Reference health
Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution
49/49 checkable references clean · checked 2026-07-26
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
4 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 49 checked references that resolve
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Tracking cancer drugs in living cells by thermal profiling of the proteome
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Target identification using drug affinity responsive target stability (DARTS)
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A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication
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Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding
resolves10.1073/pnas.0605224103
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
resolves10.1038/nchembio.2185
Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat
resolves10.1021/acsmedchemlett.8b00081
Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift
resolves10.1016/j.cell.2018.03.053
Pervasive Protein Thermal Stability Variation during the Cell Cycle
resolves10.1038/nmeth.3590
Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling
resolves10.1126/science.1233606
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
resolves10.1016/j.ab.2004.04.031
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
resolves10.1038/nprot.2007.321
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
resolves10.2174/0929867054546564
Differential Scanning Calorimetry in Life Science: Thermodynamics, Stability, Molecular Recognition and Application in Drug Design
resolves10.1021/bi00481a024
Study of strong to ultratight protein interactions using differential scanning calorimetry
resolves10.1021/ac100465a
Mass Spectrometry-Based Thermal Shift Assay for Protein−Ligand Binding Analysis
resolves10.1016/j.yexmp.2008.12.001
Differential scanning calorimetry of blood plasma for clinical diagnosis and monitoring
resolves10.1371/journal.pone.0195050
A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells
resolves10.15252/embj.201798359
Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib
resolves10.1039/C6SC03238A
Label-free target identification using in-gel fluorescence difference
<i>via</i>
thermal stability shift
resolves10.1016/j.jprot.2018.05.018
Thermal proteome profiling allows quantitative assessment of interactions between tetrachloroethene reductive dehalogenase and trichloroethene
resolves10.1186/s12953-017-0122-4
Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes
resolves10.1074/mcp.RA118.001124
Proteome-wide Analysis of Protein Thermal Stability in the Model Higher Plant Arabidopsis thaliana
resolves10.1002/pmic.201800118
Dynamic Proteomics Reveals High Plasticity of Cellular Proteome: Growth‐Related and Drug‐Induced Changes in Cancer Cells are Comparable
resolves10.3109/10409237809177141
Thermodynamic Characterization of Conformational States of Biological Macromolecules using Differential Scanning Calorimetry
resolves10.1021/jacs.7b02774
Melting Proteins: Evidence for Multiple Stable Structures upon Thermal Denaturation of Native Ubiquitin from Ion Mobility Spectrometry-Mass Spectrometry Measurements
resolves10.1038/nprot.2015.101
Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
resolves10.1038/nbt.1511
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
resolves10.1093/nar/gky1106
The PRIDE database and related tools and resources in 2019: improving support for quantification data
resolves10.1038/srep44015
Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis
resolves10.1073/pnas.172501499
Interaction of dihydrofolate reductase with methotrexate: Ensemble and single-molecule kinetics
resolves10.1038/ncomms11040
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
resolves10.1038/nprot.2014.138
The cellular thermal shift assay for evaluating drug target interactions in cells
resolves10.1038/srep11176
Functional Identification of Target by Expression Proteomics (FITExP) reveals protein targets and highlights mechanisms of action of small molecule drugs
resolves10.1261/rna.966208
Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast
resolves10.1110/ps.051493605
Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA‐sequestering peripheral protein domain
resolves10.1080/15476286.2016.1276150
Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression?
resolves10.1093/nar/19.22.6139
Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil
resolves10.1093/nar/gkl1084
Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo
resolves10.1074/mcp.RA118.000610
Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions
resolves10.1021/acschembio.5b01063
Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors
resolves10.1126/science.aai7825
Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability
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