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CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand
50/50 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
The 50 checked references that resolve
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B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands
resolves10.1016/j.immuni.2007.06.007
B Cells Acquire Particulate Antigen in a Macrophage-Rich Area at the Boundary between the Follicle and the Subcapsular Sinus of the Lymph Node
resolves10.1146/annurev.immunol.15.1.453
INITIATION AND PROCESSING OF SIGNALS FROM THE B CELL ANTIGEN RECEPTOR
resolves10.1016/S1074-7613(00)00003-0
Monomeric and Oligomeric Complexes of the B Cell Antigen Receptor
resolves10.1038/ni1262
The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer
resolves10.1146/annurev.immunol.18.1.393
Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex
resolves10.1126/science.1373518
CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes
resolves10.1016/1074-7613(95)90157-4
Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
resolves10.1038/376352a0
Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice
resolves10.1016/S1074-7613(00)80433-1
Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen
resolves10.4049/jimmunol.159.7.3278
Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19
resolves10.1016/S1074-7613(00)80094-1
Modulation of B Lymphocyte Antigen Receptor Signal Transduction by a CD19/CD22 Regulatory Loop
resolves10.4049/jimmunol.157.8.3404
Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG responses in vitro
resolves10.4049/jimmunol.161.3.1313
Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response
resolves10.1126/science.1125703
Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells
resolves10.1038/ni1494
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
resolves10.1126/science.1123940
B Cell Ligand Discrimination Through a Spreading and Contraction Response
resolves10.1016/S1074-7613(04)00105-0
LFA-1/ICAM-1 Interaction Lowers the Threshold of B Cell Activation by Facilitating B Cell Adhesion and Synapse Formation
resolves10.1038/sj.emboj.7600944
B‐cell activation by membrane‐bound antigens is facilitated by the interaction of VLA‐4 with VCAM‐1
resolves10.1126/science.285.5425.221
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
resolves10.1126/science.289.5483.1349
Differential Clustering of CD4 and CD3ζ During T Cell Recognition
resolves10.1083/jcb.120.1.25
Unconfined lateral diffusion and an estimate of pericellular matrix viscosity revealed by measuring the mobility of gold-tagged lipids.
resolves10.1016/j.cell.2005.04.009
Single-Molecule Microscopy Reveals Plasma Membrane Microdomains Created by Protein-Protein Networks that Exclude or Trap Signaling Molecules in T Cells
resolves10.1084/jem.20051182
Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling
resolves10.1038/ni1272
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
resolves10.1083/jcb.116.1.219
Divalent cation regulation of the function of the leukocyte integrin LFA-1.
resolves10.1016/S1074-7613(00)80580-4
Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate
resolves10.1073/pnas.91.2.474
The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment.
resolves10.1016/j.immuni.2006.04.010
T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster
resolves10.1084/jem.181.3.1005
The B cell antigen receptor of class IgD induces a stronger and more prolonged protein tyrosine phosphorylation than that of class IgM.
resolves10.1083/jcb.200203043
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
resolves10.1146/annurev.immunol.21.120601.141036
Molecular Interactions Mediating T Cell Antigen Recognition
resolves10.1038/nature03843
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
resolves10.1038/381325a0
Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
resolves10.1084/jem.170.6.2159
CD19 is functionally and physically associated with surface immunoglobulin.
resolves10.1128/MCB.21.24.8615-8625.2001
Visualization of Negative Signaling in B Cells by Quantitative Confocal Microscopy
resolves10.4049/jimmunol.158.7.3062
Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex
resolves10.1084/jem.184.5.1685
B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.
resolves10.1038/334676a0
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
resolves10.1073/pnas.73.10.3671
Molecular determinants of immunogenicity: the immunon model of immune response.
resolves10.1002/(SICI)1521-4141(199909)29:09<2923::AID-IMMU2923>3.0.CO;2-Y
Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice
resolves10.1073/pnas.93.8.3357
Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.
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