Reference health
Lipid accumulation in non-adipose tissue and lipotoxicity
117/117 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
5 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 117 checked references that resolve
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Diseases of liporegulation: new perspective on obesity and related disorders
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Trends in Heart Failure Incidence and Survival in a Community-Based Population
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Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
resolves10.1073/pnas.0405499101
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
resolves10.1096/fj.04-2263com
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
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The Increase in Intramyocellular Lipid Content Is a Very Early Response to Training
resolves10.1007/s11745-000-0647-2
<i>In vivo</i> evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans
resolves10.1210/jc.85.2.748
Intramuscular Glycogen and Intramyocellular Lipid Utilization during Prolonged Exercise and Recovery in Man: A 13C and 1H Nuclear Magnetic Resonance Spectroscopy Study
resolves10.1002/mrm.1910370403
<i>In vivo</i> determination of intra‐myocellular lipids in human muscle by means of localized <sup>1</sup>H‐MR‐spectroscopy
resolves10.1055/s-2001-12407
Utilisation of Intramyocellular Lipids (IMCLs) During Exercise as Assessed by Proton Magnetic Resonance Spectroscopy (1H-MRS)
resolves10.1152/jappl.1996.81.3.1150
Variability of triacylglycerol content in human skeletal muscle biopsy samples
resolves10.2337/diabetes.48.5.1113
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.
resolves10.1007/s001250051123
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study
resolves10.1210/jc.86.12.5755
Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes
resolves10.1210/jc.2002-021674
Intramyocellular Lipids: Anthropometric Determinants and Relationships with Maximal Aerobic Capacity and Insulin Sensitivity
resolves10.1002/dmr.5610020101
Exercise and physical training: Effects on insulin sensitivity and glucose metabolism
resolves10.2337/diabetes.32.5.408
Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans
resolves10.1249/01.MSS.0000069336.30649.BD
Effects of Dietary Fat on Muscle Substrates, Metabolism, and Performance in Athletes
resolves10.1113/jphysiol.2001.012933
Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans
resolves10.1152/japplphysiol.00833.2002
Intramyocellular triacylglycerol in prolonged cycling with high- and low-carbohydrate availability
resolves10.1152/ajpendo.00159.2003
High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise
resolves10.1007/s001250051250
Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men
resolves10.2337/diabetes.50.11.2579
Effects of Intravenous and Dietary Lipid Challenge on Intramyocellular Lipid Content and the Relation With Insulin Sensitivity in Humans
resolves10.2337/diabetes.50.7.1612
Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects
resolves10.1152/ajpendo.00108.2002
Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men
resolves10.1152/japplphysiol.00304.2003
Intramyocellular lipid content is increased after exercise in nonexercising human skeletal muscle
resolves10.2337/diabetes.49.5.677
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
resolves10.2337/diabetes.51.7.2005
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
resolves10.1172/JCI5001
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
resolves10.2337/diabetes.48.6.1270
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
resolves10.1172/JCI25151
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
resolves10.1152/physrev.00024.2006
Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance
resolves10.1074/jbc.M200958200
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
resolves10.1002/hep.20466
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
resolves10.1111/j.1464-5491.2005.01582.x
Prevalence of non‐alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults
resolves10.2337/dc07-1463
Liver Fat Is Increased in Type 2 Diabetic Patients and Underestimated by Serum Alanine Aminotransferase Compared With Equally Obese Nondiabetic Subjects
resolves10.1053/jhep.2003.50161
Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome
resolves10.1097/01.mol.0000174153.53683.f2
Nonalcoholic fatty liver disease and the metabolic syndrome
resolves10.1002/hep.20302
Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice
resolves10.1074/jbc.M313478200
Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease
resolves10.1210/jc.2004-1983
Dietary Fat Content Modifies Liver Fat in Overweight Nondiabetic Subjects
resolves10.1016/j.freeradbiomed.2004.06.033
Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
resolves10.1051/rnd:2004033
n-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?
resolves10.1111/j.1365-2036.2006.02885.x
Prolonged n‐3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non‐alcoholic fatty liver disease: a pilot study
resolves10.1079/BJN20031079
Effects of dietary<i>n</i>-3 polyunsaturated fatty acids, breed and dietary vitamin E on the fatty acids of lamb muscle, liver and adipose tissue
resolves10.1172/JCI23621
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
resolves10.1210/jc.2004-2240
Plasma Adiponectin in Nonalcoholic Fatty Liver Is Related to Hepatic Insulin Resistance and Hepatic Fat Content, Not to Liver Disease Severity
resolves10.1172/JCI200317797
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
resolves10.1093/ajcn/77.1.43
Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
resolves10.1016/S0022-2275(20)32407-X
Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
resolves10.1079/BJN/2002544
Dietary carbohydrate's effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations
resolves10.1172/JCI118645
Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet.
resolves10.1074/jbc.274.42.30028
Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus
resolves10.1172/JCI119248
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
resolves10.1074/jbc.M201584200
Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lep/Lep Mice
resolves10.1002/mrm.20825
Hepatic lipid accumulation in healthy subjects: A comparative study using spectral fat‐selective MRI and volume‐localized <sup>1</sup>H‐MR spectroscopy
resolves10.1152/ajpendo.00064.2004
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
resolves10.2337/diabetes.52.3.701
Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content
resolves10.2337/diabetes.54.3.603
Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes
resolves10.1111/j.1365-2362.2007.01820.x
Lifestyle intervention in individuals with normal versus impaired glucose tolerance
resolves10.1210/jc.2006-2384
Effects of Diet-Induced Moderate Weight Reduction on Intrahepatic and Intramyocellular Triglycerides and Glucose Metabolism in Obese Subjects
resolves10.2337/diabetes.52.6.1364
Pioglitazone Reduces Hepatic Fat Content and Augments Splanchnic Glucose Uptake in Patients With Type 2 Diabetes
resolves10.1053/jhep.2003.50342
Cyp2e1 Activity Before and After Weight Loss in Morbidly Obese Subjects With Nonalcoholic Fatty Liver Disease
resolves10.1002/hep.510270121
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
resolves10.1016/0006-2952(81)90004-6
Hepatic microsomal ethanol oxidizing system (MEOS): Respective roles of ethanol and carbohydrates for the enhanced activity after chronic alcohol consumption
resolves10.1093/jn/121.7.959
Regulation of Hepatic Microsomal Cytochrome P450IIE1 Level by Dietary Lipids and Carbohydrates in Rats
resolves10.1172/JCI117936
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
resolves10.1053/jhep.2001.29628
Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
resolves10.1016/S0016-5085(99)70354-9
Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice
resolves10.1161/01.CIR.94.11.2837
Fatty Acid Oxidation Enzyme Gene Expression Is Downregulated in the Failing Heart
resolves10.1161/01.RES.0000154079.20681.B9
Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy
resolves10.1161/CIRCULATIONAHA.105.536318
Downregulation of Peroxisome Proliferator–Activated Receptor-α Gene Expression in a Mouse Model of Ischemic Cardiomyopathy Is Dependent on Reactive Oxygen Species and Prevents Lipotoxicity
resolves10.1073/pnas.0336724100
A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
resolves10.1074/jbc.M203458200
Overexpression of Apolipoprotein B in the Heart Impedes Cardiac Triglyceride Accumulation and Development of Cardiac Dysfunction in Diabetic Mice
resolves10.1172/JCI16751
Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
resolves10.1002/mrm.1910290203
Comparison of localized proton NMR signals of skeletal muscle and fat tissue <i>in vivo</i>: Two lipid compartments in muscle tissue
resolves10.1016/0730-725X(94)92543-7
Quantification of liver fat using magnetic resonance spectroscopy
resolves10.1002/mrm.10372
Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging
resolves10.1152/ajpendo.00095.2005
Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the method
resolves10.1210/jc.2006-0584
Myocardial Triglyceride Content and Epicardial Fat Mass in Human Obesity: Relationship to Left Ventricular Function and Serum Free Fatty Acid Levels
resolves10.2337/diabetes.49.3.399
Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.
resolves10.1073/pnas.91.23.10878
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.
resolves10.1007/s00247-005-1413-y
Obesity and fat quantification in lean tissues using three-point Dixon MR imaging
resolves10.1172/JCI420
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
resolves10.1210/jc.80.5.1584
Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
resolves10.1093/ilar.32.3.16
Zucker Diabetic Fatty Rat as a Model for Non-insulin-dependent Diabetes Mellitus
resolves10.2337/diabetes.53.11.2844
Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet
resolves10.1210/en.140.9.4005
Glucose-Induced Preproinsulin Gene Expression Is Inhibited by the Free Fatty Acid Palmitate
resolves10.2337/diabetes.50.4.803
Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?
resolves10.1074/jbc.273.47.31395
Long Chain Coenzyme A Esters Activate the Pore-forming Subunit (Kir6.2) of the ATP-regulated Potassium Channel
resolves10.1007/s001250050783
Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9)
resolves10.1210/en.2003-0410
Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death
resolves10.2337/diabetes.52.3.726
Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function
resolves10.2337/diabetes.46.12.2022
Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
The 5 references without a DOI — listed, not checked
no DOI — not checkedEffect of physical exercise on sensitivity and responsiveness to insulin in humans
no DOI — not checked10.1016/j.physbeh.2007.11.049_bib80
no DOI — not checkedInduction of cytochrome P450IIE1 in the obese overfed rat
no DOI — not checkedTumor necrosis factors: developments during the last decade
no DOI — not checked10.1016/j.physbeh.2007.11.049_bib122
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