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Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling
70/70 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
The 70 checked references that resolve
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Regulation of Glucose Transporter Translocation in Health and Diabetes
resolves10.1016/j.tem.2010.12.001
Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis
resolves10.1074/jbc.M306782200
Isoform-specific Regulation of Insulin-dependent Glucose Uptake by Akt/Protein Kinase B
resolves10.1126/science.1096706
A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in
<i>AKT2</i>
resolves10.1126/science.292.5522.1728
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
resolves10.1172/JCI16885
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
resolves10.1074/jbc.C300063200
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation
resolves10.1074/jbc.M111.253880
Loss of AS160 Akt Substrate Causes Glut4 Protein to Accumulate in Compartments That Are Primed for Fusion in Basal Adipocytes
resolves10.1016/j.cmet.2011.06.015
C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane
resolves10.1016/j.cmet.2006.11.013
Dissecting Multiple Steps of GLUT4 Trafficking and Identifying the Sites of Insulin Action
resolves10.1016/j.cmet.2005.08.007
Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step
resolves10.2174/157339907780598199
&#x201C;Actin&#x201D;g on GLUT4: Membrane & Cytoskeletal Components of Insulin Action
resolves10.1172/JCI200112348
Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles
resolves10.1016/S0021-9258(18)43971-3
Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.
resolves10.1042/bj3310917
Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
resolves10.1091/mbc.e09-03-0187
Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerization
resolves10.1091/mbc.e12-04-0263
Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles
resolves10.1038/nature01246
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c
resolves10.1016/j.cmet.2008.09.011
CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes
resolves10.1507/endocrj.KR-65
Insulin Receptor Signals Regulating GLUT4 Translocation and Actin Dynamics
resolves10.1074/jbc.M108297200
Insulin-stimulated GLUT4 Translocation in Adipocytes Is Dependent upon Cortical Actin Remodeling
resolves10.1016/j.cmet.2008.02.008
Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes
resolves10.1074/jbc.271.49.31372
Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation
resolves10.1002/cm.21031
Tropomodulins: Pointed‐end capping proteins that regulate actin filament architecture in diverse cell types
resolves10.1006/geno.1999.6061
Sequencing, Expression Analysis, and Mapping of Three Unique Human Tropomodulin Genes and Their Mouse Orthologs
resolves10.1083/jcb.200209057
Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility
resolves10.1006/bbrc.2001.5620
Insulin-Regulated Trafficking of Dual-Labeled Glucose Transporter 4 in Primary Rat Adipose Cells
resolves10.1074/jbc.M110.144873
Mammalian Tropomodulins Nucleate Actin Polymerization via Their Actin Monomer Binding and Filament Pointed End-capping Activities*
resolves10.1083/jcb.201001125
Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology
resolves10.1016/S0006-3495(02)75281-8
Crystal Structure of the C-Terminal Half of Tropomodulin and Structural Basis of Actin Filament Pointed-End Capping
resolves10.1074/jbc.M110.186924
Identification of Residues within Tropomodulin-1 Responsible for Its Localization at the Pointed Ends of the Actin Filaments in Cardiac Myocytes
resolves10.1152/ajpcell.00107.2006
Loss of cortical actin filaments in insulin-resistant skeletal muscle cells impairs GLUT4 vesicle trafficking and glucose transport
resolves10.1242/jcs.113.2.279
Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes
resolves10.1007/s00125-011-2334-y
Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle
resolves10.1074/jbc.M108280200
A Phosphatidylinositol 3-Kinase-independent Insulin Signaling Pathway to N-WASP/Arp2/3/F-actin Required for GLUT4 Glucose Transporter Recycling
resolves10.1128/MCB.24.12.5447-5458.2004
Unconventional Myosin Myo1c Promotes Membrane Fusion in a Regulated Exocytic Pathway
resolves10.1091/mbc.e10-04-0316
Arp2/3- and Cofilin-coordinated Actin Dynamics Is Required for Insulin-mediated GLUT4 Translocation to the Surface of Muscle Cells
resolves10.1210/me.2003-0294
Skeletal Muscle Cells and Adipocytes Differ in Their Reliance on TC10 and Rac for Insulin-Induced Actin Remodeling
resolves10.1096/fj.09-137380
Crucial role of the small GTPase Rac1 in insulin‐stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma
resolves10.1074/jbc.M402697200
Disruption of Cortical Actin in Skeletal Muscle Demonstrates an Essential Role of the Cytoskeleton in Glucose Transporter 4 Translocation in Insulin-sensitive Tissues
resolves10.2337/db06-0823
Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells
resolves10.1016/S0960-9822(95)00256-9
The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes
resolves10.1055/s-0029-1211762
Changes in the signalling status of the small GTP-binding proteins Rac and Rho do not influence insulin-stimulated hexose transport
resolves10.1128/MCB.19.6.4008
Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts
resolves10.1016/j.cellsig.2013.02.023
Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells
resolves10.1111/febs.12719
A critical role of the small <scp>GTP</scp>ase Rac1 in Akt2‐mediated <scp>GLUT</scp>4 translocation in mouse skeletal muscle
resolves10.1016/j.cmet.2007.03.001
Rab10, a Target of the AS160 Rab GAP, Is Required for Insulin-Stimulated Translocation of GLUT4 to the Adipocyte Plasma Membrane
resolves10.1016/j.cmet.2005.09.005
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein
resolves10.1074/jbc.M114.555128
Differential Actin-regulatory Activities of Tropomodulin1 and Tropomodulin3 with Diverse Tropomyosin and Actin Isoforms
resolves10.1002/(SICI)1097-0169(1998)39:2<172::AID-CM8>3.0.CO;2-8
Actin depolymerizing factor and cofilin phosphorylation dynamics: Response to signals that regulate neurite extension
resolves10.1074/jbc.M312591200
Phosphoinositide 3-Kinase-mediated Activation of Cofilin Phosphatase Slingshot and Its Role for Insulin-induced Membrane Protrusion
resolves10.1182/blood-2010-02-268458
Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of Tropomodulin 3 in red blood cells and disruption of the membrane skeleton
resolves10.1091/mbc.e02-04-0244
Specification of Actin Filament Function and Molecular Composition by Tropomyosin Isoforms
resolves10.1016/j.yexcr.2010.10.019
Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments
resolves10.1083/jcb.200305031
The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes
resolves10.1016/j.tcb.2005.04.007
Tropomyosin isoforms: divining rods for actin cytoskeleton function
resolves10.1371/journal.pone.0077248
Regulation of Myosin Light Chain Kinase during Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes
resolves10.1042/BJ20121121
Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin
resolves10.1016/j.ab.2011.01.022
An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes
resolves10.1091/mbc.e06-07-0585
Insulin Signaling Diverges into Akt-dependent and -independent Signals to Regulate the Recruitment/Docking and the Fusion of GLUT4 Vesicles to the Plasma Membrane
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