Reference health
The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism
17/17 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
13 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 17 checked references that resolve
resolves10.1016/S0140-6736(94)90127-9
Anti-inflammatory effects of low-dose oral theophylline in atopic asthma
resolves10.1006/pulp.1994.1001
Inhibitors of Cyclic Nucleotide Phosphodiesterase Isoenzymes—their Potential Utility in the Therapy of Asthma
resolves10.1073/pnas.132556899
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
resolves10.1164/rccm.200906-0937OC
Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease
resolves10.1136/thorax.55.10.837
Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice
resolves10.1183/09031936.97.10122754
Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma
resolves10.1001/archinte.1994.00420120066007
Comparison of Patients' Compliance With Prescribed Oral and Inhaled Asthma Medications
resolves10.1002/jlb.67.4.529
Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism
resolves10.1185/030079901750120196
Doxofylline: A New Generation Xanthine Bronchodilator Devoid of Major Cardiovascular Adverse Effects
resolves10.1016/S0140-6736(09)61252-6
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
resolves10.1016/S0140-6736(09)61255-1
Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
resolves10.1016/0014-2999(89)90721-8
Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF
resolves10.1111/j.1365-2036.1990.tb00512.x
The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients
resolves10.1016/j.bbrc.2005.10.159
Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells
The 13 references without a DOI — listed, not checked
no DOI — not checked10.1016/j.pupt.2011.10.007_bib6
no DOI — not checkedGOLD - Global Initiative for chronic obstructive lung disease. Executive summary. Based on an April 1998 NHLBI/WHO Workshop, Updated 2004. Available at: http://www.goldcopd.com/. Accessed January 17, 2006.
no DOI — not checkedPharmacology of anti-asthma xanthines
no DOI — not checkedComparative effects of bamifylline and theophylline on allergic bronchospasm induced by the proactive inhalation test: a double-blind cross-over study
no DOI — not checkedAcebrofylline: an airway regulator and anti-inflammatory agent
no DOI — not checkedDoxofylline, an anti-asthmatic drug lacking affinity for adenosine receptors
no DOI — not checkedTreatment of reversible chronic airways obstruction with doxofylline compared with slow-release theophylline: a double-blind, randomized, multicentre trial
no DOI — not checkedClinical evaluation of doxofylline sachets in a pediatric population
no DOI — not checkedEfficacy and safety of doxofylline compared to theophylline in chronic reversible asthma - a double blind, randomized, placebo-controlled multicentre clinical trial
no DOI — not checkedDoxofylline differs from methylxanthines in its movement of cytosolic calcium
no DOI — not checkedEffects of theophylline and doxofylline on airway responsiveness in dogs
no DOI — not checkedEffect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils
no DOI — not checkedChronotropic and arrhythmogenic effects of two methylxanthine bronchodilators, doxofylline and theophylline, evaluated by Holter monitoring
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