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Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways
38/38 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
5 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 38 checked references that resolve
resolves10.1111/j.1365-2826.2012.02348.x
GDNF Contributes to Oestrogen‐Mediated Protection of Midbrain Dopaminergic Neurones
resolves10.1111/jphp.12166
Suppression of mast cell activity contributes to the osteoprotective effect of an herbal formula containing Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psoraleae
resolves10.1017/S0007114510003247
Total flavonoid fraction of the <i>Herba epimedii</i> extract suppresses urinary calcium excretion and improves bone properties in ovariectomised mice
resolves10.1016/j.neuint.2013.03.018
Involvement of IGF-I receptor and estrogen receptor pathways in the protective effects of ginsenoside Rg1 against Aβ25–35-induced toxicity in PC12 cells
resolves10.1155/2015/895976
Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway
resolves10.1016/j.bbrc.2008.09.001
Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells
resolves10.1007/s11064-011-0428-z
Effect of Different Doses of Estrogen on the Nigrostriatal Dopaminergic System in Two 6-Hydroxydopamine-Induced Lesion Models of Parkinson’s Disease
resolves10.1113/jphysiol.2005.089458
Cell type‐specific action of seizure‐induced intracellular zinc accumulation in the rat hippocampus
resolves10.1523/JNEUROSCI.12-09-03392.1992
A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin
resolves10.1124/mol.105.018671
Implication of the Phosphatidylinositol-3 Kinase/Protein Kinase B Signaling Pathway in the Neuroprotective Effect of Estradiol in the Striatum of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice
resolves10.1371/journal.pone.0095731
The Secretome of Endothelial Progenitor Cells Promotes Brain Endothelial Cell Activity through PI3-Kinase and MAP-Kinase
resolves10.1016/0092-8674(95)90534-0
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
resolves10.1016/j.jep.2009.09.038
Ginsenoside Rg1 protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways
resolves10.1016/j.brainres.2010.03.084
Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice
resolves10.1016/j.ejphar.2016.05.031
Involvement of IGF-1 receptor signaling pathway in the neuroprotective effects of Icaritin against MPP + -induced toxicity in MES23.5 cells
resolves10.1016/j.lfs.2015.01.006
Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii
resolves10.1016/j.neures.2007.10.005
Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease
resolves10.1002/mds.23388
Gender differences in Parkinson's disease: Clinical characteristics and cognition
resolves10.1111/j.1476-5381.2009.00593.x
Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor‐dependent osteoblastic functions in UMR 106 cells
resolves10.1016/j.ejphar.2009.09.039
Icariin inhibits beta-amyloid peptide segment 25–35 induced expression of β-secretase in rat hippocampus
resolves10.1016/j.nbd.2005.01.026
Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids
resolves10.1074/jbc.275.15.10761
Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein
resolves10.1016/S0969-9961(03)00108-6
Behavioral changes are not directly related to striatal monoamine levels, number of nigral neurons, or dose of parkinsonian toxin MPTP in mice
resolves10.1016/S0166-4328(01)00309-6
Behavioral phenotyping of the MPTP mouse model of Parkinson's disease
resolves10.1002/jnr.22416
BDNF‐Akt‐Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects
resolves10.1016/j.expneurol.2014.03.010
Sex differences in Parkinson's disease and other movement disorders
resolves10.1016/j.ejphar.2013.05.039
Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation
resolves10.3390/molecules15117861
Herba Epimedii: Anti-Oxidative Properties and Its Medical Implications
resolves10.1016/j.jep.2012.05.056
Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats
resolves10.1016/j.jsbmb.2014.02.019
Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERα) and stimulate ER-dependent osteoblastic functions in UMR-106 cells
resolves10.1007/s11481-013-9514-0
The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-Induced Neurotoxicity via Inhibition of Mitochondrial-Dependent Apoptosis
resolves10.1590/S1415-475738120140137
Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis
resolves10.3892/mmr.2012.1041
Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway
resolves10.7150/ijbs.6232
Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease
resolves10.1016/j.neuropharm.2010.03.017
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke
The 5 references without a DOI — listed, not checked
no DOI — not checkedIGF-I neuroprotection in the immature brain after hypoxia-ischemia, involvement of Akt and GSK3 beta? Eur
no DOI — not checkedIcariin enhances the osteogenic differentiation of bone marrow stromal cells but has no effects on the differentiation of newborn calvarial osteoblasts of rats
no DOI — not checkedDescription of a new method of ovariectomy in female rats
no DOI — not checkedIncreased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis
no DOI — not checkedIcariin prevents amyloid beta-induced apoptosis via the PI3K/Akt Pathway in PC-12 Cells
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