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Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
43/43 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 43 checked references that resolve
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Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
resolves10.1038/ng1542
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease
resolves10.3389/fimmu.2016.00246
Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis
resolves10.1038/nm.4020
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
resolves10.1111/j.1477-2574.2009.00038.x
Incidence of individual organ dysfunction in fatal acute pancreatitis: analysis of 1024 death records
resolves10.1161/CIRCRESAHA.114.302113
Activation of NAD(P)H Oxidase by Tryptophan-Derived 3-Hydroxykynurenine Accelerates Endothelial Apoptosis and Dysfunction In Vivo
resolves10.1021/bi8010434
Kynurenine 3-Monooxygenase from <i>Pseudomonas fluorescens</i>: Substrate-like Inhibitors both Stimulate Flavin Reduction and Stabilize the Flavin−Peroxo Intermediate yet Result in the Production of Hydrogen Peroxide
resolves10.1016/j.expneurol.2016.05.005
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease
resolves10.1038/srep33951
Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis
resolves10.1177/1087057113518069
Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry
resolves10.1016/j.jmb.2009.06.008
Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan
resolves10.1074/jbc.M113.479303
Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation
resolves10.1046/j.1432-1327.2000.01104.x
Functional characterization and mechanism of action of recombinant human kynurenine 3‐hydroxylase
resolves10.1016/j.drudis.2015.11.001
Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors
resolves10.1016/j.bmcl.2017.02.078
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis
resolves10.1021/acs.jmedchem.7b00055
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
resolves10.1021/bi8002023
Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function
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Protein dynamics and electrostatics in the function of p-hydroxybenzoate hydroxylase
resolves10.1021/bi500655q
Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent <i>N</i>-Hydroxylase
resolves10.1021/bi051119t
Kinetics of Proton-Linked Flavin Conformational Changes in <i>p-</i>Hydroxybenzoate Hydroxylase
resolves10.3390/ijms131215601
Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases
resolves10.1021/bi301072w
Structural Insight into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases
resolves10.1107/S0907444910048675
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The 2 references without a DOI — listed, not checked
no DOI — not checkedWilkinson, M. Structural dynamics and ligand binding in kynurenine-3-monooxygenase. Doctoral thesis, University of Edinburgh (2013).
no DOI — not checkedBricogne, G. et al. BUSTER version 2.11.5 Global Phasing Ltd. (2014).
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