Every reference with a DOI in the deposited reference list resolved to a known
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The 183 checked references that resolve
resolves10.1126/science.283.5400.401Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB
<sub>1</sub>
Receptor Knockout Mice
resolves10.1073/pnas.96.10.5780Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
resolves10.1126/science.1470919Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
resolves10.1016/0006-2952(95)00109-DIdentification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
resolves10.1006/bbrc.1995.24372-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
resolves10.1016/j.chembiol.2007.05.014Endocannabinoids and Related Compounds: Walking Back and Forth between Plant Natural Products and Animal Physiology
resolves10.1098/rspb.1998.0543A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain.
resolves10.1523/JNEUROSCI.19-11-04544.1999Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
resolves10.1016/S0026-895X(24)26516-0Endocannabinoid 2-Arachidonyl Glycerol Is a Full Agonist through Human Type 2 Cannabinoid Receptor: Antagonism by Anandamide
resolves10.1124/mol.55.1.8Δ<sup>9</sup>-Tetrahydrocannabinol Acts as a Partial Agonist to Modulate Glutamatergic Synaptic Transmission between Rat Hippocampal Neurons in Culture
resolves10.1523/JNEUROSCI.4403-06.2007Specific Alterations of Extracellular Endocannabinoid Levels in the Nucleus Accumbens by Ethanol, Heroin, and Cocaine Self-Administration
resolves10.1111/j.1460-9568.2007.05900.xCB1 receptor‐mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus
resolves10.1021/jm058183tThe Endocannabinoid System: Drug Targets, Lead Compounds, and Potential Therapeutic Applications
resolves10.1016/j.plipres.2006.03.003Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
resolves10.1074/jbc.270.40.23823Partial Purification and Characterization of the Porcine Brain Enzyme Hydrolyzing and Synthesizing Anandamide
resolves10.1016/0005-2760(95)00087-SCharacterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain
resolves10.1016/0014-5793(95)01311-3Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’
resolves10.1038/384083a0Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
resolves10.1111/j.1460-9568.2004.03428.xSegregation of two endocannabinoid‐hydrolyzing enzymes into pre‐ and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala
resolves10.1021/bi981733nComparative Characterization of a Wild Type and Transmembrane Domain-Deleted Fatty Acid Amide Hydrolase: Identification of the Transmembrane Domain as a Site for Oligomerization
resolves10.1126/science.1076535Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling
resolves10.1093/emboj/21.11.2509Structure of malonamidase E2 reveals a novel Ser‐cisSer‐Lys catalytic triad in a new serine hydrolase fold that is prevalent in nature
resolves10.1021/bi002578rCharacterization and Manipulation of the Acyl Chain Selectivity of Fatty Acid Amide Hydrolase
resolves10.1021/bi990637zChemical and Mutagenic Investigations of Fatty Acid Amide Hydrolase: Evidence for a Family of Serine Hydrolases with Distinct Catalytic Properties
resolves10.1074/jbc.M001607200Clarifying the Catalytic Roles of Conserved Residues in the Amidase Signature Family
resolves10.1074/jbc.M303922200Evidence for Distinct Roles in Catalysis for Residues of the Serine-Serine-Lysine Catalytic Triad of Fatty Acid Amide Hydrolase
resolves10.1021/bi991876pFatty Acid Amide Hydrolase Competitively Degrades Bioactive Amides and Esters through a Nonconventional Catalytic Mechanism
resolves10.1073/pnas.161191698Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
resolves10.1016/j.ejphar.2006.11.002Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors
resolves10.1159/000087925Cocaine- and Amphetamine-Related Transcript Is Involved in the Orexigenic Effect of Endogenous Anandamide
resolves10.1016/j.pain.2004.01.022Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia
resolves10.1073/pnas.0401292101Functional disassociation of the central and peripheral fatty acid amide signaling systems
resolves10.1016/j.neuropharm.2007.07.005Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
resolves10.1093/sleep/27.5.857Characterization of the Sleep-wake Patterns in Mice Lacking Fatty Acid Amide Hydrolase
resolves10.1038/sj.npp.1301224Inhibition of Fatty-Acid Amide Hydrolase Accelerates Acquisition and Extinction Rates in a Spatial Memory Task
resolves10.1016/S0960-894X(98)00734-3Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: A probe of structural and conformational features contributing to inhibition
resolves10.1074/jbc.270.1.445Inhibition of Macrophage Ca2+-independent Phospholipase A2 by Bromoenol Lactone and Trifluoromethyl Ketones
resolves10.1124/jpet.103.055392Inhibition of Platelet-Activating Factor (PAF) Acetylhydrolase by Methyl Arachidonyl Fluorophosphonate Potentiates PAF Synthesis in Thrombin-Stimulated Human Coronary Artery Endothelial Cells
resolves10.1073/pnas.97.10.5044Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
resolves10.1124/jpet.104.069401Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity
resolves10.1038/sj.bjp.0706699Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms
resolves10.1038/nm803Modulation of anxiety through blockade of anandamide hydrolysis
resolves10.1016/j.chembiol.2005.08.011Mechanism of Carbamate Inactivation of FAAH: Implications for the Design of Covalent Inhibitors and In Vivo Functional Probes for Enzymes
resolves10.1038/sj.bjp.0706348Inhibitors of fatty acid amide hydrolase reduce carrageenan‐induced hind paw inflammation in pentobarbital‐treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
resolves10.1038/sj.bjp.0706510Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models
resolves10.1124/jpet.107.119941The Fatty Acid Amide Hydrolase Inhibitor URB597 (Cyclohexylcarbamic Acid 3′-Carbamoylbiphenyl-3-yl Ester) Reduces Neuropathic Pain after Oral Administration in Mice
resolves10.1073/pnas.0509591102Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
resolves10.1124/jpet.106.101287Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid Signaling
resolves10.1016/j.biopsych.2006.12.001Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress
resolves10.1152/ajpheart.00373.2007Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase
resolves10.1007/s00213-007-0970-1The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat
resolves10.1124/jpet.104.078980Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation
resolves10.1021/bi701378gNovel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity
resolves10.1016/j.bcp.2005.01.012A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening
resolves10.1038/nbt826Discovering potent and selective reversible inhibitors of enzymes in complex proteomes
resolves10.1016/j.bmcl.2004.12.085Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity
resolves10.1021/jm049614vDiscovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics
resolves10.1021/bi0480335Assignment of Endogenous Substrates to Enzymes by Global Metabolite Profiling
resolves10.1021/bi0608008A FAAH-Regulated Class of <i>N-</i>Acyl Taurines That Activates TRP Ion Channels
resolves10.1021/bi0608010Structure-Based Design of a FAAH Variant That Discriminates between the <i>N</i>-Acyl Ethanolamine and Taurine Families of Signaling Lipids
resolves10.1038/372686a0Formation and inactivation of endogenous cannabinoid anandamide in central neurons
resolves10.1111/j.1472-8206.2006.00442.xThe cannabinoid system and its pharmacological manipulation – a review, with emphasis upon the uptake and hydrolysis of anandamide
resolves10.1074/jbc.M003161200The Cellular Uptake of Anandamide Is Coupled to Its Breakdown by Fatty-acid Amide Hydrolase
resolves10.1124/mol.59.6.1369Role of Fatty Acid Amide Hydrolase in the Transport of the Endogenous Cannabinoid Anandamide
resolves10.1073/pnas.0507470102Identification of a high-affinity binding site involved in the transport of endocannabinoids
resolves10.1046/j.1471-4159.2000.0742597.xStructure—Activity Relationships Among <i>N</i>‐Arachidonylethanolamine (Anandamide) Head Group Analogues for the Anandamide Transporter
resolves10.1038/sj.bjp.0706253Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate
resolves10.1021/ja062999hThe Putative Endocannabinoid Transport Blocker LY2183240 Is a Potent Inhibitor of FAAH and Several Other Brain Serine Hydrolases
resolves10.1007/s10571-006-9072-6Pharmacological Characterization of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Inhibitors
resolves10.1021/bi049395fComparison of Anandamide Transport in FAAH Wild-Type and Knockout Neurons: Evidence for Contributions by both FAAH and the CB1 Receptor to Anandamide Uptake
resolves10.1074/jbc.M509721200Anandamide Uptake Is Consistent with Rate-limited Diffusion and Is Regulated by the Degree of Its Hydrolysis by Fatty Acid Amide Hydrolase
resolves10.1073/pnas.0400997101Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
resolves10.1074/jbc.M407250200A Role for Caveolae/Lipid Rafts in the Uptake and Recycling of the Endogenous Cannabinoid Anandamide
resolves10.1073/pnas.082235799A missense mutation in human fatty acid amide hydrolase associated with problem drug use
resolves10.1093/hmg/ddh216Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use
resolves10.1002/ajmg.b.30491The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: Studies of drug use and dependence in caucasians
resolves10.1016/j.neulet.2004.11.050A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
resolves10.1097/YPG.0b013e32809913d8Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
resolves10.1038/sj.ijo.0802954Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)
resolves10.1007/s00109-006-0139-0The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites
resolves10.1055/s-2007-977694Genetic Variation in Two Proteins of the Endocannabinoid System and their Influence on Body Mass Index and Metabolism under Low Fat Diet
resolves10.1074/jbc.M606646200A Second Fatty Acid Amide Hydrolase with Variable Distribution among Placental Mammals
resolves10.1074/jbc.M106261200Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance
resolves10.1074/jbc.M413473200Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase
resolves10.1042/bj20031695N-Cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase
resolves10.1016/j.bbalip.2005.08.010Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages
resolves10.1006/geno.1999.5953Molecular Cloning and Characterization of a Human cDNA and Gene Encoding a Novel Acid Ceramidase-like Protein
resolves10.1016/j.bbalip.2007.03.005Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies
resolves10.1038/sj.npp.1301274Role of Endocannabinoids in Alcohol Consumption and Intoxication: Studies of Mice Lacking Fatty Acid Amide Hydrolase
resolves10.1093/molehr/8.2.188Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer
resolves10.1172/JCI28621Fatty acid amide hydrolase deficiency limits early pregnancy events
resolves10.1016/S0021-9258(17)44667-9Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type.
resolves10.1074/jbc.M306642200Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners
resolves10.1038/35071088Leptin-regulated endocannabinoids are involved in maintaining food intake
resolves10.1021/bi060163lInactivation of <i>N</i>-Acyl Phosphatidylethanolamine Phospholipase D Reveals Multiple Mechanisms for the Biosynthesis of Endocannabinoids
resolves10.1074/jbc.M512359200Functional Analysis of the Purified Anandamide-generating Phospholipase D as a Member of the Metallo-β-lactamase Family
resolves10.1042/bj20040031Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D
resolves10.1074/jbc.M604660200Endocannabinoid Biosynthesis Proceeding through Glycerophospho-N-acyl Ethanolamine and a Role for α/β-Hydrolase 4 in This Pathway
resolves10.1074/jbc.M606369200Discovery and Characterization of a Ca2+-independent Phosphatidylethanolamine N-Acyltransferase Generating the Anandamide Precursor and Its Congeners
resolves10.1124/jpet.302.1.73Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo
resolves10.1074/jbc.272.43.27218cDNA Cloning, Tissue Distribution, and Identification of the Catalytic Triad of Monoglyceride Lipase
resolves10.1523/JNEUROSCI.2419-04.2004ATP Induces a Rapid and Pronounced Increase in 2-Arachidonoylglycerol Production by Astrocytes, a Response Limited by Monoacylglycerol Lipase
resolves10.1124/mol.104.002071RNA Interference Suggests a Primary Role for Monoacylglycerol Lipase in the Degradation of the Endocannabinoid 2-Arachidonoylglycerol
resolves10.1016/j.chembiol.2005.04.013Characterization of the Sulfhydryl-Sensitive Site in the Enzyme Responsible for Hydrolysis of 2- Arachidonoyl-Glycerol in Rat Cerebellar Membranes
resolves10.1038/nn1521Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
resolves10.1038/nn0107-134aErratum: Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
resolves10.1038/sj.bjp.0706971Lack of selectivity of URB602 for 2‐oleoylglycerol compared to anandamide hydrolysis <i>in vitro</i>
resolves10.1523/JNEUROSCI.4159-06.2007Presynaptic Monoacylglycerol Lipase Activity Determines Basal Endocannabinoid Tone and Terminates Retrograde Endocannabinoid Signaling in the Hippocampus
resolves10.1002/cbic.200700139Disulfiram is an Inhibitor of Human Purified Monoacylglycerol Lipase, the Enzyme Regulating 2‐Arachidonoylglycerol Signaling
resolves10.1038/nmeth778A streamlined platform for high-content functional proteomics of primary human specimens
resolves10.1016/0014-5793(77)80099-9Hormone‐sensitive lipase of rat adipose tissue: Identification and some properties of the enzyme protein
resolves10.1074/jbc.M007088200Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2
resolves10.1038/nn1262Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus
resolves10.1083/jcb.200305129Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
resolves10.1523/JNEUROSCI.0054-06.2006Localization of Diacylglycerol Lipase-α around Postsynaptic Spine Suggests Close Proximity between Production Site of an Endocannabinoid, 2-Arachidonoyl-glycerol, and Presynaptic Cannabinoid CB1 Receptor
resolves10.1523/JNEUROSCI.0448-07.2007Subcellular Arrangement of Molecules for 2-Arachidonoyl-Glycerol-Mediated Retrograde Signaling and Its Physiological Contribution to Synaptic Modulation in the Striatum
resolves10.1113/jphysiol.2006.119362Depolarization‐induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2‐arachidonoylglycerol
resolves10.1124/mol.107.037796A Key Role for Diacylglycerol Lipase-α in Metabotropic Glutamate Receptor-Dependent Endocannabinoid Mobilization
resolves10.1124/mol.105.013961Stimulation of Endocannabinoid Formation in Brain Slice Cultures through Activation of Group I Metabotropic Glutamate Receptors
resolves10.1016/j.neuron.2005.01.004Phospholipase Cβ Serves as a Coincidence Detector through Its Ca2+ Dependency for Triggering Retrograde Endocannabinoid Signal
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