Reference health
Rosa canina – Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis – A systematic review
80/80 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
14 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 80 checked references that resolve
resolves10.1002/art.22174
Large‐scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
resolves10.1038/ejcn.2011.203
Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons
resolves10.2174/1381612824666181010151849
Phytochemistry, Traditional Uses and Pharmacological Profile of Rose Hip: A Review
resolves10.1016/j.joca.2011.12.012
Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs
resolves10.3390/ijms19082282
Onset and Progression of Human Osteoarthritis—Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?
resolves10.1016/j.freeradbiomed.2018.08.038
Reactive oxygen species, aging and articular cartilage homeostasis
resolves10.1016/j.autrev.2018.06.002
Osteoarthritis and its management - Epidemiology, nutritional aspects and environmental factors
resolves10.1007/s00441-009-0887-6
Proteinases involved in matrix turnover during cartilage and bone breakdown
resolves10.1371/journal.pone.0031318
Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT
resolves10.1016/j.phrs.2016.10.029
The genus Rosa and arthritis: Overview on pharmacological perspectives
resolves10.1016/j.joca.2008.03.001
Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients? – a meta-analysis of randomized controlled trials
resolves10.1016/j.jep.2007.03.029
In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits
resolves10.1155/2018/7402947
The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine
resolves10.7326/0003-4819-133-8-200010170-00016
Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors
resolves10.1016/j.joca.2015.02.020
Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway
resolves10.3109/03009748809102953
Characterization of Synovial Macrophages by Monoclonal Antibodies in Rheumatoid Arthritis and Osteoarthritis
resolves10.1002/ptr.2446
Isolation of linoleic and <i>α</i>‐linolenic acids as COX‐1 and ‐2 inhibitors in rose hip
resolves10.1371/journal.pone.0159136
Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer
resolves10.1016/S1063-4584(08)60003-5
Laboratory and preclinical studies on the anti-inflammatory and anti-oxidant properties of rosehip powder – Identification and characterization of the active component GOPO®
resolves10.1007/s10787-999-0031-y
Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo
resolves10.1007/s12272-011-1213-x
Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages
resolves10.1007/BF02973908
Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells
resolves10.1016/j.phymed.2011.02.008
The effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: A prospective cohort study
resolves10.1016/j.joca.2018.09.007
Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet
resolves10.1021/np0300636
An Antiinflammatory Galactolipid from Rose Hip (<i>Rosa </i><i>c</i><i>anina</i>) that Inhibits Chemotaxis of Human Peripheral Blood Neutrophils in Vitro
resolves10.1136/annrheumdis-2016-209757
Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis
resolves10.1016/j.lfs.2018.12.014
USP14-mediated IκBα degradation exacerbates NF-κB activation and IL-1β-stimulated chondrocyte dedifferentiation
resolves10.1155/2018/7857251
Mitochondrial Antioxidants and the Maintenance of Cellular Hydrogen Peroxide Levels
resolves10.1515/znc-2018-0122
Analysis of the GC-MS of volatile compounds and the phytochemical profile and antioxidant activities of some Bulgarian medicinal plants
resolves10.1055/s-0043-112750
A Rosa canina – Urtica dioica – Harpagophytum procumbens/zeyheri Combination Significantly Reduces Gonarthritis Symptoms in a Randomized, Placebo-Controlled Double-Blind Study
resolves10.1016/j.foodchem.2015.07.089
Comparative study of biological activities and phytochemical composition of two rose hips and their preserves: Rosa canina L. and Rosa arvensis Huds.
resolves10.1007/s13765-014-4020-5
Rose hip alleviates pain and disease progression in rats with monoiodoacetate induced osteoarthritis
resolves10.1016/j.bcp.2015.12.012
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
resolves10.1016/j.biopha.2018.05.003
Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats
resolves10.3389/fbioe.2018.00022
Interplay of Inflammatory Mediators with Epigenetics and Cartilage Modifications in Osteoarthritis
resolves10.1016/j.phymed.2004.01.001
A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis—a double-blind, placebo-controlled, randomised trial
resolves10.3390/metabo8040092
The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology
resolves10.1074/mcp.M800292-MCP200
Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics
resolves10.1002/ptr.3241
Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (<i>Rosa canina</i> L.)
resolves10.1002/ptr.3713
Triterpene Acids from Rose Hip Powder Inhibit Self‐antigen‐ and LPS‐induced Cytokine Production and CD4<sup>+</sup> T‐cell Proliferation in Human Mononuclear Cell Cultures
resolves10.1186/1472-6882-11-105
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression
resolves10.1155/2014/105710
A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects
resolves10.1136/ard.2009.119966
Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
resolves10.1155/2012/509383
Botanical Extracts from Rosehip (<i>Rosa canina</i>), Willow Bark (Salix alba), and Nettle Leaf (<i>Urtica dioica</i>) Suppress IL-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="bold">β</mml:mi></mml:math>-Induced NF-κB Activation in Canine Articular Chondrocytes
resolves10.5604/15093492.1240791
Genetic and Epigenetic Interactions in the Etiopathogenesis of Osteoarthritis. Selected Molecular Factors in OA Etiopathogenesis
resolves10.1155/MI.2005.343
RANTES and Chemotactic Activity in Synovial Fluids From Patients With Rheumatoid Arthritis andOsteoarthritis
resolves10.3889/oamjms.2018.422
Elevated High-Sensitivity C-Reactive Protein And Interleukin-6 Plasma As Risk Factors For Symptomatic Lumbar Osteoarthritis In Postmenopausal Women
resolves10.1002/ptr.3519
The Effects of the Hydroalcohol Extract of <i>Rosa canina</i> L. Fruit on Experimentally Nephrolithiasic Wistar Rats
resolves10.1093/rheumatology/key011
What is the evidence for a role for diet and nutrition in osteoarthritis?
resolves10.1016/j.bbapap.2011.06.020
Proteases involved in cartilage matrix degradation in osteoarthritis
resolves10.1016/j.cytogfr.2018.10.002
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
resolves10.1016/S0011-393X(03)00004-3
The Effects of a Standardized Herbal Remedy Made from a Subtype of Rosa canina in Patients with Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
resolves10.1016/j.phymed.2008.06.012
Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations
resolves10.1016/j.phymed.2009.09.003
Rose hip herbal remedy in patients with rheumatoid arthritis – a randomised controlled trial
resolves10.1080/03009740510018624
A powder made from seeds and shells of a rose‐hip subspecies (<i>Rosa canina</i>) reduces symptoms of knee and hip osteoarthritis: a randomized, double‐blind, placebo‐controlled clinical trial
resolves10.1016/j.biopha.2019.108610
Anthocyanins and metabolites from purple rice inhibit IL-1β-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-κB and ERK/MAPK pathway
resolves10.2147/TCRM.S175854
Preoperatively elevated serum inflammatory markers increase the risk of periprosthetic joint infection following total knee arthroplasty in patients with osteoarthritis
resolves10.1016/j.joca.2017.02.791
ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’
resolves10.3390/ijms18112491
Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression
The 14 references without a DOI — listed, not checked
no DOI — not checked[Composition and content of biologically active substances in rose hips]
no DOI — not checked10.1016/j.phymed.2019.152958_bib0012
no DOI — not checked10.1016/j.phymed.2019.152958_bib0016
no DOI — not checkedRosa canina fruit (rosehip) for osteoarthritis: a cochrane review
no DOI — not checkedKaempferol inhibits interleukin1beta stimulated matrix metalloproteinases by suppressing the MAPKassociated ERK and P38 signaling pathways
no DOI — not checkedNF-kappaB signaling in inflammation
no DOI — not checkedAntidiabetic effect and antioxidant potential of Rosa canina fruits
no DOI — not checkedRosa canina L. Fruit Hydro-Alcoholic Extract Effects on Some Immunological and Biochemical Parameters in Rats
no DOI — not checkedFree radicals in primary knee osteoarthritis
no DOI — not checkedEffects of different maturity periods and processes on nutritional components of rose hip (Rosa canina L.)
no DOI — not checkedLow-dose seed and shell powder from rose-hip (Rosa canina) can aleviate symptoms of osteoarthritis and reduce c-reactive protein in patients suffering from osteoarthritis
no DOI — not checkedShells from rose-hip (Rosa canina) do not reduce symptom scores or improve anti-inflammatory property in patients with osteoarthritis – a double-blind, placebo-controlled, randomized study
no DOI — not checked10.1016/j.phymed.2019.152958_bib0054
no DOI — not checkedAntibacterial and antioxidant activity of fruits of some rose species from Turkey
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