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Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors
33/33 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 33 checked references that resolve
resolves10.1073/pnas.0700373104
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
resolves10.1517/14728222.12.2.223
Class IA phosphatidylinositol 3-kinase: from their biologic implication in human cancers to drug discovery
resolves10.1124/pr.110.004051
Inhibition of PI3K Signaling Spurs New Therapeutic Opportunities in Inflammatory/Autoimmune Diseases and Hematological Malignancies
resolves10.1038/nri2036
PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?
resolves10.1126/science.287.5455.1049
Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation
resolves10.1126/science.287.5455.1046
Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
resolves10.1016/j.cell.2004.07.017
PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects
resolves10.1084/jem.20020805
A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
resolves10.1128/MCB.22.24.8580-8591.2002
Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex
resolves10.1126/science.1073560
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
resolves10.4049/jimmunol.170.5.2647
Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement
resolves10.1183/09031936.00106609
Phosphoinositide 3-kinase δ inhibitor suppresses interleukin-17 expression in a murine asthma model
resolves10.3109/08916934.2012.732130
Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice
resolves10.1021/jm501624r
Discovery and in Vivo Evaluation of (<i>S</i>)-<i>N</i>-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9<i>H</i>-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
resolves10.1021/acs.jmedchem.5b01651
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors
resolves10.1158/1535-7163.MCT-08-0017
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent
<i>in vivo</i>
antitumor activity
resolves10.1038/nm1284
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
resolves10.1016/S0014-2999(01)01362-0
[3H]Dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen
resolves10.1021/jm049377w
High-Throughput Lipophilicity Measurement with Immobilized Artificial Membranes
resolves10.1021/jm8008663
Metabolic Soft Spot Identification and Compound Optimization in Early Discovery Phases Using MetaSite and LC-MS/MS Validation
resolves10.1038/nchembio.293
The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
resolves10.1021/acs.jctc.5b00255
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
resolves10.4049/jimmunol.179.11.7891
Tissue- and Stimulus-Dependent Role of Phosphatidylinositol 3-Kinase Isoforms for Neutrophil Recruitment Induced by Chemoattractants In Vivo
resolves10.1182/blood-2009-07-232330
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
The 1 reference without a DOI — listed, not checked
no DOI — not checkedAMBER 2015
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