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Machine learning enables discovery of Gentianine targeting TLR4/NF-κB pathway to repair ischemic stroke injury

https://doi.org/10.1016/j.phrs.2021.105913
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28/28 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

7 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 28 checked references that resolve
resolves10.1161/CIR.0000000000000558
Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association
resolves10.1161/01.STR.24.1.35
Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.
resolves10.1038/nrn1106
Mechanisms, challenges and opportunities in stroke
resolves10.1080/14728222.2019.1676416
Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders
resolves10.1186/s12974-018-1388-x
Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway
resolves10.1016/j.phrs.2020.104935
Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes
resolves10.1142/S0192415X21500622
The Impact of Artificial Intelligence on Traditional Chinese Medicine
resolves10.1002/ptr.4763
Anti‐diabetic Activity of Swertiamarin is due to an Active Metabolite, Gentianine, that Upregulates PPAR‐γ Gene Expression in 3T3‐L1 cells
resolves10.1002/jps.2600630850
Chemical Constituents of Gentianaceae XI: Antipsychotic Activity of Gentianine
resolves10.1007/s10753-017-0583-8
Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund’s Complete Adjuvant-Induced Arthritis in Rats
resolves10.4103/wjtcm.wjtcm_3_21
Molecular Docking-Based Research on the Potential Anti-Encephalopathy Effect of Gentianine
resolves10.1093/nar/gky1021
SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping
resolves10.21037/apm-21-531
Network pharmacology study on the mechanism of the herb pair of prepared Rehmannia root-Chinese arborvitae kernel for anxiety disorders
resolves10.7717/peerj-cs.289
Database limitations for studying the human gut microbiome
resolves10.1016/j.intimp.2020.107014
Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway
resolves10.1177/0271678X19882264
miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model
resolves10.3892/mmr.2020.11637
Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF‑κB signaling pathway
resolves10.1371/journal.pone.0078902
An Effective Solution to Discover Synergistic Drugs for Anti-Cerebral Ischemia from Traditional Chinese Medicinal Formulae
resolves10.3390/molecules171113403
By Improving Regional Cortical Blood Flow, Attenuating Mitochondrial Dysfunction and Sequential Apoptosis Galangin Acts as a Potential Neuroprotective Agent after Acute Ischemic Stroke
resolves10.1021/acs.chemrestox.0c00323
Trelagliptin Mitigates Macrophage Infiltration by Preventing the Breakdown of the Blood–Brain Barrier in the Brain of Middle Cerebral Artery Occlusion Mice
resolves10.1038/srep16151
Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia
resolves10.21037/atm-20-5115
Ulinastatin alleviates cerebral ischemia-reperfusion injury in rats by activating the Nrf-2/HO-1 signaling pathway
resolves10.1038/s41598-017-18935-1
Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells
resolves10.1038/s41572-019-0118-8
Ischaemic stroke
resolves10.1038/s41593-018-0242-x
Microglia in neurodegeneration
resolves10.1007/s00401-012-1076-3
The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury
resolves10.1007/s00018-018-2953-2
The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4
resolves10.1186/s12974-018-1246-x
The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation
The 7 references without a DOI — listed, not checked
no DOI — not checkedAn effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae
no DOI — not checkedDecoction for the treatment of 30 cases of liver and gall damp-heat stroke
no DOI — not checkedLongdan xiegan decoction in the treatment of 100 cases of Stroke
no DOI — not checkedEffect of Longdan qingxie huoxue decoction on the clinical treatment of acute cerebral hemorrhage with phlegm fire stasis syndrome
no DOI — not checkedSedative and hypnotic effects of gentian and its effect on 5-HT and GABA contents in brain of mice
no DOI — not checkedStudy on antipyretic effect and its mechanism of Gentianine
no DOI — not checkedGentianine protects hippocampal neurons in a rat model of recurrent febrile convulsion
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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