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Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives

https://doi.org/10.1016/s2666-7568(21)00086-6
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40/40 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 40 checked references that resolve
resolves10.1093/eurheartj/ehz962
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
resolves10.1016/j.jacc.2015.02.020
Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
resolves10.1093/eurheartj/eht571
Mendelian randomization of blood lipids for coronary heart disease
resolves10.1001/jama.2016.13985
Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions
resolves10.1001/jamacardio.2019.3780
Apolipoprotein B Particles and Cardiovascular Disease
resolves10.1161/CIRCOUTCOMES.110.959247
A Meta-Analysis of Low-Density Lipoprotein Cholesterol, Non-High-Density Lipoprotein Cholesterol, and Apolipoprotein B as Markers of Cardiovascular Risk
resolves10.1097/MOL.0000000000000330
The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity
resolves10.1001/jama.2017.11467
Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk
resolves10.1001/jama.2018.20045
Association of Triglyceride-Lowering <i>LPL</i> Variants and LDL-C–Lowering <i>LDLR</i> Variants With Risk of Coronary Heart Disease
resolves10.1371/journal.pmed.1003062
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
resolves10.1093/ije/dyy262
An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
resolves10.1093/ije/dym276
The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine
resolves10.1371/journal.pmed.1001779
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
resolves10.1038/s41586-018-0579-z
The UK Biobank resource with deep phenotyping and genomic data
resolves10.1038/s41467-019-11558-2
A meta-analysis of genome-wide association studies identifies multiple longevity genes
resolves10.1038/s41588-018-0241-6
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
resolves10.1038/ng.3190
Efficient Bayesian mixed-model analysis increases association power in large cohorts
resolves10.1038/s41588-018-0144-6
Mixed-model association for biobank-scale datasets
resolves10.1038/nature11632
An integrated map of genetic variation from 1,092 human genomes
resolves10.1002/gepi.21965
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
resolves10.1093/ije/dyx102
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
resolves10.1093/ije/dyv080
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
resolves10.1002/sim.7492
Extending the MR‐Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy
resolves10.1038/s41588-018-0255-0
Distinguishing genetic correlation from causation across 52 diseases and complex traits
resolves10.7554/eLife.34408
The MR-Base platform supports systematic causal inference across the human phenome
resolves10.1042/bst0110639
Quantitative importance of different organs for cholesterol synthesis and low-density-lipoprotein degradation
resolves10.2337/db07-0056
Direct Effect of Cholesterol on Insulin Secretion
resolves10.1194/jlr.M800238-JLR200
Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
resolves10.1210/en.2002-220273
Low Density Lipoprotein Can Cause Death of Islet β-Cells by Its Cellular Uptake and Oxidative Modification
resolves10.1093/eurheartj/ehy357
PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: the role of the low-density lipoprotein receptor
resolves10.1007/s00125-010-1691-2
Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice
resolves10.1074/jbc.M300102200
Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins
resolves10.1194/jlr.R082271
Hypertriglyceridemia and cardiovascular risk: a cautionary note about metabolic confounding
resolves10.1001/jama.2015.1206
Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus
resolves10.1016/S2213-8587(16)30396-5
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
resolves10.1056/NEJMoa1604304
Variation in<i>PCSK9</i>and<i>HMGCR</i>and Risk of Cardiovascular Disease and Diabetes
resolves10.7555/JBR.34.20190124
LDL, LDL receptors, and PCSK9 as modulators of the risk for type 2 diabetes: a focus on white adipose tissue
resolves10.1161/CIRCULATIONAHA.116.026560
Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus
resolves10.1093/ije/dyg070
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
The 6 references without a DOI — listed, not checked
no DOI — not checkedHigh-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease
no DOI — not checked10.1016/S2666-7568(21)00086-6_bib22
no DOI — not checkedAssessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic
no DOI — not checkedTesting and correcting for weak and pleiotropic instruments in two-sample multivariable mendelian randomisation
no DOI — not checked10.1016/S2666-7568(21)00086-6_bib31
no DOI — not checkedFamilial combined hyperlipidemia: current knowledge, perspectives, and controversies
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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