Reference health
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition
79/79 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
17 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 79 checked references that resolve
resolves10.1016/j.yrtph.2013.03.001
Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation
resolves10.1093/ilar/ilw026
Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs
resolves10.14573/altex.2011.4.273
How are reproductive toxicity and developmental toxicity addressed in REACH dossiers?
resolves10.1093/toxsci/kfu234
FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology
resolves10.1080/10408444.2016.1224807
Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects
resolves10.1016/j.reprotox.2016.05.005
Computational modeling and simulation of genital tubercle development
resolves10.1371/journal.pcbi.1002996
A Computational Model Predicting Disruption of Blood Vessel Development
resolves10.1039/C6TX00083E
QSAR modeling for predicting reproductive toxicity of chemicals in rats for regulatory purposes
resolves10.1080/15376510701857320
In Silico Tools for Sharing Data and Knowledge on Toxicity and Metabolism: Derek for Windows, Meteor, and Vitic
resolves10.1002/etc.34
Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment
resolves10.1177/026119291604400515
The Adverse Outcome Pathway for Skin Sensitisation: Moving Closer to Replacing Animal Testing
resolves10.1016/j.tox.2013.08.011
The adverse outcome pathway concept: A pragmatic tool in toxicology
resolves10.1016/j.drudis.2013.05.015
The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality
resolves10.1016/j.reprotox.2014.10.008
An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis
resolves10.1093/toxsci/kfw207
How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology
resolves10.1210/er.2008-0016
History of Aromatase: Saga of an Important Biological Mediator and Therapeutic Target
resolves10.1016/S0039-128X(99)00104-X
Aromatase inhibitors and their application in breast cancer treatmentâ
resolves10.1016/j.fertnstert.2006.03.014
Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate
resolves10.1016/j.yrtph.2015.04.004
Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence
resolves10.1002/minf.201600154
A Semi-automated Approach to Create Purposeful Mechanistic Datasets from Heterogeneous Data: Data Mining Towards the <i>in silico</i>
Predictions for Oestrogen Receptor Modulation and Teratogenicity
resolves10.1021/ci100176x
Trust, But Verify: On the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research
resolves10.1080/10629360902949567
How not to develop a quantitative structure–activity or structure–property relationship (QSAR/QSPR)
resolves10.1021/acs.chemrestox.7b00037
In Silico Prediction of Chemicals Binding to Aromatase with Machine Learning Methods
resolves10.1093/mutage/gey034
Important considerations for the validation of QSAR models for <i>in vitro</i> mutagenicity
resolves10.1111/j.1742-1241.2007.01587.x
The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer
resolves10.1210/endo-86-6-1245
Production of Congenital Lipoid Adrenal Hyperplasia in Rats and Inhibition of Cholesterol Side-Chain Cleavage
resolves10.2527/jas1976.421131x
Gestation Length in Rabbits—Effect of Aminoglutethimide Phosphate, Dexamethasone, Pregnenolone and Progesterone
resolves10.2131/jts.34.S91
Collaborative work on evaluation of ovarian toxicity 8) Two- or four-week repeated-dose studies and fertility study of Anastrozole in female rats
resolves10.1677/joe.0.1640225
Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility
resolves10.1016/S0890-6238(01)00120-4
Reproductive toxicity of exemestane, an antitumoral aromatase inactivator, in rats and rabbits
resolves10.1016/S0960-0760(97)80008-8
Effect of estrogen deprivation on the reproductive physiology of male and female primates
resolves10.1677/joe.0.1800337
The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats
resolves10.1016/0890-6238(96)00083-4
Recovery of reproductive function in rats treated with the aromatase inhibitor fadrozole
resolves10.1093/humrep/den100
Effects of the aromatase inhibitor letrozole on in utero development in rats
resolves10.1093/humrep/dep277
Impact of estrogen replacement on letrozole-induced embryopathic effects
resolves10.1210/endo-104-1-118
Antifertility Effects of an Aromatase Inhibitor, 1,4,6-Androstatriene-3,17-Dione*
resolves10.1016/S0039-128X(98)00042-7
Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata)
resolves10.1016/j.bmcl.2005.01.044
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs)
resolves10.1021/tx400226u
Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants
resolves10.1007/s00204-020-02834-y
Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals
resolves10.1073/pnas.96.14.7986
Impairment of spermatogenesis in mice lacking a functional aromatase (
<i>cyp 19</i>
) gene
resolves10.1186/1477-7827-1-57
The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy
resolves10.1056/NEJM199707103370204
Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency
resolves10.3390/ijms18050904
Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction
resolves10.1530/ror.0.0050084
Oestrogen in fluid transport in efferent ducts of the male reproductive tract
resolves10.1210/jc.2005-0982
Comparative Assessment in Young and Elderly Men of the Gonadotropin Response to Aromatase Inhibition
resolves10.1210/en.2008-1016
Estrogen-Dependent and -Independent Estrogen Receptor-α Signaling Separately Regulate Male Fertility
resolves10.1093/humupd/dmg034
Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men
resolves10.1002/jat.2949
New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis
resolves10.1002/jat.2984
Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence
resolves10.1016/j.yrtph.2017.02.017
Quantitative weight of evidence to assess confidence in potential modes of action
resolves10.3390/molecules25030739
Towards an Understanding of the Mode of Action of Human Aromatase Activity for Azoles through Quantum Chemical Descriptors-Based Regression and Structure Activity Relationship Modeling Analysis
resolves10.1093/toxres/tfaa099
Beyond adverse outcome pathways: making toxicity predictions from event networks, SAR models, data and knowledge
resolves10.1007/s11356-009-0285-3
Assessment of chemical effects on aromatase activity using the H295R cell line
The 17 references without a DOI — listed, not checked
no DOI — not checkedVEGA-QSAR: AI inside a platform for predictive toxicology
no DOI — not checkedKNIME - the konstanz information miner
no DOI — not checkedCurrent evidence supporting “letrozole” for ovulation induction
no DOI — not checkedPart 3: health hazards
no DOI — not checkedGuidance for industry
no DOI — not checkedMale reproductive system
no DOI — not checkedAminoglutethimide: a possible cause of pseudohermaphroditism in females
no DOI — not checked10.1016/j.reprotox.2022.01.004_bib0245
no DOI — not checked10.1016/j.reprotox.2022.01.004_bib0280
no DOI — not checkedMead Johnson, TESLAC (testolactone tablets, USP), (n.d.). https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/16118slr023_teslac_lbl.pdf.
no DOI — not checkedOECD, OECD QSAR Toolbox, (n.d.). https://qsartoolbox.org/.
no DOI — not checkedAdverse outcome pathways for developmental toxicity
no DOI — not checked10.1016/j.reprotox.2022.01.004_bib0335
no DOI — not checked10.1016/j.reprotox.2022.01.004_bib0340
no DOI — not checkedInhibition of estrogen biosynthesis and its consequences on gonadotrophin secretion in the male, J. Steroid Biochem
no DOI — not checkedOpen dose-finding study of a new potent and selective nonsteroidal aromatase inhibitor, CGS 20 267, in healthy male subjects
no DOI — not checkedHistopathologic effects of anastrozole an aromatase enzyme inhibitor on rat testicles, Turkiye Klin
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