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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
51/51 checkable references clean · checked 2026-08-28
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 51 checked references that resolve
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The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
resolves10.1172/JCI64098
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
resolves10.1016/j.devcel.2014.11.012
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
resolves10.1038/nature10599
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
resolves10.1126/science.aaf4445
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
resolves10.1038/nm.4000
Cellular senescence in aging and age-related disease: from mechanisms to therapy
resolves10.1016/j.cell.2008.03.039
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
resolves10.1101/gad.17276711
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
resolves10.1038/emboj.2011.69
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
resolves10.1126/science.aaa5612
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
resolves10.1126/science.1232458
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
resolves10.1016/j.celrep.2013.05.009
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
resolves10.1038/nature12306
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
resolves10.1016/j.molcel.2013.05.022
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
resolves10.1016/j.cell.2013.04.046
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
resolves10.1073/pnas.1516465112
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
resolves10.4049/jimmunol.1500969
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome
resolves10.4049/jimmunol.1400737
TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner
resolves10.1016/j.immuni.2014.10.019
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
resolves10.1038/ncb1024
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
resolves10.1371/journal.pbio.0060301
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
resolves10.1038/ncb2784
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
resolves10.1091/mbc.e05-09-0858
DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation
resolves10.1016/j.celrep.2015.03.069
DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function
resolves10.1016/j.celrep.2016.03.006
Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression
resolves10.1111/j.1474-9726.2010.00567.x
Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
resolves10.1038/nature05529
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
resolves10.1126/science.aaf6659
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
resolves10.1038/nm.4324
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
resolves10.4049/jimmunol.1100088
MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP
resolves10.1126/science.8009221
Functional Role of Type I and Type II Interferons in Antiviral Defense
resolves10.4161/cc.28401
Partial inhibition of Cdk1 in G<sub>2</sub>phase overrides the SAC and decouples mitotic events
The 1 reference without a DOI — listed, not checked
no DOI — not checkedXu, J. Preparation, culture, and immortalization of mouse embryonic fibroblasts. in Current Protocols in Molecular Biology (eds Frederick, M. A. et al.) Ch. 28, Unit 28.1 (2005).
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