Reference health
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP
20/20 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
7 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 20 checked references that resolve
resolves10.1080/10641269891314294
Paralytic Shellfish Toxins in Bivalve Molluscs: Occurrence, Transfer Kinetics, and Biotransformation
resolves10.1016/0041-0101(72)90012-8
Resistance to tetrodotoxin and saxitoxin in nerves of bivalve molluscs
resolves10.1085/jgp.51.2.177
Interaction of DDT with the Components of Lobster Nerve Membrane Conductance
resolves10.1152/physrev.1996.76.3.887
Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms
resolves10.1016/0014-5793(91)81159-6
Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II
resolves10.1126/science.256.5060.1202
A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties
resolves10.1016/S0014-5793(97)00479-1
A single serine residue confers tetrodotoxin insensitivity on the rat sensory‐neuron‐specific sodium channel SNS
resolves10.1038/ng1089
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
resolves10.1073/pnas.87.1.323
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.
resolves10.1016/S0006-3495(94)80746-5
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel
resolves10.3354/meps069047
Relative insensitivity of butter clam neurons to saxitoxin; a pre-adaptation for sequestering paralytic shellfish poisoning toxins as a chemical defense
resolves10.1002/(SICI)1520-6327(1998)37:1<73::AID-ARCH9>3.0.CO;2-W
Effects of exposure to cypermethrin on saxitoxin binding in susceptible and pyrethroid-resistant houseflies
resolves10.1006/bbrc.1999.1076
Identification of a Point Mutation in the para-Type Sodium Channel Gene from a Pyrethroid-Resistant Cattle Tick
resolves10.1006/bbrc.1999.1974
Binding Properties of 3H-PbTx-3 and 3H-Saxitoxin to Brain Membranes and to Skeletal Muscle Membranes of Puffer Fish Fugu pardalis and the Primary Structure of a Voltage-Gated Na+ Channel α-Subunit (fMNa1) from Skeletal Muscle of F. pardalis
resolves10.1126/science.1074310
Mechanisms of Adaptation in a Predator-Prey Arms Race: TTX-Resistant Sodium Channels
resolves10.3354/meps074033
Influence of dinoflagellate cell toxicity on uptake and loss of paralytic shellfish toxins in the northern quahog Mercenaria mercenaria
resolves10.1073/pnas.95.23.13947
Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel
The 7 references without a DOI — listed, not checked
no DOI — not checkedTwarog, B. M. in Proc. 2nd Int. Coral Reef Symp. Vol. 1 (eds Cameron, A. M. et al.) 505–512 (Barrier Reef Committee, Brisbane, 1974)
no DOI — not checkedHallegraeff, G. M. in Manual on Harmful Marine Microalgae (eds Hallegraeff, G. M., Anderson, D. M. & Cembella, A. D.) 25–49 (UNESCO, Paris, 2003)
no DOI — not checkedMartin, J. L. & Richard, D. in Harmful and Toxic Algal Blooms (eds Yasumoto, T., Oshima, Y. & Fukuyo, Y.) 3–6 (International Oceanographic Commission of UNESCO, Paris, 1996)
no DOI — not checkedBricelj, V. M., Cembella, A. D., Laby, D., Shumway, S. E. & Cucci, T. L. in Harmful and Toxic Algal Blooms (eds Yasumoto, T., Oshima, Y. & Fukuyo, Y.) 405–408 (International Oceanographic Commission of UNESCO, Paris, 1996)
no DOI — not checkedMacQuarrie, S. P. Inter- and Intra-population Variability in Behavioral and Physiological Responses of the Softshell Clam, Mya arenaria, to the PSP Toxin-producing Dinoflagellate, Alexandrium tamarense. Thesis, Dalhousie Univ. (2002)
no DOI — not checkedKontis, K. J. & Goldin, A. L. Site-directed mutagenesis of the putative pore region of the rat IIA sodium channel. Mol. Pharmacol. 43, 635–644 (1993)
no DOI — not checkedOshima, Y. in Manual on Harmful Marine Microalgae (eds Hallegraeff, G. M., Anderson, D. M. & Cembella, A. D.) 81–94 (International Oceanographic Commission Manuals and Guides 33, UNESCO, Paris, 1995)
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work were clean at the dated check: each resolved to a known work in a public registry, and none
carried a retraction notice at that time. It says nothing about the quality, findings,
or importance of the work itself, and nothing about references deposited without a DOI.
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