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Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis
127/127 checkable references clean · checked 2026-07-24
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 127 checked references that resolve
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The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3
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Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)
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The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-nonene
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Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.
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Identification and Characterization of Multiple Osmotic Response Sequences in the Human Aldose Reductase Gene
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Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms
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Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.
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Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members
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Activation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiol Proximate Carcinogens by Human Aldo-keto Reductase (AKR1C) Enzymes and Their Functional Overexpression in Human Lung Carcinoma (A549) Cells
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The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen <i>trans</i>-Dihydrodiols to <i>o</i>-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation
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Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol
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Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta
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Dihydrodiol dehydrogenases regulate the generation of reactive oxygen species and the development of cisplatin resistance in human ovarian carcinoma cells
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Increased Expression of Dihydrodiol Dehydrogenase Induces Resistance to Cisplatin in Human Ovarian Carcinoma Cells
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Anthracycline resistance mediated by reductive metabolism in cancer cells: The role of aldo-keto reductase 1C3
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Inactivation of the anticancer drugs doxorubicin and oracin by aldo–keto reductase (AKR) 1C3
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Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer
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Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2 synthase activity of aldo-ketoreductase 1B1
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Identification of a Principal mRNA Species for Human 3 -Hydroxysteroid Dehydrogenase Isoform (AKR1C3) That Exhibits High Prostaglandin D2 11-Ketoreductase Activity
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cDNA cloning, expression and characterization of human prostaglandin F synthase<sup>1</sup>
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Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo–keto reductase superfamily
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Expression and Characterization of Recombinant Type 2 3α-Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3α/17β-HSD Activity and Cellular Distribution
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Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
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Human Type 3 3α-Hydroxysteroid Dehydrogenase (Aldo-Keto Reductase 1C2) and Androgen Metabolism in Prostate Cells
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Tibolone Is Metabolized by the 3α/3β-Hydroxysteroid Dehydrogenase Activities of the Four Human Isozymes of the Aldo-Keto Reductase 1C Subfamily: Inversion of Stereospecificity with a Δ5(10)-3-Ketosteroid
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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
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Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates
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Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles
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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
resolves10.1073/pnas.1305687110
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
resolves10.1128/MCB.01204-10
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
resolves10.1038/onc.2012.388
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
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The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
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Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.
resolves10.1016/j.freeradbiomed.2015.06.021
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
resolves10.1002/hep.24493
Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity
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Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A
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Identification of aldo-keto reductases as NRF2-target marker genes in human cells
resolves10.1016/j.cbi.2011.09.007
Human aldo–keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells
resolves10.1016/j.cbi.2014.10.019
Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2
resolves10.1093/carcin/bgp176
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
resolves10.1007/s10549-011-1536-9
Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
resolves10.1016/S0026-895X(25)13665-1
Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.
resolves10.1016/0005-2728(94)90144-9
cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase
resolves10.1073/pnas.0501475102
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype
resolves10.1093/carcin/bgg016
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter
resolves10.1073/pnas.90.21.10350
An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.
resolves10.1021/tx7004458
Protection Against Aflatoxin B<sub>1</sub>-Induced Cytotoxicity by Expression of the Cloned Aflatoxin B<sub>1</sub>-Aldehyde Reductases Rat AKR7A1 and Human AKR7A3
resolves10.1158/1078-0432.CCR-04-1238
Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non–Small Cell Lung Carcinomas
resolves10.1016/j.toxlet.2006.03.008
Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells
resolves10.1002/path.2039
Smoking and cancer‐related gene expression in bronchial epithelium and non‐small‐cell lung cancers
resolves10.1158/1940-6207.CAPR-08-0007
Effects of Tobacco Smoke on Gene Expression and Cellular Pathways in a Cellular Model of Oral Leukoplakia
resolves10.1152/physiolgenomics.00167.2009
Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium
resolves10.1158/1940-6207.CAPR-07-0017
Impact of Smoking Cessation on Global Gene Expression in the Bronchial Epithelium of Chronic Smokers
resolves10.1371/journal.pmed.0030420
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
resolves10.4161/epi.6.6.15773
Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
resolves10.1042/BJ20051988
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids
resolves10.1378/chest.09-2634
Smoking-Induced Upregulation of AKR1B10 Expression in the Airway Epithelium of Healthy Individuals
resolves10.1016/S0090-9556(24)02973-8
ENANTIOSELECTIVITY OF CARBONYL REDUCTION OF 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE BY TISSUE FRACTIONS FROM HUMAN AND RAT AND BY ENZYMES ISOLATED FROM HUMAN LIVER
resolves10.1016/0891-5849(91)90192-6
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
resolves10.1021/tx0600503
Translesion DNA Synthesis across the Heptanone−Etheno-2‘-Deoxycytidine Adduct in Cells
resolves10.1074/jbc.M109.022897
Aldo-keto Reductase Family 1 Member B10 Promotes Cell Survival by Regulating Lipid Synthesis and Eliminating Carbonyls
resolves10.1016/j.bbrc.2009.06.123
Aldo–keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels
resolves10.1016/j.neuint.2012.10.007
Aldo–keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells
resolves10.1097/CAD.0b013e3283448df0
Involvement of the aldo–keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms
resolves10.1593/neo.10526
Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression
resolves10.2174/156800908784293631
The Gene Expression Profiles of Medulloblastoma Cell Lines Resistant to Preactivated Cyclophosphamide
resolves10.1016/S0026-895X(25)10169-7
Aldose reductase-catalyzed reduction of acrolein: implications in cyclophosphamide toxicity.
resolves10.3389/fphar.2012.00005
Aldo–Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers
resolves10.1124/dmd.108.020388
Aldo-Keto Reductase 1C2 Fails to Metabolize Doxorubicin and Daunorubicin in Vitro
resolves10.1097/FPC.0b013e32832c484b
Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance
resolves10.1016/j.tox.2007.05.021
Aldo-keto reductases (AKR) from the AKR1C subfamily catalyze the carbonyl reduction of the novel anticancer drug oracin in man
resolves10.1158/0008-5472.CAN-14-3080
Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer
resolves10.1093/toxsci/kfp003
Transgenic Expression of Aflatoxin Aldehyde Reductase (AKR7A1) Modulates Aflatoxin B1 Metabolism but not Hepatic Carcinogenesis in the Rat
resolves10.1021/tx8002005
Oxidation of PAH <i>trans</i>-Dihydrodiols by Human Aldo-Keto Reductase AKR1B10
resolves10.1021/tx950055s
Generation of Reactive Oxygen Species during the Enzymatic Oxidation of Polycyclic Aromatic Hydrocarbon <i>trans</i>-Dihydrodiols Catalyzed by Dihydrodiol Dehydrogenase
resolves10.1016/S0021-9258(19)84546-5
Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons.
resolves10.1016/S0021-9258(19)77949-6
Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism.
resolves10.1073/pnas.0802776105
Evidence for the aldo-keto reductase pathway of polycyclic aromatic
<i>trans</i>
-dihydrodiol activation in human lung A549 cells
resolves10.1074/jbc.M112.386052
Detoxication of Benzo[a]pyrene-7,8-dione by Sulfotransferases (SULTs) in Human Lung Cells
resolves10.1021/tx400268q
Interception of Benzo[<i>a</i>]pyrene-7,8-dione by UDP Glucuronosyltransferases (UGTs) in Human Lung Cells
resolves10.1074/jbc.M111.240739
Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols
resolves10.1021/tx200294c
Specificity of Human Aldo-Keto Reductases, NAD(P)H:Quinone Oxidoreductase, and Carbonyl Reductases to Redox-Cycle Polycyclic Aromatic Hydrocarbon Diones and 4-Hydroxyequilenin-<i>o-</i>quinone
resolves10.1124/jpet.107.127068
CYP2A13: Variable Expression and Role in Human Lung Microsomal Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
resolves10.1093/carcin/12.11.2069
<i>In vivo</i> and <i>in vitro</i> persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
resolves10.1021/tx700189c
Development of Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Methods for Analysis of DNA Adducts of Formaldehyde and Their Application to Rats Treated with <i>N</i>-Nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
resolves10.1021/tx060207r
Formation and Accumulation of Pyridyloxobutyl DNA Adducts in F344 Rats Chronically Treated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
resolves10.1093/carcin/bgh120
Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
resolves10.1016/B978-0-12-398312-1.00004-4
Structural, Functional, and Mutagenesis Studies of UDP-Glycosyltransferases
resolves10.1016/S0006-291X(02)02789-4
DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats
resolves10.1158/0008-5472.CAN-04-3544
Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols
resolves10.1093/carcin/10.2.369
Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice
resolves10.1021/tx0500474
Synthesis, Characterization, and <sup>32</sup>P-Postlabeling Analysis of DNA Adducts Derived from the Environmental Contaminant 3-Nitrobenzanthrone
resolves10.1016/j.freeradbiomed.2005.11.015
Carcinogenic 3-nitrobenzanthrone induces oxidative damage to isolated and cellular DNA
resolves10.1016/j.tox.2008.01.018
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity
resolves10.1158/1940-6207.CAPR-08-0047
Genomics of Smoking Exposure and Cessation: Lessons for Cancer Prevention and Treatment
resolves10.1073/pnas.0705659105
Structural basis for the high
<i>all-trans</i>
-retinaldehyde reductase activity of the tumor marker AKR1B10
resolves10.1074/jbc.273.4.1855
Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ
resolves10.1371/journal.pone.0008147
Combined Bezafibrate and Medroxyprogesterone Acetate: Potential Novel Therapy for Acute Myeloid Leukaemia
resolves10.1016/j.mce.2005.10.009
AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer
resolves10.18632/oncotarget.7004
Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway
resolves10.1021/acs.jmedchem.6b00160
Discovery of (<i>R</i>)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor
resolves10.1021/jm201547v
Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on<i>N</i>-Phenyl-Aminobenzoates and Their Structure–Activity Relationships
resolves10.1016/j.bmcl.2012.03.085
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer
resolves10.1007/s10637-014-0130-5
In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3)
resolves10.1021/jm3017656
Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer
resolves10.1007/s10637-014-0101-x
Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study
resolves10.1158/1078-0432.CCR-13-1151
Steroidogenic Enzyme AKR1C3 Is a Novel Androgen Receptor-Selective Coactivator that Promotes Prostate Cancer Growth
resolves10.3389/fonc.2014.00159
The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer
resolves10.1093/carcin/21.12.2287
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
resolves10.1073/pnas.051618798
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in
<i>nrf2</i>
transcription factor-deficient mice
resolves10.1093/carcin/7.8.1379
Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithioI-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard
resolves10.1016/j.freeradbiomed.2006.06.015
Oltipraz chemoprevention trial in Qidong, People's Republic of China: Unaltered oxidative biomarkers
resolves10.1002/jcb.240590814
Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver
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no DOI — not checkedCasarett and Doull’s Toxicology
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