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Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme

https://doi.org/10.1038/nature10083
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33/33 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

4 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 33 checked references that resolve
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Uncovering cryptic genetic variation
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resolves10.1016/j.tree.2007.09.014
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resolves10.1038/24550
Hsp90 as a capacitor for morphological evolution
resolves10.1038/35035005
A yeast prion provides a mechanism for genetic variation and phenotypic diversity
resolves10.1534/genetics.105.051649
Cryptic Genetic Variation Is Enriched for Potential Adaptations
resolves10.1017/S0094837300004310
Exaptation—a Missing Term in the Science of Form
resolves10.1038/ng1482
The 'evolvability' of promiscuous protein functions
resolves10.1073/pnas.0510098103
Protein stability promotes evolvability
resolves10.1016/S0167-4781(99)00200-6
Characterization of the Azoarcus ribozyme: tight binding to guanosine and substrate by an unusually small group I ribozyme
resolves10.1126/science.1114994
Structural Evidence for a Two-Metal-Ion Mechanism of Group I Intron Splicing
resolves10.1073/pnas.0337743100
Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme
resolves10.1006/jmbi.1998.1901
Folding intermediates of a self-splicing RNA: mispairing of the catalytic core
resolves10.1126/science.1496376
Directed Evolution of an RNA Enzyme
resolves10.1038/361182a0
Evolution in vitro of an RNA enzyme with altered metal dependence
resolves10.1093/nar/24.11.2095
Thermodynamic effects of formamide on DNA stability
resolves10.1016/S1074-5521(99)80033-7
Catalytic promiscuity and the evolution of new enzymatic activities
resolves10.1261/rna.2110905
New ligase-derived RNA polymerase ribozymes
resolves10.1261/rna.1759009
Formation of an active site in <i>trans</i> by interaction of two complete Varkud Satellite ribozymes
resolves10.1073/pnas.211214298
Multidimensional epistasis and the disadvantage of sex
resolves10.1186/1471-2148-3-3
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
resolves10.1126/science.1123539
Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
resolves10.1534/genetics.104.029173
The Population Genetic Theory of Hidden Variation and Genetic Robustness
resolves10.1093/nar/gki380
Assembly PCR oligo maker: a tool for designing oligodeoxynucleotides for constructing long DNA molecules for RNA production
resolves10.1111/j.2517-6161.1995.tb02031.x
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
resolves10.1101/gr.2.1.28
Randomization of genes by PCR mutagenesis.
resolves10.1101/gr.1.1.17
DNA polymerase fidelity and the polymerase chain reaction.
resolves10.1016/0167-7799(94)90138-4
Inventing and improving ribozyme function: Rational design versus iterative selection methods
resolves10.1016/0022-2836(70)90057-4
A general method applicable to the search for similarities in the amino acid sequence of two proteins
resolves10.2144/000112124
Detection of High Levels of Recombination Generated During PCR Amplification of RNA Templates
resolves10.1093/bioinformatics/btl158
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
resolves10.1080/10635150390235520
A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood
The 4 references without a DOI — listed, not checked
no DOI — not checkedWagner, A. Robustness and Evolvability in Living Systems. (Princeton University Press, 2005)
no DOI — not checkedTanner, M. & Cech, T. Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus . RNA 2, 74–83 (1996)
no DOI — not checkedHartl, D. L. & Clark, A. G. Principles of Population Genetics. (Sinauer Associates, 1997)
no DOI — not checkedHanczyc, M. M. & Dorit, R. L. Experimental evolution of complexity: in vitro emergence of intermolecular ribozyme interactions. RNA 4, 268–275 (1998)
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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