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Life is 3D: Boosting Spheroid Function for Tissue Engineering
84/84 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
4 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 84 checked references that resolve
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Engineering Three-Dimensional Stem Cell Morphogenesis for the Development of Tissue Models and Scalable Regenerative Therapeutics
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Advances in the formation, use and understanding of multi-cellular spheroids
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Enhanced Cartilage Formation via Three-Dimensional Cell Engineering of Human Adipose-Derived Stem Cells
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Fibroblasts maintained in 3 dimensions show a better differentiation state and higher sensitivity to estrogens
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Rapid formation of size-controlled three dimensional hetero-cell aggregates using micro-rotation flow for spheroid study
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Sphere formation of adipose stem cell engineered by poly-2-hydroxyethyl methacrylate induces in vitro angiogenesis through fibroblast growth factor 2
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Fabrication of multi‐well chips for spheroid cultures and implantable constructs through rapid prototyping techniques
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On the relation between size of necrosis and diameter of tumor spheroids
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High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
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A novel hanging spherical drop system for the generation of cellular spheroids and high throughput combinatorial drug screening
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Hydrogel Thin Film with Swelling-Induced Wrinkling Patterns for High-Throughput Generation of Multicellular Spheroids
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A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells
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The effects of spheroid formation of adipose-derived stem cells in a microgravity bioreactor on stemness properties and therapeutic potential
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Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids
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Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells
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Therapeutic Potential of Human Adipose-Derived Stem/Stromal Cell Microspheroids Prepared by Three-Dimensional Culture in Non-Cross-Linked Hyaluronic Acid Gel
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Conditioned medium of adipose-derived stromal cell culture in three-dimensional bioreactors for enhanced wound healing
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Use of Culture Geometry to Control Hypoxia-Induced Vascular Endothelial Growth Factor Secretion from Adipose-Derived Stem Cells: Optimizing a Cell-Based Approach to Drive Vascular Growth
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Three-dimensional spheroids of adipose-derived mesenchymal stem cells are potent initiators of blood vessel formation in porous polyurethane scaffolds
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Self‐assembled adult adipose‐derived stem cell spheroids combined with biomaterials promote wound healing in a rat skin repair model
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Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties
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Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self‐activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti‐inflammatory Phenotype
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3D spheroid culture enhances survival and therapeutic capacities of <scp>MSC</scp>s injected into ischemic kidney
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Artificial Islets From Hybrid Spheroids of Three Pancreatic Cell Lines
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Transplantation of Heterospheroids of Islet Cells and Mesenchymal Stem Cells for Effective Angiogenesis and Antiapoptosis
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Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance
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The Effect of Three-Dimensional Co-Culture of Hepatocytes and Hepatic Stellate Cells on Key Hepatocyte Functions in vitro
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Three‐dimensional Co‐culture of hepatic progenitor cells and mesenchymal stem cells in vitro and in vivo
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3D co-culturing model of primary pancreatic islets and hepatocytes in hybrid spheroid to overcome pancreatic cell shortage
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Hybrid Cellular Spheroids From Hepatocellular Carcinoma and Insulin-Secreting Cell Lines
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Generation of co-culture spheroids as vascularisation units for bone tissue engineering
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In Vitro Analysis of Scaffold-free Prevascularized Microtissue Spheroids Containing Human Dental Pulp Cells and Endothelial Cells
resolves10.1016/j.actbio.2014.06.035
In vitro osteogenic differentiation of adipose-derived mesenchymal stem cell spheroids impairs their in vivo vascularization capacity inside implanted porous polyurethane scaffolds
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Physiologically Low Oxygen Enhances Biomolecule Production and Stemness of Mesenchymal Stem Cell Spheroids
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Hypoxia combined with spheroid culture improves cartilage specific function in chondrocytes
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An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids
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Media additives to promote spheroid circularity and compactness in hanging drop platform
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Normal atmospheric oxygen tension and the use of antioxidants improve hepatocyte spheroid viability and function
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Use of biomimetic microtissue spheroids and specific growth factor supplementation to improve tenocyte differentiation and adaptation to a collagen-based scaffold in vitro
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Enhanced Chondrogenic Differentiation Potential of Human Gingival Fibroblasts by Spheroid Formation on Chitosan Membranes
resolves10.1016/j.biomaterials.2013.03.031
Substrate-dependent Wnt signaling in MSC differentiation within biomaterial-derived 3D spheroids
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Substrate-dependent gene regulation of self-assembled human MSC spheroids on chitosan membranes
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Switchable Water‐Adhesive, Superhydrophobic Palladium‐Layered Silicon Nanowires Potentiate the Angiogenic Efficacy of Human Stem Cell Spheroids
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Modulation of Huh7.5 Spheroid Formation and Functionality Using Modified PEG-Based Hydrogels of Different Stiffness
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Silicon Nanowire-Induced Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
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Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation
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Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential
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Soft Elasticity-Associated Signaling and Bone Morphogenic Protein 2 Are Key Regulators of Mesenchymal Stem Cell Spheroidal Aggregates
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Substrate-mediated nanoparticle/gene delivery to MSC spheroids and their applications in peripheral nerve regeneration
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Schwann cells: Origins and role in axonal maintenance and regeneration
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Solid freeform-fabricated scaffolds designed to carry multicellular mesenchymal stem cell spheroids for cartilage regeneration
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Formation of Human Fibroblast Aggregates (Spheroids) by Rotational Culture
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Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs
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In vitro characterization of self-assembled anterior cruciate ligament cell spheroids for ligament tissue engineering
resolves10.1016/j.biomaterials.2015.08.037
In-situ birth of MSCs multicellular spheroids in poly(l-glutamic acid)/chitosan scaffold for hyaline-like cartilage regeneration
resolves10.1007/s10856-015-5591-3
Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids
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A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells
resolves10.4081/ejh.2013.e31
Three-dimensional scaffold-free fusion culture: the way to enhance chondrogenesis of in vitro propagated human articular chondrocytes
resolves10.1016/j.jbiosc.2015.12.019
Formation of three-dimensional hepatic tissue by the bottom-up method using spheroids
resolves10.1186/s13018-014-0098-z
Simultaneous regeneration of full-thickness cartilage and subchondral bone defects in vivo using a three-dimensional scaffold-free autologous construct derived from high-density bone marrow-derived mesenchymal stem cells
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Scaffold-free vascular tissue engineering using bioprinting
resolves10.1002/adhm.201200408
Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening
resolves10.1016/j.actbio.2014.11.024
Manipulation of cellular spheroid composition and the effects on vascular tissue fusion
resolves10.1016/j.actbio.2013.10.021
Biological magnetic cellular spheroids as building blocks for tissue engineering
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Janus magnetic cellular spheroids for vascular tissue engineering
The 4 references without a DOI — listed, not checked
no DOI — not checkedThree-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures
no DOI — not checkedBrain-derived neurotrophic factor: three ligands, many actions
no DOI — not checkedSelf-assembly of tissue spheroids on polymeric membranes
no DOI — not checkedBio-Pick
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