Reference health
The surprising complexity of signal sequences
1 of 79 checkable references need attention · checked 2026-07-22
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
References needing attention
marked retracted — notice via Crossref, record curated by Retraction Watch10.1038/sj.embor.7400551
L25 functions as a conserved ribosomal docking site shared by nascent chain‐associated complex and signal‐recognition particle
The 78 checked references that resolve
resolves10.1083/jcb.67.3.835
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.
resolves10.1073/pnas.77.6.3369
Eukaryotic signal sequence transports insulin antigen in Escherichia coli.
resolves10.1016/S0021-9258(18)33642-1
A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum.
resolves10.1126/science.3541205
Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase
resolves10.1002/j.1460-2075.1985.tb04164.x
Analysis of signals for secretion in the staphylococcal protein A gene.
resolves10.1073/pnas.77.12.7112
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.
resolves10.1083/jcb.102.5.1543
Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis.
resolves10.1016/0092-8674(83)90352-5
Translocation of domains of nascent periplasmic proteins across the cytoplasmic membrane is independent of elongation
resolves10.1126/science.1701272
An
<i>E. coli</i>
Ribonucleoprotein Containing 4.5
<i>S</i>
RNA Resembles Mammalian Signal Recognition Particle
resolves10.1016/S0092-8674(00)81839-5
The E. coli Signal Recognition Particle Is Required for the Insertion of a Subset of Inner Membrane Proteins
resolves10.1016/S0092-8674(00)81418-X
Crystal Structure of the Signal Sequence Binding Subunit of the Signal Recognition Particle
resolves10.1126/science.287.5456.1232
Crystal Structure of the Ribonucleoprotein Core of the Signal Recognition Particle
resolves10.1074/jbc.M309082200
Basic Amino Acids in a Distinct Subset of Signal Peptides Promote Interaction with the Signal Recognition Particle
resolves10.1083/jcb.134.2.269
Signal sequences specify the targeting route to the endoplasmic reticulum membrane.
resolves10.1073/pnas.95.25.14646
Differential use of the signal recognition particle translocase targeting pathway for inner membrane protein assembly in
<i>Escherichia coli</i>
resolves10.1073/pnas.051484198
The targeting pathway of
<i>Escherichia coli</i>
presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal
resolves10.1128/JB.187.9.2983-2991.2005
Use of Thioredoxin as a Reporter To Identify a Subset of
<i>Escherichia coli</i>
Signal Sequences That Promote Signal Recognition Particle-Dependent Translocation
resolves10.1083/jcb.200407082
N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning
resolves10.1093/emboj/18.20.5494
Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP‐dependent phosphorylation at Ser128
resolves10.1016/0092-8674(95)90313-5
A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane
resolves10.1016/S0092-8674(00)81738-9
Signal Sequence Recognition in Posttranslational Protein Transport across the Yeast ER Membrane
resolves10.1038/nature03821
A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum
resolves10.1038/nature03670
Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1
resolves10.1083/jcb.134.1.25
Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane.
resolves10.1083/jcb.200210095
Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane
resolves10.1016/S0092-8674(00)81861-9
Binding of Secretory Precursor Polypeptides to a Translocon Subcomplex Is Regulated by BiP
resolves10.1091/mbc.10.2.329
Detection of Transient In Vivo Interactions between Substrate and Transporter during Protein Translocation into the Endoplasmic Reticulum
resolves10.1016/S1534-5807(01)00120-4
Signal Sequences Control Gating of the Protein Translocation Channel in a Substrate-Specific Manner
resolves10.1016/j.devcel.2005.09.001
Regulation of Protein Compartmentalization Expands the Diversity of Protein Function
resolves10.1083/jcb.106.4.1093
Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm.
resolves10.1128/JVI.63.12.5238-5243.1989
Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide
resolves10.1128/JVI.71.1.345-353.1997
Posttranscriptional regulation of hepatitis B virus replication by the precore protein
resolves10.1126/science.1073725
Neurotoxicity and Neurodegeneration When PrP Accumulates in the Cytosol
resolves10.1126/science.279.5352.827
A Transmembrane Form of the Prion Protein in Neurodegenerative Disease
resolves10.1091/mbc.E02-05-0293
Cotranslational Partitioning of Nascent Prion Protein into Multiple Populations at the Translocation Channel
resolves10.1038/sj.emboj.7600462
Protection from cytosolic prion protein toxicity by modulation of protein translocation
resolves10.1073/pnas.0406055102
An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter
resolves10.1074/jbc.M302117200
Signal Sequences Initiate the Pathway of Maturation in the Endoplasmic Reticulum Lumen
resolves10.1093/emboj/20.7.1573
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor
resolves10.1074/jbc.M007723200
Signal Peptidase and Oligosaccharyltransferase Interact in a Sequential and Dependent Manner within the Endoplasmic Reticulum
resolves10.1073/pnas.93.18.9606
Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport.
resolves10.1074/jbc.M002373200
The Long Signal Peptide Isoform and Its Alternative Processing Direct the Intracellular Trafficking of Interleukin-15
resolves10.1128/JB.185.9.2910-2919.2003
The YSIRK-G/S Motif of Staphylococcal Protein A and Its Role in Efficiency of Signal Peptide Processing
resolves10.1016/S0021-9258(18)33964-4
Prolipoprotein signal peptidase in Escherichia coli is distinct from the M13 procoat protein signal peptidase.
resolves10.1073/pnas.88.8.3281
Product of the Pseudomonas aeruginosa gene pilD is a prepilin leader peptidase.
resolves10.1126/science.1070925
Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease
resolves10.1016/S1097-2765(02)00655-X
Requirements for Signal Peptide Peptidase-Catalyzed Intramembrane Proteolysis
resolves10.1002/eji.1830270517
The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9
resolves10.1084/jem.187.5.813
Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis
resolves10.1126/science.287.5455.1031
Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40
resolves10.4049/jimmunol.164.10.5019
Cutting Edge: The Human Cytomegalovirus <i>UL40</i> Gene Product Contains a Ligand for HLA-E and Prevents NK Cell-Mediated Lysis
resolves10.1093/emboj/16.22.6636
Signal peptide fragments of preprolactin and HIV‐1 p‐gp160 interact with calmodulin
resolves10.1128/JVI.75.13.5762-5771.2001
A Particle-Associated Glycoprotein Signal Peptide Essential for Virus Maturation and Infectivity
resolves10.1074/jbc.M302343200
Long-lived Signal Peptide of Lymphocytic Choriomeningitis Virus Glycoprotein pGP-C
resolves10.1038/sj.embor.7400002
Identification of Lassa virus glycoprotein signal peptide as a trans‐acting maturation factor
resolves10.1091/mbc.E04-06-0508
The Efficiency of Protein Compartmentalization into the Secretory Pathway
resolves10.1016/0092-8674(95)90077-2
Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p
resolves10.1002/j.1460-2075.1996.tb00492.x
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.
resolves10.1091/mbc.01-10-0518
Recognition of a Subset of Signal Sequences by Ssh1p, a Sec61p-related Protein in the Membrane of Endoplasmic Reticulum of Yeast<i>Saccharomyces cerevisiae</i>
resolves10.1093/glycob/cwj026
Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons
resolves10.1073/pnas.97.13.7214
Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes
resolves10.1093/emboj/16.10.2756
Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme
resolves10.1046/j.1365-2958.2003.03346.x
Versatility of inner membrane protein biogenesis in <i>Escherichia coli</i>
resolves10.1111/j.1365-2958.2005.04919.x
Determinants of the streptococcal surface glycoprotein GspB that facilitate export by the accessory Sec system
resolves10.1074/jbc.M411716200
Secretion of Cartilage Oligomeric Matrix Protein Is Affected by the Signal Peptide
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