nrf2/HO-1 Pathway in HT22 Cells
resolves10.1038/8216
resolves10.1016/S1474-4422(09)70043-2
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
resolves10.1016/0003-2697(78)90342-1
Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
resolves10.1080/1028415X.2017.1398301
Monosodium glutamate and treadmill exercise: Anxiety-like behavior and spreading depression features in young adult rats
resolves10.3892/ol.2020.11993
Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2
resolves10.1016/0896-6273(93)90192-T
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
resolves10.1016/j.neuint.2005.12.001
Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury
The 9 references without a DOI — listed, not checked
no DOI — not checkedExcitotoxicity and nitric oxide in Parkinson's disease pathogenesis
no DOI — not checkedGlutamate excitotoxicity and neurodegeneration
no DOI — not checked'Biology of disease: free radicals and tissue injury
no DOI — not checked10.1016/j.neuropharm.2021.108654_bib41
no DOI — not checked10.1016/j.neuropharm.2021.108654_bib52
no DOI — not checkedNeuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats
no DOI — not checkedDeterimination of nitric oxide via measurement of nitrite and nitrate in culture media
no DOI — not checked'The effect of monosodium glutamate and aspartame on rat hippocampal N-methyl-D-aspartate receptor subunits and oxidative stress biomarkers
no DOI — not checked'Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway
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