Reference health

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

https://doi.org/10.1038/nature08460
CiteStamped reference-health badge
31/31 checkable references clean · checked 2026-07-24

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

The 31 checked references that resolve
resolves10.1126/science.278.5340.1064
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
resolves10.1038/nrc1691
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
resolves10.1016/j.cell.2006.01.040
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
resolves10.1038/nbt1186
Statistical practice in high-throughput screening data analysis
resolves10.1093/bioinformatics/btl196
Comparative gene marker selection suite
resolves10.1073/pnas.0810485105
Highly parallel identification of essential genes in cancer cells
resolves10.1073/pnas.0506580102
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
resolves10.1038/sj.onc.1205550
Immortalization and transformation of primary human airway epithelial cells by gene transfer
resolves10.1158/0008-5472.CAN-04-4420
Inhibition of Mammalian Target of Rapamycin Reverses Alveolar Epithelial Neoplasia Induced by Oncogenic <i>K-ras</i>
resolves10.1016/j.cell.2006.08.034
RalB GTPase-Mediated Activation of the IκB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival
resolves10.1126/stke.3572006re13
Regulation and Function of IKK and IKK-Related Kinases
resolves10.1038/nature04296
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
resolves10.1038/sj.onc.1206198
Divergent gene regulation and growth effects by NF-κB in epithelial and mesenchymal cells of human skin
resolves10.1016/j.cell.2007.03.052
Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene
resolves10.1038/nature07423
Somatic mutations affect key pathways in lung adenocarcinoma
resolves10.1200/JCO.2005.03.8224
Expression Profile–Defined Classification of Lung Adenocarcinoma Shows Close Relationship With Underlying Major Genetic Changes and Clinicopathologic Behaviors
resolves10.1038/sj.gene.6364449
IRF-3-dependent and augmented target genes during viral infection
resolves10.1016/j.ccr.2009.03.022
A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival
resolves10.1126/science.278.5344.1812
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
resolves10.1126/science.7878466
Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation
resolves10.4049/jimmunol.177.4.2527
Nuclear Accumulation of cRel following C-Terminal phosphorylation by TBK1/IKKε
resolves10.1101/gad.7.4.705
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
resolves10.4049/jimmunol.167.9.4948
c-Rel Is Required for the Protection of B Cells from Antigen Receptor-Mediated, But Not Fas-Mediated, Apoptosis
resolves10.1016/j.cell.2009.03.017
Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
resolves10.1016/j.cell.2009.05.006
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
resolves10.1038/nature04687
A loss-of-function RNA interference screen for molecular targets in cancer
resolves10.1073/pnas.0505114102
A TRAIL receptor-dependent synthetic lethal relationship between <i>MYC</i> activation and <i>GSK3β/FBW7</i> loss of function
resolves10.1126/science.1149185
Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening
resolves10.1111/1467-9868.00337
Powerful Goodness-of-fit Tests Based on the Likelihood Ratio
resolves10.1172/JCI37127
Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions
resolves10.1073/pnas.191502998
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

checked 2026-07-24 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record

Embed this badge

Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.

<a href="https://citestamp.com/citestamped/10.1038/nature08460"><img src="https://citestamp.com/citestamped/10.1038/nature08460/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>
[![CiteStamped reference-health badge](https://citestamp.com/citestamped/10.1038/nature08460/badge.svg)](https://citestamp.com/citestamped/10.1038/nature08460)