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The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

https://doi.org/10.1038/ni.2171
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48/48 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 48 checked references that resolve
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Macrophage Signaling and Respiratory Burst
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Respiratory Burst: Role in Signal Transduction in Alveolar Macrophages
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The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels
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Phosphorylation of p47<i><sup>p</sup></i><i><sup>hox</sup></i>Sites by PKC α, βΙΙ, δ, and ζ:  Effect on Binding to p22<i><sup>p</sup></i><i><sup>hox</sup></i>and on NADPH Oxidase Activation
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Regulation of Superoxide Anion Production by NADPH Oxidase in Monocytes/Macrophages
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Molecular Cloning of a Novel Putative Ca2+Channel Protein (TRPC7) Highly Expressed in Brain
resolves10.1126/science.1062473
Immunocyte Ca <sup>2+</sup> Influx System Mediated by LTRPC2
resolves10.1146/annurev.physiol.68.040204.101406
PERMEATION AND SELECTIVITY OF TRP CHANNELS
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Role of TRPM2 Channel in Mediating H <sub>2</sub> O <sub>2</sub> -Induced Ca <sup>2+</sup> Entry and Endothelial Hyperpermeability
resolves10.1126/scisignal.2000278
TRPM2 Functions as a Lysosomal Ca<sup>2+</sup>-Release Channel in β Cells
resolves10.1038/nm1758
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
resolves10.1089/ars.2007.1785
Role of Oxidants in Lung Injury During Sepsis
resolves10.1165/rcmb.F278
Oxidative Stress and Acute Lung Injury
resolves10.1042/bj2370111
The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase
resolves10.1038/sj.bjp.0705914
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymerase
resolves10.1089/ars.2010.3137
Overexpression of Peroxiredoxin 4 Protects Against High-Dose Streptozotocin-Induced Diabetes by Suppressing Oxidative Stress and Cytokines in Transgenic Mice
resolves10.1152/ajpheart.00501.2009
Stress-induced senescence exaggerates postinjury neointimal formation in the old vasculature
resolves10.1016/j.bbabio.2006.01.005
Charge compensation during the phagocyte respiratory burst
resolves10.1016/j.bbamem.2007.05.011
The gramicidin ion channel: A model membrane protein
resolves10.1084/jem.20091837
VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification
resolves10.1152/physrev.00001.2002
TRP Channel Proteins and Signal Transduction
resolves10.1016/j.ceca.2005.06.028
TRP channels: An overview
resolves10.1007/s00232-005-0839-3
The Role of TRP Channels in Oxidative Stress-induced Cell Death
resolves10.1016/S1097-2765(01)00438-5
LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death
resolves10.1074/jbc.M112096200
Activation of the Cation Channel Long Transient Receptor Potential Channel 2 (LTRPC2) by Hydrogen Peroxide
resolves10.1016/0014-5793(89)80624-6
Biphasic increase in intracellular calcium induced by platelet‐activating factor in macrophages
resolves10.1002/jlb.64.6.817
Platelet-activating factor induces a concentration-dependent spectrum of functional responses in bovine neutrophils
resolves10.1038/ni1441
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4
resolves10.1074/jbc.M305127200
Voltage Dependence of the Ca2+-activated Cation Channel TRPM4
resolves10.1038/294752a0
Inward current channels activated by intracellular Ca in cultured cardiac cells
resolves10.1073/pnas.2334624100
TRPM5 is a transient Ca <sup>2+</sup> -activated cation channel responding to rapid changes in [Ca <sup>2+</sup> ] <sub>i</sub>
resolves10.1016/S0092-8674(02)00719-5
TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization
resolves10.1096/fj.10-178483
Dendritic cell maturation and chemotaxis is regulated by TRPM2‐mediated lysosomal Ca <sup>2+</sup> release
resolves10.1113/jphysiol.2010.201855
TRPM2: a multifunctional ion channel for calcium signalling
resolves10.1038/33725
Electron currents generated by the human phagocyte NADPH oxidase
resolves10.7326/0003-4819-93-3-480
Oxygen Metabolism and the Toxic Properties of Phagocytes
resolves10.1242/jcs.00627
Regulation of eosinophil membrane depolarization during NADPH oxidase activation
resolves10.1042/BJ20041889
Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase
resolves10.1113/jphysiol.2010.194225
Physiological roles of voltage-gated proton channels in leukocytes
resolves10.1016/j.cardiores.2006.07.011
Role of KATP channels in sepsis
resolves10.1097/shk.0b013e31812386bf
ENDOTOXIN IMPAIRS THE HUMAN PACEMAKER CURRENT I f
resolves10.1046/j.1523-1755.1998.00090.x
Selectivity of endotoxin-induced defect in endothelial calcium mobilization
resolves10.1073/pnas.1010678108
Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against <i>Listeria monocytogenes</i>
resolves10.1038/ni.1628
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins
resolves10.4049/jimmunol.177.7.4853
Caveolin-1 Regulates NF-κB Activation and Lung Inflammatory Response to Sepsis Induced by Lipopolysaccharide
resolves10.1074/jbc.M610248200
Blockade of Class IA Phosphoinositide 3-Kinase in Neutrophils Prevents NADPH Oxidase Activation- and Adhesion-dependent Inflammation
resolves10.1074/jbc.M105038200
Calcium-G Protein Interactions in the Regulation of Macrophage Secretion
The 3 references without a DOI — listed, not checked
no DOI — not checkedDeCoursey, T.E. Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. Physiology (Bethesda) 25, 27–40 (2010).
no DOI — not checkedSuto, M.J., Turner, W.R., Arundel-Suto, C.M., Werbel, L.M. & Sebolt-Leopold, J.S. Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase. Anticancer Drug Des. 6, 107–117 (1991).
no DOI — not checkedZhang, X., Goncalves, R. & Mosser, D.M. in Current Protocols in Immunology (eds. Coligan, J.E., Bierer, B.E., Margulies, D.H., Shevach, E.M. & Strober, W.) Ch 14, Unit 14 1 (John Wiley & Sons, Chichester, UK, 2008).
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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