Reference health
The role of 20-HETE in androgen-mediated hypertension
1 of 120 checkable references need attention · checked 2026-07-23
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
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References needing attention
marked retracted — notice via Crossref, record curated by Retraction Watch10.1210/jc.2007-0425
Withdrawn: Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measurements at High Risk for Worsening Cardiovascular Event-Free Survival: Results from the National Institutes of Health—National Heart, Lung, and Blood Institute Sponsored Women’s Ischemia Syndrome Evaluation
The 119 checked references that resolve
resolves10.1016/j.amjmed.2008.04.026
Sex Differences in Environmental and Genetic Factors for Hypertension
resolves10.1161/01.HYP.0000124670.03674.15
Novel Mechanisms Responsible for Postmenopausal Hypertension
resolves10.1016/0024-3205(91)90428-E
Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent
resolves10.1161/01.HYP.35.1.480
Gender Differences in Development of Hypertension in Spontaneously Hypertensive Rats
resolves10.1161/01.HYP.31.1.435
Testosterone Exacerbates Hypertension and Reduces Pressure-Natriuresis in Male Spontaneously Hypertensive Rats
resolves10.1097/00004872-199310000-00005
Role of vasopressin, the renin???angiotensin system and sex in Dahl salt-sensitive hypertension
resolves10.1161/01.HYP.29.1.494
Gonadal Hormones Modulate Deoxycorticosterone-Salt Hypertension in Male and Female Rats
resolves10.1161/01.HYP.9.2.172
Sex difference in the development of deoxycorticosterone-salt hypertension in the rat.
resolves10.1530/acta.0.1240091
Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive rats
resolves10.1073/pnas.081627898
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension
resolves10.1016/0895-7061(95)00216-2
24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender*
resolves10.1161/01.HYP.0000112224.87290.3a
20-HETE and Circulating Insulin in Essential Hypertension With Obesity
resolves10.1016/j.diabres.2006.04.001
20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans
resolves10.1016/j.amjcard.2010.05.013
Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids, Blood Pressure, Left Ventricular Dimensions, and Rhythm
resolves10.1136/hrt.2003.015719
Are the cardiac effects of anabolic steroid abuse in strength athletes reversible?
resolves10.1530/EJE-10-0951
Metabolic syndrome and the effect of testosterone treatment in young men with congenital hypogonadotropic hypogonadism
resolves10.1210/jc.2005-1398
Vascular Reactivity in Congenital Hypogonadal Men before and after Testosterone Replacement Therapy
resolves10.1111/j.1447-0756.2008.00857.x
Increased arterial stiffness in female‐to‐male transsexuals treated with androgen
resolves10.1097/FJC.0b013e3181f04b1c
20-Hydroxyeicosatetraeonic Acid: A New Target for the Treatment of Hypertension
resolves10.1161/HYPERTENSIONAHA.107.089599
Vascular Cytochrome P450 4A Expression and 20-Hydroxyeicosatetraenoic Acid Synthesis Contribute to Endothelial Dysfunction in Androgen-Induced Hypertension
resolves10.1161/HYPERTENSIONAHA.110.161570
Androgen-Dependent Hypertension Is Mediated by 20-Hydroxy-5,8,11,14-Eicosatetraenoic Acid–Induced Vascular Dysfunction
resolves10.1152/ajpregu.00459.2002
Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension
resolves10.1080/03602530701468573
Human Cytochrome P450 Family 4 Enzymes: Function, Genetic Variation and Regulation
resolves10.1146/annurev.pharmtox.45.120403.100045
REGULATION AND INHIBITION OF ARACHIDONIC ACID ω-HYDROXYLASES AND 20-HETE FORMATION
resolves10.1016/j.bcp.2008.03.004
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases
resolves10.1016/j.pharmthera.2006.03.008
Cytochrome P450 4F subfamily: At the crossroads of eicosanoid and drug metabolism
resolves10.1074/jbc.275.6.4118
Formation of 20-Hydroxyeicosatetraenoic Acid, a Vasoactive and Natriuretic Eicosanoid, in Human Kidney
resolves10.1161/01.CIR.0000151309.82473.59
Functional Variant of
<i>CYP4A11</i>
20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension
resolves10.1124/jpet.103.059626
Catalytic Activity and Isoform-Specific Inhibition of Rat Cytochrome P450 4F Enzymes
resolves10.1042/BJ20061328
Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation
resolves10.1152/ajprenal.00132.2002
Distribution of cytochrome<i>P</i>-450 4A and 4F isoforms along the nephron in mice
resolves10.1152/physrev.00021.2001
<i>P</i>-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function
resolves10.1016/j.freeradbiomed.2007.03.004
A reduction in alcohol consumption is associated with reduced plasma F2-isoprostanes and urinary 20-HETE excretion in men
resolves10.1016/j.freeradbiomed.2004.12.024
Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects
resolves10.1161/01.CIR.0000136808.72912.D9
Urinary 20-Hydroxyeicosatetraenoic Acid Is Associated With Endothelial Dysfunction in Humans
resolves10.1681/ASN.2007060713
Association of a Functional Cytochrome P450 4F2 Haplotype with Urinary 20-HETE and Hypertension
resolves10.1161/HYPERTENSIONAHA.107.104463
A Single Nucleotide Polymorphism in the
<i>CYP4F2</i>
but not
<i>CYP4A11</i>
Gene Is Associated With Increased 20-HETE Excretion and Blood Pressure
resolves10.1161/HYPERTENSIONAHA.108.114199
The V433M Variant of the
<i>CYP4F2</i>
Is Associated With Ischemic Stroke in Male Swedes Beyond Its Effect on Blood Pressure
resolves10.1182/blood.V78.6.1461.1461
Modulation of erythropoiesis by novel human bone marrow cytochrome P450- dependent metabolites of arachidonic acid
resolves10.1002/bms.1200210505
Quantitation of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) produced by human polymorphonuclear leukocytes using electron capture ionization gas chromatography/mass spectrometry
resolves10.1152/japplphysiol.01159.2001
CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium
resolves10.1152/ajprenal.00265.2001
Cytochrome<i>P</i>-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries
resolves10.1016/S0022-3565(25)23636-9
Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase.
resolves10.1161/CIRCRESAHA.108.193227
Synergistic Activation of Vascular TRPC6 Channel by Receptor and Mechanical Stimulation via Phospholipase C/Diacylglycerol and Phospholipase A
<sub>2</sub>
/ω-Hydroxylase/20-HETE Pathways
resolves10.1161/01.HYP.0000047240.33861.6B
20-HETE–Induced Contraction of Small Coronary Arteries Depends on the Activation of Rho-Kinase
resolves10.1152/ajprenal.00249.2002
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries
resolves10.1152/ajpregu.2001.280.1.R255
CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR
resolves10.1152/ajpheart.00627.2003
Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli
resolves10.1161/hy1201.096116
Modulation by 20-HETE of Phenylephrine-Induced Mesenteric Artery Contraction in Spontaneously Hypertensive and Wistar-Kyoto Rats
resolves10.1161/01.HYP.22.3.357
Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450.
resolves10.1152/ajprenal.00364.2009
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE
resolves10.1161/01.RES.87.10.840
Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress
resolves10.1152/ajpheart.2000.278.5.H1517
Contribution of cytochrome<i>P</i>-450 ω-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension
resolves10.1152/japplphysiol.00247.2002
Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries
resolves10.1152/ajplung.00424.2005
Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells
resolves10.1161/01.RES.0000217283.98806.a6
Endothelial Dysfunction and Hypertension in Rats Transduced With CYP4A2 Adenovirus
resolves10.1152/ajpheart.01172.2007
20-Hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling
resolves10.1124/jpet.109.159863
20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Mediates Endothelial Dysfunction via IκB Kinase-Dependent Endothelial Nitric-Oxide Synthase Uncoupling
resolves10.1111/j.1440-1681.2011.05509.x
Chronic activation of AMP‐activated protein kinase prevents 20‐hydroxyeicosatetraenoic acid‐induced endothelial dysfunction
resolves10.1152/ajpheart.00512.2008
Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats
resolves10.1097/00004872-200502000-00002
Small artery structure and hypertension: adaptive changes and target organ damage
resolves10.1016/j.amjhyper.2004.05.023
Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment
resolves10.1161/01.CIR.0000089190.95415.9F
New Markers of Inflammation and Endothelial Cell Activation
resolves10.1084/jem.20070657
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
resolves10.1161/HYPERTENSIONAHA.108.112706
Role of Inflammation in the Development of Renal Damage and Dysfunction in Angiotensin II–Induced Hypertension
resolves10.1152/japplphysiol.90470.2008
Inflammation and endothelial dysfunction during aging: role of NF-κB
resolves10.1152/ajpheart.01346.2006
Increased mitochondrial H<sub>2</sub>O<sub>2</sub> production promotes endothelial NF-κB activation in aged rat arteries
resolves10.1016/j.exger.2006.04.005
Amelioration of age-related inflammation and oxidative stress by PPARγ activator: Suppression of NF-κB by 2,4-thiazolidinedione
resolves10.1161/01.RES.0000269183.13937.e8
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans
resolves10.1042/CS20060247
Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions
resolves10.1186/1471-2261-2-3
Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
resolves10.1161/CIRCRESAHA.107.150474
Vascular Endothelial Cell–Specific NF-κB Suppression Attenuates Hypertension-Induced Renal Damage
resolves10.1124/jpet.107.130336
20-Hydroxyeicosatetraenoic Acid Stimulates Nuclear Factor-κB Activation and the Production of Inflammatory Cytokines in Human Endothelial Cells
resolves10.1124/jpet.106.115360
Activation of Vascular Endothelial Growth Factor through Reactive Oxygen Species Mediates 20-Hydroxyeicosatetraenoic Acid-Induced Endothelial Cell Proliferation
resolves10.1152/ajplung.00278.2007
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells
resolves10.1152/ajpheart.00874.2008
20-HETE can act as a nonhypoxic regulator of HIF-1α in human microvascular endothelial cells
resolves10.1046/j.1523-1755.2000.057003863.x
Understanding hypertension through genetic manipulation in mice
resolves10.1152/ajpregu.00664.2001
Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II
resolves10.1152/ajpregu.00401.2005
Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE
resolves10.1016/j.vph.2007.05.005
Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats
resolves10.1161/01.HYP.37.2.623
20-Hydroxyeicosatetraenoic Acid Mediates Angiotensin II–Induced Phospholipase D Activation in Vascular Smooth Muscle Cells
resolves10.1161/01.HYP.0000168051.04275.ea
Contribution of Arachidonic Acid Metabolites Derived Via Cytochrome P4504A to Angiotensin II–Induced Neointimal Growth
resolves10.1161/HYPERTENSIONAHA.110.154559
CYP4A2-Induced Hypertension Is 20-Hydroxyeicosatetraenoic Acid– and Angiotensin II–Dependent
resolves10.1126/science.2492116
Treatment with Tin Prevents the Development of Hypertension in Spontaneously Hypertensive Rats
resolves10.1258/ebm.2010.009233
Renal function and vasomotor activity in mice lacking the Cyp4a14 gene
resolves10.1016/j.pharmthera.2009.12.002
Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases
resolves10.1161/HYPERTENSIONAHA.107.102921
The T8590C Polymorphism of CYP4A11 and 20-Hydroxyeicosatetraenoic Acid in Essential Hypertension
resolves10.1038/ajh.2008.276
A Haplotype of the CYP4F2 Gene is Associated With Cerebral Infarction in Japanese Men
resolves10.1291/hypres.31.1719
Haplotype-Based Case-Control Study of the Human CYP4F2 Gene and Essential Hypertension in Japanese Subjects
resolves10.1016/j.ymgme.2008.11.161
A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men
resolves10.1097/01.hjh.0000244944.34546.8e
Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction
resolves10.1097/HJH.0b013e3282f2f10c
A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men
resolves10.1152/physiolgenomics.00003.2007
Functional polymorphism in human CYP4F2 decreases 20-HETE production
resolves10.1097/HJH.0b013e328342673c
Peripheral and central augmentation indexes in relation to the CYP4F2 polymorphisms in Chinese
resolves10.1073/pnas.95.21.12701
20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells
The 5 references without a DOI — listed, not checked
no DOI — not checkedRenal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension
no DOI — not checkedThe effect of gender on age-related blood pressure changes and the prevalence of isolated systolic hypertension among older adults: data from NHANES III
no DOI — not checkedJi H, Zheng W, Wu X, et al. Sex chromosome effects unmasked in angiotensin II-induced hypertension. Hypertension.
no DOI — not checkedKinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors
no DOI — not checked20-HETE is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles
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